Preferential Migration of T Regulatory Cells Induced by IL-16

McFadden, Caroline; Morgan, Ross; Rahangdale, Shilpa; Green, Daniel; Yamasaki, Hidemasa; Center, David M.; Cruikshank, William W.

doi:10.4049/jimmunol.179.10.6439

Cited by 94 publications

(79 citation statements)

References 45 publications

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“…A combination of IL-17D with EBI3 results in formation of either IL-27, which is associated with negative regulation of Th17 differentiation [38], or of IL-35, an inhibitory cytokine associated with suppressive functions of regulatory T cells [39]. We detected elevated transcription of genes encoding IL-15, associated with IL-2 responsiveness and survival of NK cells [40] and expression of Foxp3 in CD4 1 T cells [41], and IL-16, linked to recruitment of CD4 1 T cells, in particular regulatory T cells [42] in H37Ra-infected iNOS -/-mice at later time points during infection.…”

Section: Adaptive Immune Responsementioning

confidence: 81%

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Beisiegel¹,

Mollenkopf²,

Hahnke³

et al. 2009

Eur J Immunol

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Progression and outcome of tuberculosis is governed by extensive crosstalk between pathogen and host. Analyses of global changes in gene expression during immune response to infection with Mycobacterium tuberculosis (M.tb) can help identify molecular markers of disease state and progression. Global distribution of M.tb strains with different degrees of virulence and drug resistance, especially for the immunocompromised host, make closer analyses of host responses more pressing than ever. Here, we describe global transcriptional responses of inducible nitric oxide synthase-deficient (iNOS -/-) and WT mice infected with two related M.tb strains of markedly different virulence, namely the M.tb laboratory strains H37Rv and H37Ra. Both hosts exhibited highly similar resistance to infection with H37Ra. In contrast, iNOS -/-mice rapidly succumbed to H37Rv, whereas WT mice developed chronic course of disease. By differential analyses, virulence-specific changes in global host gene expression were analyzed to identify molecular markers characteristic for chronic versus acute infection. We identified several markers unique for different stages of disease progression and not previously associated with virulencespecific host responses in tuberculosis.

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Section: Adaptive Immune Responsementioning

confidence: 81%

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Beisiegel¹,

Mollenkopf²,

Hahnke³

et al. 2009

Eur J Immunol

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“…IL-1β or TNF-α expression can lead to increased IL-16 expression by epithelial cells (Little et al, 2003) a cytokine with an immunomodulatory role in asthmatic inflammation (De Bie et al, 2002;McFadden et al, 2007). IL-1Ra is an antagonist to IL-1α/β signaling in the lung (Wilmott et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Moringa Tea Blocks Acute Lung Inflammation Induced by Swine Confinement Dust Through a Mechanism Involving TNF-Î± Expression, C-Jun N-Terminal Kinase Activation and Neutrophil Regulation

McKnight¹

2014

American Journal of Immunology

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Plant based products represent a promising alternative to conventional treatments for inflammation. Moringa oleifera Lam is a tree rich in proteins, vitamins, minerals and a variety of phytochemcals with health benefits. Among the reported health benefits are antioxidant and anti-inflammatory properties. The purpose of this study was to investigate whether tea brewed from dried Moringa leaves would abrogate inflammation in a mouse model of acute lung inflammation induced by LPS or extracts prepared from dust collected from a swine confinement facility (DE). Mice were offered water or Moringa tea for seven days. Tea consumption was significantly greater than that of water consumption on days 1 and 6, but there were no significant differences in weight gain or food consumption. On day seven, mice from both groups were forced to inhale, via intranasal challenge, either Phosphate Buffered Saline (PBS), Lipopolysaccharide (LPS) [10 µg mLCompared to mice that drank water, mice that drank Moringa tea had significantly less protein (p<0.05) and cellular influx (p<0.0001) into the lung after inhalation of 10% DE. No difference in neutrophil migration into the lungs of water and M. tea groups after LPS or DE challenge was detected. But mice that drank tea had significantly (p<0.05) more neutrophils with apoptotic morphology after DE challenge. TNF-α expression 24 h after inhalation of 10% DE, was significantly higher (p<0.05) in lungs of M. tea mouse group as compared to water group. This increase in TNF-α was accompanied by higher levels of pro and anti-inflammatory cytokines. Finally, activation of c-Jun N-terminal Kinase (JNK) in lungs of M. tea+DE group 24 h post inhalation was decreased. Taken together these results suggest that Moringa oleifera leaf tea exerts antiinflammatory properties on acute lung inflammation induced by swine confinement dust through a mechanism involving neutrophil regulation and JNK activation.

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“…One hypothesis is that Treg cells are generated in the periphery and are selectively recruited from the periphery to the tumour. Recent studies have shown that certain cytokines and chemokines can selectively induce Treg cell migration over other T cell populations [20,21]. The expression of specific integrins (ie.…”

Section: Recruitment Of Treg Cells To Mesotheliomasmentioning

confidence: 99%

The Role of Regulatory T Cells in Mesothelioma

Ireland

Beilharz

2012

Cancer Microenvironment

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Malignant mesothelioma (MM) appears to be responsive to immunotherapy. The lack of complete tumour cure as a result of many immunotherapies tested to date suggests that the immune response to MM is complex and multi-parametric. Regulatory T (Treg) cells are prevalent within murine and human mesotheliomas with their removal shown to result in tumour growth inhibition and the release of anti-tumour effector T cells from immunosuppression. The targeting of immune checkpoints as treatments for various solid tumours has recently shown promise in clinical settings. In addition, synergy between chemotherapy and immunotherapy has been demonstrated for many cancers, including mesothelioma. Here we demonstrate Treg cells as critical mediators of the anti-tumour immune response to MM and potential targets for anti-tumour immunotherapy; though the timing and dosage of Treg cell manipulating immunotherapies need to be optimised.

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Preferential Migration of T Regulatory Cells Induced by IL-16

Cited by 94 publications

References 45 publications

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Moringa Tea Blocks Acute Lung Inflammation Induced by Swine Confinement Dust Through a Mechanism Involving TNF-Î± Expression, C-Jun N-Terminal Kinase Activation and Neutrophil Regulation

The Role of Regulatory T Cells in Mesothelioma

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