Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis

McKenzie, Barbara; Kay, Graeme; Matthews, Kerr H.; Knott, Rachel M.; Cairns, Donald

doi:10.1016/j.ijpharm.2016.10.044

Cited by 21 publications

(25 citation statements)

References 43 publications

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“… 49 Furthermore, BAC reduced the surface tension, allowing the gel more dispersive power on the ocular surface. 51 Moreover, alpha-cyclodextrin allowed 20 times greater penetrance of cysteamine at a concentration of 5.5%. 49 The time to identification of cysteamine in the receptor compartment still remained at 1 hour.…”

Section: Introduction To Epidemiology Etiology and Pathophysiology mentioning

confidence: 99%

“… 51 However, only sodium hyaluronate (0.3%) showed long-term stability and was greatest when dispensed in ampoules. 51 …”

Section: Introduction To Epidemiology Etiology and Pathophysiology mentioning

confidence: 99%

“… 54 A study from 2016 considered hydrogel formulations for cysteamine hydrochloride 0.55% and BAC as a preservative. 51 Hydrogels can be pseudoplastic, transparent, and bioadhesive, thereby permitting prolonged drug release and, thus, optimizing bioavailability and compliance through less frequent drug administration. 51 Carbomer 974 (0.25%) and xanthan (0.3%) gels were proven to be of poor stability.…”

Section: Introduction To Epidemiology Etiology and Pathophysiology mentioning

confidence: 99%

“… 51 Hydrogels can be pseudoplastic, transparent, and bioadhesive, thereby permitting prolonged drug release and, thus, optimizing bioavailability and compliance through less frequent drug administration. 51 Carbomer 974 (0.25%) and xanthan (0.3%) gels were proven to be of poor stability. 51 In contrast, sodium hyaluronate (0.3%), carbomer 934 (0.3%), and hydroxyethyl cellulose (0.8%) dispensed cysteamine over 45–50 minutes.…”

Section: Introduction To Epidemiology Etiology and Pathophysiology mentioning

confidence: 99%

“… 51 Carbomer 974 (0.25%) and xanthan (0.3%) gels were proven to be of poor stability. 51 In contrast, sodium hyaluronate (0.3%), carbomer 934 (0.3%), and hydroxyethyl cellulose (0.8%) dispensed cysteamine over 45–50 minutes. 51 However, only sodium hyaluronate (0.3%) showed long-term stability and was greatest when dispensed in ampoules.…”

Section: Introduction To Epidemiology Etiology and Pathophysiology mentioning

confidence: 99%

See 4 more Smart Citations

Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

Makuloluwa

Shams

2018

OPTH

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Section: Introduction To Epidemiology Etiology and Pathophysiology mentioning

confidence: 99%

“… 51 However, only sodium hyaluronate (0.3%) showed long-term stability and was greatest when dispensed in ampoules. 51 …”

Section: Introduction To Epidemiology Etiology and Pathophysiology mentioning

confidence: 99%

Section: Introduction To Epidemiology Etiology and Pathophysiology mentioning

confidence: 99%

Section: Introduction To Epidemiology Etiology and Pathophysiology mentioning

confidence: 99%

Section: Introduction To Epidemiology Etiology and Pathophysiology mentioning

confidence: 99%

See 3 more Smart Citations

Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

Makuloluwa

Shams

2018

OPTH

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Application of Thermogels to the Anterior of the Eye as Alternatives to Conventional Eyedrops

Ross

Sheardown

2023

Advanced Therapeutics

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The anterior of the eye can be affected by numerous different diseases, but the treatment of these diseases is dominated by topical formulations which are well documented to be largely ineffective. To increase the efficacy of these drugs, thermogel formulations have been developed for sustained release following application to the anterior of the eye. These thermogel formulations have been designed for either injectable or topical application. The types of polymers used to create the thermogels, testing methods, and subsequent performance will be outlined in this review. The current trends in design including increasing mechanical performance, utilizing designed degradation, incorporation of micro or nanoparticles, and developing mucoadhesion formulations are also highlighted.

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Development and Evaluation of a Diclofenac‐Loaded Thermogel for Topical Treatment of Corneal Alkali Burns

Ge,

Zhao,

Guo

et al. 2024

Macro Materials & Eng

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Corneal alkali burns have become a frequent and urgent issue in ophthalmology, but current treatments are limited. To address this, a diclofenac‐loaded thermogel with anti‐inflammatory agents is developed to target inflammation and improve drug delivery for corneal alkali burns. Thermogels are prepared by dissolving methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC) in phosphate‐buffered saline (PBS), adding diclofenac (DF), and storing the solution at 4 °C. The thermogel's temperature‐sensitive behavior and injectability at 35 °C are assessed. Freeze‐dried thermogels are examined using scanning electron microscopy. Rheological properties, swelling behavior, and in vitro release studies are conducted. In vitro and in vivo biocompatibility tests are performed. A corneal alkali burn model is established in rats, and different treatments are administered for 7 days. Eyeballs are collected for histological and molecular analysis. The thermogel formulation formed a stable gel at 35 °C and continuously released DF for 7 days. In vitro and in vivo tests confirmed the thermogels' excellent biocompatibility. The released DF promotes the expression of the anti‐inflammatory cytokine interleukin‐10 (IL‐10) and inhibits the expression of pro‐inflammatory factors TNF‐α and vascular endothelial growth factor (VEGF). This novel DF/thermogel offers an efficient, topical, and cost‐effective approach with significant potential for treating corneal alkali burns.

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Preformulation of cysteamine gels for treatment of the ophthalmic complications in cystinosis

Cited by 21 publications

References 43 publications

Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

Application of Thermogels to the Anterior of the Eye as Alternatives to Conventional Eyedrops

Development and Evaluation of a Diclofenac‐Loaded Thermogel for Topical Treatment of Corneal Alkali Burns

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