Prefrontal and parietal contributions to spatial working memory

Curtis, Clayton E.

doi:10.1016/j.neuroscience.2005.04.070

Cited by 264 publications

(208 citation statements)

References 83 publications

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“…The localization of the group differences in activation in the medial frontal cortex and precuneus is consistent with data from previous neuroimaging studies of SWM in schizophrenia (Gould et al 2003 ;Curtis, 2006). A different pattern of activation across groups was evident during the least demanding (' easy ') version of the task.…”

Section: Group Differences In Activationsupporting

confidence: 88%

Neural correlates of visuospatial working memory in the ‘at-risk mental state’

et al. 2010

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Background. Impaired spatial working memory (SWM) is a robust feature of schizophrenia and has been linked to the risk of developing psychosis in people with an at-risk mental state (ARMS). We used functional magnetic resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had just developed schizophrenia.Method. fMRI was used to study 17 patients with an ARMS, 10 patients with a first episode of psychosis and 15 agematched healthy comparison subjects. The blood oxygen level-dependent (BOLD) response was measured while subjects performed an object-location paired-associate memory task, with experimental manipulation of mnemonic load.Results. In all groups, increasing mnemonic load was associated with activation in the medial frontal and medial posterior parietal cortex. Significant between-group differences in activation were evident in a cluster spanning the medial frontal cortex and right precuneus, with the ARMS groups showing less activation than controls but greater activation than first-episode psychosis (FEP) patients. These group differences were more evident at the most demanding levels of the task than at the easy level. In all groups, task performance improved with repetition of the conditions. However, there was a significant group difference in the response of the right precuneus across repeated trials, with an attenuation of activation in controls but increased activation in FEP and little change in the ARMS. Conclusions.Abnormal neural activity in the medial frontal cortex and posterior parietal cortex during an SWM task may be a neural correlate of increased vulnerability to psychosis.

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Section: Group Differences In Activationsupporting

confidence: 88%

Neural correlates of visuospatial working memory in the ‘at-risk mental state’

et al. 2010

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“…Consistent with this idea of retrieval, Silk et al (2010) have suggested that the motor planning map retained by neural activity in the right SMG is used as a basis for the control of attentional shifts. This highlights the close association that has been found to exist between the mechanisms of memory and attention in the PPC proposed by many studies (Jonides, Smith, Koeppe, Awh, Minoshima & Mintun, 1993;Smith & Jonides, 1997;Courtney, Ungerleider, Keil & Haxby, 1997;Vandenburgh et al, 1996;Nobre et al, 1997;Ungerleider, Courtney & Haxby, 1998;Kessels, d'Alfonso, Postma & de Haan, 2000;Corbetta et al, 2000;Hussain et al, 2001;Rizzolatti & Matelli, 2003: Koch, Oliveri, Torriero, Carlesimo, Turriziani & Caltagirone, 2005Curtis, 2006;Van Asselen, Kesseks, Neggers, Kapelle, Frijns & Postma, 2006;Berryhill & Olson, 2008a,b;Olson & Berryhill, 2009;Cabeza, Ciaramelli & Moscovitch, 2012;Corbetta & Shulman, 2002;Singh-Curry & Husain, 2009). One view is that attention and memory rely upon overlapping cortical networks sharing common neural resources within the PPC (Awh, Jonides & Reuter-Lorenz, 1998;Awh, Vogel & Oh, 2006;Postle Awh, Jonides, Smith & D'Esposito, 2004;Theeuwes, Belopolsky & Olivers, 2009).…”

Section: Dorso-parietal Versus Ventro-parietal Processing Pathwayssupporting

confidence: 55%

The contribution of the right supra-marginal gyrus to sequence learning in eye movements

et al. 2013

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We investigated the role of the human right Supra-Marginal Gyrus (SMG) in the generation of learned eye movement sequences. Using MRI-guided transcranial magnetic stimulation (TMS) we disrupted neural activity in the SMG whilst human observers performed saccadic eye movements to multiple presentations of either predictable or random target sequences. For the predictable sequences we observed shorter saccadic latencies from the second presentation of the sequence. However, these anticipatory improvements in performance were significantly reduced when TMS was delivered to the right SMG during the inter-trial retention periods. No deficits were induced when TMS was delivered concurrently with the onset of the target visual stimuli. For the random version of the task, neither delivery of TMS to the SMG during the inter-trial period nor during the presentation of the target visual stimuli produced any deficit in performance that was significantly different from the no-TMS or control conditions. These findings demonstrate that neural activity within the right SMG is causally linked to the ability to perform short latency predictive saccades resulting from sequence learning. We conclude that neural activity in rSMG constitutes an instruction set with spatial and temporal directives that are retained and subsequently released for predictive motor planning and responses.3

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“…However, in the present study, no brain regions (within or outside of the MTL) exhibited suprathreshold delay period activation in the accuracy contrast. This could not be attributed to an absence of delay period activity, however, because when the data from correct and incorrect trials were collapsed, persistent activity during the delay period was evident in a network of brain regions (e.g., bilateral frontal eye fields and posterior parietal cortex, along with supplementary eye fields and left dorsolateral prefrontal cortex) that are typically implicated in spatial short-term memory tasks (Curtis, 2006). These results are reported in the supplemental Results section (supplemental Fig.…”

Section: Prefrontal and Posterior Parietal Activationsmentioning

confidence: 96%

“…One possibility is that the relative absence of hippocampal activity in these experiments reflects use of strategies that obviate relational memory processing demands. For instance, participants may have retained object-location bindings in viewer-centered coordinates, a process that may be more dependent on prefrontal and posterior parietal cortices (Constantinidis and Wang, 2004;Curtis, 2006) than MTL structures.…”

Section: Introductionmentioning

confidence: 99%

Medial Temporal Lobe Activity Predicts Successful Relational Memory Binding

Hannula¹,

Ranganath²

2008

J. Neurosci.

260

205

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Previous neuropsychological findings have implicated medial temporal lobe (MTL) structures in retaining object-location relations over the course of short delays, but MTL effects have not always been reported in neuroimaging investigations with similar short-term memory requirements. Here, we used event-related functional magnetic resonance imaging to test the hypothesis that the hippocampus and related MTL structures support accurate retention of relational memory representations, even across short delays. On every trial, four objects were presented, each in one of nine possible locations of a three-dimensional grid. Participants were to mentally rotate the grid and then maintain the rotated representation in anticipation of a test stimulus: a rendering of the grid, rotated 90°from the original viewpoint. The test stimulus was either a "match" display, in which object-location relations were intact, or a "mismatch" display, in which one object occupied a new, previously unfilled location (mismatch position), or two objects had swapped locations (mismatch swap). Encoding phase activation in anterior and posterior regions of the left hippocampus, and in bilateral perirhinal cortex, predicted subsequent accuracy on the short-term memory decision, as did bilateral posterior hippocampal activity after the test stimulus. Notably, activation in these posterior hippocampal regions was also sensitive to the degree to which object-location bindings were preserved in the test stimulus; activation was greatest for match displays, followed by mismatch-position displays, and finally mismatch-swap displays. These results indicate that the hippocampus and related MTL structures contribute to successful encoding and retrieval of relational information in visual short-term memory.

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Prefrontal and parietal contributions to spatial working memory

Cited by 264 publications

References 83 publications

Neural correlates of visuospatial working memory in the ‘at-risk mental state’

Neural correlates of visuospatial working memory in the ‘at-risk mental state’

The contribution of the right supra-marginal gyrus to sequence learning in eye movements

Medial Temporal Lobe Activity Predicts Successful Relational Memory Binding

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