Preformulation Challenges: The Concept Behind the Selection, Design and Preparation of Nanoformulations

Patel, Krishna Kumar; Agrawal, Ashish Kumar; Singh, Sanjay

doi:10.1007/978-3-030-41858-8_3

Cited by 4 publications

(1 citation statement)

References 120 publications

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“…Nanoparticles are carriers with dimensions ranging from 1 to 1000 nm [ 214 ]. They are equipped with exclusive attributes that include enhanced bioavailability, improved internalization into the tumor site, site-specific delivery, anti-metastatic activity, and evading multi-drug resistance (MDR) [ 212 , 215 , 216 ]. The various nanotechnology-based drug delivery system developed for the treatment of TNBC includes liposomes, dendrimers, polymeric micelles, polymeric nanoparticles, carbon nanotubes, metallic nanoparticles, nanoemulsions, solid lipid nanoparticles (SLN), and nanostructured lipid carriers (NLC) ( Figure 5 ).…”

Section: Nanotechnology: Cavalry For Tnbc Therapymentioning

confidence: 99%

Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)

et al. 2022

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Triple-negative breast cancer (TNBC) is considered one of the un-manageable types of breast cancer, involving devoid of estrogen, progesterone, and human epidermal growth factor receptor 2 (HER 2) receptors. Due to their ability of recurrence and metastasis, the management of TNBC remains a mainstay challenge, despite the advancements in cancer therapies. Conventional chemotherapy remains the only treatment regimen against TNBC and suffers several limitations such as low bioavailability, systemic toxicity, less targetability, and multi-drug resistance. Although various targeted therapies have been introduced to manage the hardship of TNBC, they still experience certain limitations associated with the survival benefits. The current research thus aimed at developing and improving the strategies for effective therapy against TNBC. Such strategies involved the emergence of nanoparticles. Nanoparticles are designated as nanocavalries, loaded with various agents (drugs, genes, etc.) to battle the progression and metastasis of TNBC along with overcoming the limitations experienced by conventional chemotherapy and targeted therapy. This article documents the treatment regimens of TNBC along with their efficacy towards different subtypes of TNBC, and the various nanotechnologies employed to increase the therapeutic outcome of FDA-approved drug regimens.

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Section: Nanotechnology: Cavalry For Tnbc Therapymentioning

confidence: 99%

Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)

et al. 2022

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Role of polyphenolic compounds and their nanoformulations: a comprehensive review on cross-talk between chronic kidney and cardiovascular diseases

Rajput

Sharma

Singh

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Therapeutic potential of venom peptides: insights in the nanoparticle-mediated venom formulations

et al. 2022

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Background Venoms are the secretions produced by animals, generally for the purpose of self-defense or catching a prey. Biochemically venoms are mainly composed of proteins, lipids, carbohydrates, ions, etc., and classified into three major classes, viz. neurotoxic, hemotoxic and cytotoxic based upon their mode of action. Venoms are composed of different specific peptides/toxins which are responsible for their unique biological actions. Though venoms are generally seen as a source of death, scientifically venom is a complex biochemical substance having a specific pharmacologic action which can be used as agents to diagnose and cure a variety of diseases in humans. Main body Many of these venoms have been used since centuries, and their specified therapies can also be found in ancient texts such as Charka Samhita. The modern-day example of such venom therapeutic is captopril, an antihypertensive drug developed from venom of Bothrops jararaca. Nanotechnology is a modern-day science of building materials on a nanoscale with advantages like target specificity, increased therapeutic response and diminished side effects. In the present review we have introduced the venom, sources and related constituents in brief, by highlighting the therapeutic potential of venom peptides and focusing more on the nanoformulations-based approaches. This review is an effort to compile all such report to have an idea about the future direction about the nanoplatforms which should be focused to have more clinically relevant formulations for difficult to treat diseases. Conclusion Venom peptides which are fatal in nature if used cautiously and effectively can save life. Several research findings suggested that many of the fatal diseases can be effectively treated with venom peptides. Nanotechnology has emerged as novel strategy in diagnosis, treatment and mitigation of diseases in more effective ways. A variety of nanoformulation approaches have been explored to enhance the therapeutic efficacy and reduce the toxicity and targeted delivery of the venom peptide conjugated with it. We concluded that venom peptides along with nanoparticles can evolve as the new era for potential treatments of ongoing and untreatable diseases. Graphical Abstract

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Preformulation Challenges: The Concept Behind the Selection, Design and Preparation of Nanoformulations

Cited by 4 publications

References 120 publications

Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)

Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)

Role of polyphenolic compounds and their nanoformulations: a comprehensive review on cross-talk between chronic kidney and cardiovascular diseases

Therapeutic potential of venom peptides: insights in the nanoparticle-mediated venom formulations

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