Preferential location of somatostatin receptors in germinal centers of human gut lymphoid tissue

Reubi, Jean Claude; Horisberger, Ursula; Waser, Bea; Gebbers, Jan‐Olaf; Laissue, Jean A.

doi:10.1016/0016-5085(92)91505-x

Cited by 94 publications

(44 citation statements)

References 43 publications

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“…In vitro differentiation of human peripheral blood B lymphocytes into plasma cells is shown to be reduced by octreotide, indicating the involvement of sst 2 and/or sst 5 . These findings correlate with the presence of binding sites for octreotide in the A c c e p t e d M a n u s c r i p t 8 germinal centres of secondary lymphoid follicles (Reubi et al, 1998;Reubi et al, 1992). These are sites of the generation of B memory cells and somatic hypermutation, a process to generate B cells with a high affinity B cell receptor.…”

Section: Effects Of Srif On the B Cell Lineagementioning

confidence: 80%

The role of cortistatin in the human immune system

Hagen

Dalm

Staal

et al. 2008

Molecular and Cellular Endocrinology

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Please cite this article as: van Hagen, P.M., Dalm, V.A., Staal, F., Hofland, L.J., The Role of Cortistatin in the Human Immune System, Molecular and Cellular Endocrinology (2007Endocrinology ( ), doi:10.1016Endocrinology ( /j.mce.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractCortistatin (CST) is a recently described neuropeptide that shares high homology with somatostatin (somatotropin release-inhibiting factor, SRIF) and binds with high affinity to all somatostatin receptor (sst) subtypes. CST is currently known to have a widespread distribution in many human organs including the immune system. The activities specific to CST may be partially attributable to its binding to the growth hormone secretagogue (GHS) receptor (GHS-R) and the orphan Gprotein-coupled receptor MrgX2. Human immune cells produce CST, whereas macrophage lineage and activated endothelium express sst 2 , and human lymphocytes express sst 3 . The human thymus expresses sst 1,2,3 , MrgX2 and almost all immune cells express GHS-R. Moreover, at this very moment promising research with CST in experimental animal models is being performed. On the basis of these promising results, studies aiming to further evaluate the possibilities of CST as a therapeutic agent in human immune mediated inflammatory diseases are warranted.

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Section: Effects Of Srif On the B Cell Lineagementioning

confidence: 80%

The role of cortistatin in the human immune system

Hagen

Dalm

Staal

et al. 2008

Molecular and Cellular Endocrinology

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“…Work by Reubi et al (21,22) demonstrated the presence of ssts in normal human lymphoid tissues, including gut-associated lymphoid tissue, thymus, spleen and lymph nodes. Moreover, in addition to ssts, several other peptide receptors, were localized in distinct compartments of the immune tissues (22,23).…”

Section: Somatostatin Binding Sites On Human Immune Cellsmentioning

confidence: 99%

“…Moreover, in addition to ssts, several other peptide receptors, were localized in distinct compartments of the immune tissues (22,23). SSTs were localized mainly in the germinal centres of lymphoid follicles, and more diffusely in the red pulp of the spleen and in the medulla of the thymus.…”

Section: Somatostatin Binding Sites On Human Immune Cellsmentioning

confidence: 99%

Somatostatin receptor subtypes in human immune cells

Lichtenauer-Kaligis¹,

Hagen

Lamberts³

et al. 2000

European Journal of Endocrinology

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“…Binding assays and autoradiographic studies have shown the presence of hsst in normal and tumoural colon mucosa, nerve plexus, lymphoid tissue and the peritumoural veins (Iftikhar et al 1992, Radulovic et al 1992, Reubi et al 1992, 1994. Few recent studies have analysed the expression of the different hsst subtypes in colonic tissue, giving controversial results.…”

Section: Introductionmentioning

confidence: 99%

Increased expression of the mRNA encoding the somatostatin receptor subtype five in human colorectal adenocarcinoma

Vuaroqueaux¹,

Dutour²,

Bourhim³

et al. 2000

Journal of Molecular Endocrinology

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Numerous studies have suggested that the antiproliferative potency of somatostatin (SS) analogues may be an efficient tool to improve the prognosis of colorectal cancer. In order to facilitate current efforts to design potent antitumour SS analogues, we studied the distribution of human SS receptors (hsst1-5) mRNAs in a large set of tumoural and normal colonic tissues. Localisation of hsst1-5 mRNAs in normal and tumoural tissues was performed by in situ hybridisation using radioactive antisense or sense riboprobes. Semi-quantitative analysis of hsst5 mRNA was performed using a computerised image analysis system. Hsst binding sites were characterised by studying the relative potency of SS14, SS28 or SS analogues in displacing -SS14 (IC 50 =15 and 157 nM respectively), while BIM23197 (an analogue that shows preferential affinity for hsst2) was ineffective. Our results show a high expression of hsst5 mRNA in human tumoural colonic tissue, while hsst5 protein is the predominant hsst protein subtype in a tumoural colonic cell line.

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Preferential location of somatostatin receptors in germinal centers of human gut lymphoid tissue

Cited by 94 publications

References 43 publications

The role of cortistatin in the human immune system

The role of cortistatin in the human immune system

Somatostatin receptor subtypes in human immune cells

Increased expression of the mRNA encoding the somatostatin receptor subtype five in human colorectal adenocarcinoma

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