Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking

Oever, Michel C. van den; Goriounova, Natalia A.; Li, Ka Wan; Schors, Roel C. van der; Binnekade, R.; Schoffelmeer, Anton N. M.; Mansvelder, Huibert D.; Smit, August B.; Spijker, Sabine; Vries, Taco J. De

doi:10.1038/nn.2165

Cited by 178 publications

(151 citation statements)

References 48 publications

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“…A critical problem in opiate addiction is the occurrence of relapse. Here, we found that blockade of AMPAR endocytosis by intravenous infusion of GluR2-3Y before morphine injection inhibited the reinstatement of mCPP, and this result was supported by previous evidence which suggests that GluR2-3Y decreases cue-induced heroin reinstatement [15]. Collectively, GluR2 endocytosis may be needed in both drug-and cue-induced opiate relapse.…”

Section: Resultssupporting

confidence: 88%

“…Previous studies found that the endocytosis of AMPARs containing GluR2 in the NAc plays an important role in the expression of amphetamine-induced behavioral sensitization [21] and the long-term maintenance of mCPP [25]. Moreover, endocytosis in the BLA and in the ventral medial PFC is crucial for the reconsolidation of methamphetamine reward memory [26] and cue-induced heroin-seeking [15], respectively. However, no evidence has identified the brain regions in which the endocytosis of AMPARs is required for the acquisition and reinstatement of mCPP.…”

Section: Resultsmentioning

confidence: 98%

“…1A). The dosage of GluR2-3Y (1.5 nmol/ g) was used because previous studies have demonstrated that it is an effective dose to inhibit LTD [21], prevent the sensitized behavioral response [21], inhibit cue-induced relapse [15], and facilitate the extinction of mCPP [14].…”

Section: Resultsmentioning

confidence: 99%

“…However, no evidence has identified the brain regions in which the endocytosis of AMPARs is required for the acquisition and reinstatement of mCPP. Based on previous studies of drug-related memory, the hippocampus and ventral medial PFC may be the key brain regions for acquisition and reinstatement, respectively [15,27], and further investigations are needed.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, systemic administration of the AMPAR antagonist LY293558 blocks the development of morphine sensitization [11], and attenuates morphine-induced tolerance in mice [12] and in rats [13]. Recently, a few studies have also shown that the endocytosis of AMPARs is crucial for cue-induced reinstatement of heroin-seeking and the extinction of morphine-induced conditioned place preference (mCPP) [14,15].…”

Section: Introductionmentioning

confidence: 99%

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GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats

Lin

Zhang

2016

Neurosci. Bull.

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Accumulating evidence indicates that a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) are involved in the relapse to abused drugs. However, the role of AMPARs containing the GluR2 subunit in opiate addiction is still unclear. GluR2-3Y, an interfering peptide, prevents the endocytosis of AMPARs containing the GluR2 subunit. In this study, we explored the effect of intravenous injection of GluR2-3Y on the acquisition, expression, and reinstatement of morphine-induced conditioned place preference (mCPP) in rats. We found that infusion of GluR2-3Y (1.5 nmol/g) one hour before morphine during the conditioning phase inhibited the acquisition of mCPP, while an identical injection one hour before the post-conditioning test had no influence on the expression of mCPP. Injection of GluR2-3Y (1.5 nmol/g) after mCPP extinction blocked the morphine-induced reinstatement of mCPP. Our results strongly support the hypothesis that inhibition of AMPAR endocytosis provides a new target for the treatment of opiate addiction.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats

Lin

Zhang

2016

Neurosci. Bull.

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Toward a Developmental Psychopathology of Personality Disturbance: A Neurobehavioral Dimensional Model Incorporating Genetic, Environmental, and Epigenetic Factors

Lenzenweger

Depue

2016

Developmental Psychopathology

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We propose a dimensional model of personality disturbance in which personality pathology develops as an emergent product defined by extreme values on interacting subsets of several major personality traits. Being at the extreme ends of the continua described in this model has marked effects on the threshold for eliciting those traits under stimulus conditions: marked effects on the extent to which the environment affects the neurobiological functioning underlying the traits. To explore the nature of development of extreme values on these traits, each trait is discussed in terms of three major issues: (1) the neurobiological variables associated with the trait; (2) individual variation in this neurobiology as a function of genetic polymorphisms; and (3) the effects of environmental adversity on these neurobiological variables through the action of epigenetic processes. It is noted that gene–environment interaction appears to be dependent on two main factors: (1) both genetic and environmental variables appear to have the most profound and enduring effects when they exert their effects during early postnatal periods, times when the forebrain is undergoing exuberant experience‐expectant dendritic and axonal growth; and (2) environmental effects on neurobiology are strongly modified by individual differences in trait‐like functioning of neurobiological variables. We present this model of the development of personality disturbance for its heuristic potential as an organizing framework for understanding personality disturbance, one that emphasizes the interaction between environmental and neurobiological variables in the development of this form of psychopathology.

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Time‐dependent changes in the mouse hippocampal synaptic membrane proteome after contextual fear conditioning

et al. 2015

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A change in efficacy of hippocampal synapses is critical for memory formation. So far, the molecular analysis of synapses during learning has focused on small groups of proteins, whereas the dynamic global changes at these synapses have remained unknown. Here, we analyzed the temporal changes of the mouse hippocampal synaptic membrane proteome 1 and 4 h after contextual fear learning, comparing two groups; (1) a fear memory forming "delayed-shock" group and (2) a fear memory-deficient "immediate-shock" group. No changes in protein expression were observed 1 h after conditioning between the two experimental groups. However, 423 proteins were significantly regulated 4 h later of which 164 proteins showed a temporal regulation after a delayed shock and 273 proteins after the stress of an immediate shock. From the proteins that were differentially regulated between the delayed- and the immediate-shock groups at 4 h, 48 proteins, most prominently representing endocytosis, (amphiphysin, dynamin, and synaptojanin1), glutamate signaling (glutamate [NMDA] receptor subunit epsilon-1, disks large homolog 3), and neurotransmitter metabolism (excitatory amino acid transporter 1, excitatory amino acid transporter 2, sodium- and chloride-dependent GABA transporter 3) were regulated in both protocols, but in opposite directions, pointing toward an interaction of learning and stress. Taken together, this data set yields novel insight into diverse and dynamic changes that take place at hippocampal synapses over the time course of contextual fear-memory learning.

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Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking

Cited by 178 publications

References 48 publications

GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats

GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats

Toward a Developmental Psychopathology of Personality Disturbance: A Neurobehavioral Dimensional Model Incorporating Genetic, Environmental, and Epigenetic Factors

Time‐dependent changes in the mouse hippocampal synaptic membrane proteome after contextual fear conditioning

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