Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep Disorders

Gao, Jiahui; Zhang, Lin; Zhu, Jingfang; Guo, Zhenxing; Lin, Miaoran; Bai, Linxin; Zheng, Peiyun; Li, Weilin; Huang, Jia; Liu, Zhizhen

doi:10.3390/brainsci13030497

Cited by 3 publications

(1 citation statement)

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“…WM is a memory system with a limited capacity for temporary storage and processing of information, which plays an important role in various cognitive tasks [ 2 ]. Patients with sleep disorders have a weak WM performance because of the reduced activation and functional connectivity in the prefrontal subregions [ 3 ]. TSD can disrupt many aspects of WM [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Cognitive Load Moderates the Effects of Total Sleep Deprivation on Working Memory: Evidence from Event-Related Potentials

et al. 2023

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Purpose: The function of working memory (WM) is impaired by total sleep deprivation (TSD) and cognitive load. However, it is unclear whether the load modulates the effect of TSD on WM. We conducted a pilot study to investigate the effects of 36 h of TSD on WM under different load levels. Materials and methods: Twenty-two male students aged 18–25 years were enrolled, who underwent two types of sleep conditions (baseline and 36 h TSD), where they performed two N-back WM tasks (one-back task and two-back task) with simultaneous electroencephalography recordings. Results: Repeated measures analysis of variance (ANOVA) indicated that, with the increasing load, the reaction time increased and the accuracy decreased. After TSD, the correct number per unit time decreased. The significant interaction effect of the P3 amplitudes between the load level and the sleep condition showed that the reduction in the amplitude of P3 in the two-back task due to TSD was more obvious than that in the one-back task. Conclusions: Our results provided evidence for the moderation of load on the impairment of TSD on WM. The degree of TSD-induced impairment for a higher load was greater than that for a lower load. The current study provides new insights into the mechanisms by which sleep deprivation affects cognitive function.

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Section: Introductionmentioning

confidence: 99%

Cognitive Load Moderates the Effects of Total Sleep Deprivation on Working Memory: Evidence from Event-Related Potentials

et al. 2023

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A scoping review of functional near-infrared spectroscopy biomarkers in late-life depression: Depressive symptoms, cognitive functioning, and social functioning

Tong,

Wang,

Wang

et al. 2024

Psychiatry Research: Neuroimaging

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Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

Liao,

Gao

et al. 2025

World J Psychiatry

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BACKGROUND Mild cognitive impairment (MCI) has a high risk of progression to Alzheimer’s disease. The disease is often accompanied by sleep disorders, and whether sleep disorders have an effect on brain function in patients with MCI is unclear. AIM To explore the near-infrared brain function characteristics of MCI with sleep disorders. METHODS A total of 120 patients with MCI (MCI group) and 50 healthy subjects (control group) were selected. All subjects underwent the functional near-infrared spectroscopy test. Collect baseline data, Mini-Mental State Examination, Montreal Cognitive Assessment scale, fatigue severity scale (FSS) score, sleep parameter, and oxyhemoglobin (Oxy-Hb) concentration and peak time of functional near-infrared spectroscopy test during the task period. The relationship between Oxy-Hb concentration and related indexes was analyzed by Pearson or Spearmen correlation. RESULTS Compared with the control group, the FSS score of the MCI group was higher (t = 11.310), and the scores of Pittsburgh sleep quality index, sleep time, sleep efficiency, nocturnal sleep disturbance, and daytime dysfunction were higher (Z = -10.518, -10.368, -9.035, -10.661, -10.088). Subjective sleep quality and total sleep time scores were lower (Z = -11.592, -9.924). The sleep efficiency of the MCI group was lower, and the awakening frequency, rem sleep latency period, total sleep time, and oxygen desaturation index were higher (t = 5.969, 5.829, 2.887, 3.003, 5.937). The Oxy-Hb concentration at T0, T1, and T2 in the MCI group was lower (t = 14.940, 11.280, 5.721), and the peak time was higher (t = 18.800, 13.350, 9.827). In MCI patients, the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index, sleep time, total sleep time, and sleep efficiency (r = -0.611, -0.388, -0.563, -0.356). It was positively correlated with sleep efficiency and total sleep time (r = 0.754, 0.650), and negatively correlated with oxygen desaturation index (r = -0.561) and FSS score (r = -0.526). All comparisons were P < 0.05. CONCLUSION Patients with MCI and sleep disorders have lower near-infrared brain function than normal people, which is related to sleep quality. Clinically, a comprehensive assessment of the near-infrared brain function of patients should be carried out to guide targeted treatment and improve curative effect.

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Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep Disorders

Cited by 3 publications

References 58 publications

Cognitive Load Moderates the Effects of Total Sleep Deprivation on Working Memory: Evidence from Event-Related Potentials

Cognitive Load Moderates the Effects of Total Sleep Deprivation on Working Memory: Evidence from Event-Related Potentials

A scoping review of functional near-infrared spectroscopy biomarkers in late-life depression: Depressive symptoms, cognitive functioning, and social functioning

Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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