Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells

Essen, Mieke F van; Peereboom, Emma T. M.; Schlagwein, Nicole; Gijlswijk‐Janssen, Daniëlle J. van; Nelemans, Tessa; Joeloemsingh, Jivan V.; Berg, Cathelijne W. van den; Prins, Jurriën; Clark, Simon J.; Schmidt, Christoph Q.; Trouw, Leendert A.; Kooten, Cees van

doi:10.1016/j.imbio.2023.152364

Immunobiology

2023

DOI: 10.1016/j.imbio.2023.152364

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Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells

Mieke F van Essen

Emma T. M. Peereboom

Nicole Schlagwein

et al.

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Complement System and Adhesion Molecule Skirmishes in Fabry Disease: Insights into Pathogenesis and Disease Mechanisms

Magnusen,

Pandey

2024

IJMS

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Fabry disease is a rare X-linked lysosomal storage disorder caused by mutations in the galactosidase alpha (GLA) gene, resulting in the accumulation of globotriaosylceramide (Gb3) and its deacetylated form, globotriaosylsphingosine (Lyso-Gb3) in various tissues and fluids throughout the body. This pathological accumulation triggers a cascade of processes involving immune dysregulation and complement system activation. Elevated levels of complement 3a (C3a), C5a, and their precursor C3 are observed in the plasma, serum, and tissues of patients with Fabry disease, correlating with significant endothelial cell abnormalities and vascular dysfunction. This review elucidates how the complement system, particularly through the activation of C3a and C5a, exacerbates disease pathology. The activation of these pathways leads to the upregulation of adhesion molecules, including vascular cell adhesion molecule 1 (VCAM1), intercellular adhesion molecule 1 (ICAM1), platelet and endothelial cell adhesion molecule 1 (PECAM1), and complement receptor 3 (CR3) on leukocytes and endothelial cells. This upregulation promotes the excessive recruitment of leukocytes, which in turn exacerbates disease pathology. Targeting complement components C3a, C5a, or their respective receptors, C3aR (C3a receptor) and C5aR1 (C5a receptor 1), could potentially reduce inflammation, mitigate tissue damage, and improve clinical outcomes for individuals with Fabry disease.

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Complement System and Adhesion Molecule Skirmishes in Fabry Disease: Insights into Pathogenesis and Disease Mechanisms

Magnusen,

Pandey

2024

IJMS

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Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells

Cited by 1 publication

References 43 publications

Complement System and Adhesion Molecule Skirmishes in Fabry Disease: Insights into Pathogenesis and Disease Mechanisms

Complement System and Adhesion Molecule Skirmishes in Fabry Disease: Insights into Pathogenesis and Disease Mechanisms

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