Prefrontal cortex as the site of estrogen's effect on cognition

Keenan, P. A.; Ezzat, Waleed H.; Ginsburg, Kenneth A.; Moore, Gregory J.

doi:10.1016/s0306-4530(01)00013-0

Cited by 208 publications

(136 citation statements)

References 47 publications

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“…In participants scoring high in cognitive disorganisation, high estradiol levels resulted in decreased confidence in false memories, while for participants scoring low on cognitive disorganisation, confidence in false memories was greater with higher estradiol levels. When considering meta-memory as a cognitive control process, the present data suggests that the beneficial effect of estradiol on cognitive control (Hjelmervik et al, 2012;Jacobs and D'Esposito, 2011;Keenan et al, 2001) might be specific to participants with high cognitive disorganisation, at least within the domain of memory.…”

Section: Estradiol Reduces False Memory Confidence In Highly Schizotymentioning

confidence: 83%

“…A significant association was found between levels of estradiol and clinical assessment scores; symptoms appeared to improve with increases in estradiol, and deteriorate when estradiol levels decreased. Further research has suggested that memory processes, including working memory (Hampson and Morley, 2013), verbal memory (Joffe et al, 2006), implicit memory (Maki et al, 2002), and discriminability (Keenan et al, 2001) can be enhanced with increased levels of estrogen (for recent reviews see Duarte-Guterman et al, in press; Frankfurt and Luine, in press). However, it is currently unclear whether the effect of estrogen on memory occurs because of direct effects of estrogen on memory or rather via hormonal effects on memory control functions, such as meta-memory processes (Colzato et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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High estradiol levels improve false memory rates and meta-memory in highly schizotypal women

Hodgetts

Hausmann

Weis

2015

Psychiatry Research

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(2015) 'High estradiol levels improve false memory rates and meta-memory in highly schizotypal women.', Psychiatry research., 229 (3). pp. 708-714. Further information on publisher's website:https://doi.org/10.1016/j.psychres. 2015.08.016 Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in Psychiatry Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be re ected in this document. Changes may have been made to this work since it was submitted for publication. Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractOverconfidence in false memories is often found in patients with schizophrenia and healthy participants with high levels of schizotypy, indicating an impairment of meta-cognition within the memory domain. In general, cognitive control is suggested to be modulated by natural fluctuations in estrogen. However, whether estrogen exerts beneficial effects on metamemory has not yet been investigated. The present study sought to provide evidence that high levels of schizotypy are associated with increased false memory rates and overconfidence in false memories, and that these processes may be modulated by natural differences in estradiol levels. Using the Deese-Roediger-McDermott paradigm, it was found that highly schizotypal participants with high estradiol produced significantly fewer false memories than those with low estradiol. No such difference was found within the low schizotypy participants. Highly schizotypal participants with high estradiol were also less confident in their false memories than those with low estradiol; low schizotypy participants with high estradiol were more confident. However, these differences only approached significance. These findings suggest that the beneficial effect of estradiol on memory and meta-memory observed in healthy participants is specific to highly schizotypal individuals and might be related to individual differences in baseline dopaminergic activity.

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Section: Estradiol Reduces False Memory Confidence In Highly Schizotymentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

High estradiol levels improve false memory rates and meta-memory in highly schizotypal women

Hodgetts

Hausmann

Weis

2015

Psychiatry Research

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“…As such, we were interested in examining the significantly associated variants in ESR1 (multi-SNP association) against the background of gene polymorphisms that do not appear associated with the diagnosis of PMDD but may nevertheless be involved. The Val158Met polymorphism in the COMT gene was selected for the following reasons: 1) COMT is involved in estrogen metabolism, performing O-methylation of 2-and 4-hydroxy estrogen metabolites (catecholestrogens); 2) the COMT gene contains estrogen response elements (Xie et al 1999), consistent with its regulation (decrease) by estradiol in vitro (Jiang et al 2003), an effect that is presumed to be mediated by ER alpha (Jiang et al 2003); 3) COMT is implicated in sex steroid associated cancers (Tanaka et al 2006;Sazci et al 2004); 4) COMT is responsible for regulating dopamine levels in the PFC, which are critical for modulation of cognitive function and "tuning" of the PFC (the ratio of task-related to task-unrelated neuronal firing), and the PFC is a brain region in which estradiol has been shown to regulate cerebral blood flow and function in humans (Berman et al 1997;Keenan et al 2001); 5) the COMT Val/Met polymorphism has been linked to the predisposition to several psychiatric disorders, including schizophrenia and OCD (Tunbridge et al in press;Karayiorgou et al 1997) and has been shown to moderate the effects of environmental factors in determining disease expression (Caspi et al 2005). The manifold interactions of COMT and estradiol and their convergence in areas of the brain critical in regulating mood and hypothesized as dysfunctional in PMDD (Rubinow et al in press) provided compelling justification for investigation of possible epistasis (gene-gene interactions).…”

Section: Discussionmentioning

confidence: 99%

Risk for Premenstrual Dysphoric Disorder Is Associated with Genetic Variation in ESR1, the Estrogen Receptor Alpha Gene

Huo

Straub

Roca

et al. 2007

Biological Psychiatry

144

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“…For instance, many reports have indicated a relationship between estrogen and cognitive function in humans and rodents (Warren and Juraska, 1997;Luine et al, 1998;Markowska, 1999;Fugger et al, 2000;Heikkinen et al, 2002;Iivonen et al, 2006). In postmenopausal women and aged rodents, estrogen treatment enhances cognitive function (Drake et al, 2000;Keenan et al, 2001;Sherwin, 2002;Markowska and Savonenko, 2002;Frick et al, 2002). The hormonal influences on cognitive processes appear to involve actions on the hippocampus and basal forebrain (McEwen and Alves, 1999).…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in the expression of ER-β mRNA in the female rat brain

Yamaguchi

Yuri

2007

Brain Research

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Estrogen is important for numerous physiological actions, most of which are mediated via the nuclear estrogen receptors (ERs), ER-α and ER-β, which modulate the transcription of target genes following estrogen binding. Estrogen functions change with age. In the present study, to reveal the effects of normal aging on ER-β expression in the brain, we examined ER-β expression at the transcriptional level using young (10 weeks), middle-aged (12 months) and old (24 months) intact female rats. In situ hybridization using a digoxigenin-labeled RNA probe was used to assess the number of ER-β mRNA-positive cells in each region in whole brain. ER-β mRNA-positive cells were detected throughout the brain in young female rats and were reduced in number in the olfactory bulb, cerebral cortex, hippocampus, accumbens nucleus, part of the amygdala and raphe nucleus of middle-aged rats, but did not decline further in number in aged animals. By contrast, the number of ER-β mRNA-positive cells was decreased in the hippocampus, caudate putamen, claustrum, accumbens nucleus, substantia nigra and cerebellum was not significantly different between young and middle-aged rats, but was decreased in old rats. These results indicate that the expression of ER-β mRNA in the female rat brain is differentially modulated during aging and that the changes are region specific.Section: 2) Nervous System Development, Regeneration and Aging

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Prefrontal cortex as the site of estrogen's effect on cognition

Cited by 208 publications

References 47 publications

High estradiol levels improve false memory rates and meta-memory in highly schizotypal women

High estradiol levels improve false memory rates and meta-memory in highly schizotypal women

Risk for Premenstrual Dysphoric Disorder Is Associated with Genetic Variation in ESR1, the Estrogen Receptor Alpha Gene

Age-related changes in the expression of ER-β mRNA in the female rat brain

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