Prefilled syringes versus vials: Impact on vaccination efficiency and patient safety in Indian private market

Kasi, SG; Prabhu, S.; Sanjay, S.; Chitkara, A. J.; Mitra, Monjori

doi:10.1016/j.pid.2013.11.005

Cited by 7 publications

(7 citation statements)

References 5 publications

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“…The single dose presentation should reduce vaccine wastage associated with multi-dose vials. Lastly, similar to previous studies [ 20 ] we found that simulated CPAD use reduced the average time per injection. However, the usefulness of a reduction in average injection time of 17 seconds is not clear, since injection time represents a small fraction of the total time required to vaccinate a child.…”

Section: Discussionsupporting

confidence: 91%

Acceptability and Feasibility of Delivering Pentavalent Vaccines in a Compact, Prefilled, Autodisable Device in Vietnam and Senegal

et al. 2015

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BackgroundPrefilled syringes are the standard in developed countries but logistic and financial barriers prevent their widespread use in developing countries. The current study evaluated use of a compact, prefilled, autodisable device (CPAD) to deliver pentavalent vaccine by field actors in Senegal and Vietnam.MethodsWe conducted a logistic, programmatic, and anthropological study that included a) interviews of immunization staff at different health system levels and parents attending immunization sessions; b) observation of immunization sessions including CPAD use on oranges; and c) document review.ResultsRespondents perceived that the CPAD would improve safety by being non-reusable and preventing needle and vaccine exposure during preparation. Preparation was considered simple and may reduce immunization time for staff and caretakers. CPAD impact on cold storage requirements depended on the current pentavalent vaccine being used; in both countries, CPAD would reduce the weight and volume of materials and safety boxes thereby potentially improving outreach strategies and waste disposal. CPAD also would reduce stock outages by bundling vaccine and syringes and reduce wastage by using a non-breakable plastic presentation. Respondents also cited potential challenges including ability to distinguish between CPAD and other pharmaceuticals delivered via a similar mechanism (such as contraceptives), safety, and concerns related to design and ease of administration (such as activation, ease of delivery, and needle diameter and length).ConclusionsCompared to current pentavalent vaccine presentations in Vietnam and Senegal, CPAD technology will address some of the main barriers to vaccination, such as supply chain issues and safety concerns among health workers and families. Most of the challenges we identified can be addressed with health worker training, minor design modifications, and health messaging targeting parents and communities. Potentially the largest remaining barrier is the marginal increase in pentavalent cost – if any – from CPAD use, which we did not assess in our study.

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Section: Discussionsupporting

confidence: 91%

Acceptability and Feasibility of Delivering Pentavalent Vaccines in a Compact, Prefilled, Autodisable Device in Vietnam and Senegal

et al. 2015

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“…Efforts to increase card retention would be useful and some strategies have been successful [68]; alternatively, new technologies such as rapid detection of biomarkers may identify children in need of vaccination [69,70]. Prefilled syringes or single-dose vials can overcome reluctance to open multi-dose vials [71]. Social messaging and provider training may address perceived contraindications.…”

Section: Discussionmentioning

confidence: 99%

A systematic literature review of missed opportunities for immunization in low- and middle-income countries

Sridhar¹,

Maleq²,

Guillermet³

et al. 2014

Vaccine

112

105

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“…Due to the all-in-one design of the cPAD, fewer manipulations are required than single-or multi-dose vials (Figure 1). This reduces administration time 26,27 while potentially reducing handling errors 28 and increasing accurate dose administration 29 . Importantly, the AD format reduces the likelihood of cross-contamination and missed vaccination opportunities 26 .…”

Section: Innovative Approaches Could Have a Significant Impact On The Future Of Immunization Programs In Developing Countriesmentioning

confidence: 99%

Reaching more children with vaccines in developing countries: key challenges of innovation and delivery

Popova

2015

Current Medical Research and Opinion

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As we reach the deadline for the United Nations fourth Millennium Development Goal to reduce child mortality, many inequalities in vaccine access still exist, particularly for children in developing countries. Here we discuss some of the barriers to vaccine access in these countries, as well as some of the innovative approaches that could address these. Finally, we discuss the need to create a global environment conducive to innovation directed at low-resource settings, aimed to ultimately increase vaccine coverage.

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Prefilled syringes versus vials: Impact on vaccination efficiency and patient safety in Indian private market

Cited by 7 publications

References 5 publications

Acceptability and Feasibility of Delivering Pentavalent Vaccines in a Compact, Prefilled, Autodisable Device in Vietnam and Senegal

Acceptability and Feasibility of Delivering Pentavalent Vaccines in a Compact, Prefilled, Autodisable Device in Vietnam and Senegal

A systematic literature review of missed opportunities for immunization in low- and middle-income countries

Reaching more children with vaccines in developing countries: key challenges of innovation and delivery

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