Prefrontal cortex lesions and scopolamine impair attention performance of C57BL/6 mice in a novel 2-choice visual discrimination task

Dillon, Gregory M.; Shelton, Delia S.; McKinney, A. Patrick; Caniga, Michael; Marcus, Jacob; Ferguson, Mitchell T.; Kornecook, Thomas; Dodart, Jean-Cosme

doi:10.1016/j.bbr.2009.04.036

Cited by 30 publications

(17 citation statements)

References 58 publications

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“…These tasks include the widely employed five-choice serial reaction time (5-CSRT) task (Carli, et al, 1983; Hamilton, et al, 2014), as well as the one-choice (1-CSRT or ‘fixed-choice’) and two-choice (2-CSRT) variants (Anastasio, et al, 2011; Anastasio, et al, 2013; Cunningham, et al, 2013; Dalley, et al, 2002; Dillon, et al, 2009; Winstanley, et al, 2004a; Winstanley, et al, 2004b). These operant tasks entail a series of trials in which animals respond to a visual stimulus for delivery of a reinforcer.…”

Section: Measurements Of Rri In Animal Modelsmentioning

confidence: 99%

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications.

Hamilton

Littlefield

Anastasio³

et al. 2015

Personality Disorders: Theory, Research, and Treatment

140

110

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Impulsivity is a multi-faceted construct that is a core feature of multiple psychiatric conditions and personality disorders. However, progress in understanding and treating impulsivity in the context of these conditions is limited by a lack of precision and consistency in its definition and assessment. Rapid-response-impulsivity (RRI) represents a tendency toward immediate action that occurs with diminished forethought and is out of context with the present demands of the environment. Experts from the International Society for Research on Impulsivity (InSRI) met to discuss and evaluate RRI-measures in terms of reliability, sensitivity, and validity with the goal of helping researchers and clinicians make informed decisions about the use and interpretation of findings from RRI-measures. Their recommendations are described in this manuscript. Commonly-used clinical and preclinical RRI-tasks are described, and considerations are provided to guide task selection. Tasks measuring two conceptually and neurobiologically distinct types of RRI, “refraining from action initiation” (RAI) and “stopping an ongoing action” (SOA) are described. RAI and SOA-tasks capture distinct aspects of RRI that may relate to distinct clinical outcomes. The InSRI group recommends that: 1) selection of RRI-measures should be informed by careful consideration of the strengths, limitations, and practical considerations of the available measures; 2) researchers use both RAI and SOA tasks in RRI studies to allow for direct comparison of RRI types and examination of their associations with clinically relevant measures; and, 3) similar considerations should be made for human and non-human studies in an effort to harmonize and integrate pre-clinical and clinical research.

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Section: Measurements Of Rri In Animal Modelsmentioning

confidence: 99%

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications.

Hamilton

Littlefield

Anastasio³

et al. 2015

Personality Disorders: Theory, Research, and Treatment

140

110

View full text Add to dashboard Cite

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“…Infusion of scopolamine into the mPFC disrupted the ability of rats to complete trials but had no impact on attention measured by accuracy (Chudasama et al 2004). In mice, systemic administration of scopolamine disrupted sustained attention but the effect on attention was confounded with the decrease in motor activity and increased response time resulting from the scopolamine (Dillon et al 2009). In the same mouse study, administration of nicotine improved sustained attention.…”

Section: Introductionmentioning

confidence: 99%

The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition

Logue

Gould

2014

Pharmacology Biochemistry and Behavior

372

249

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Executive function is a collection of cognitive processes essential for higher order mental function. Processes involved in executive function include, but are not limited to, working memory, attention, cognitive flexibility, and impulse control. These complex behaviors are largely mediated by prefrontal cortical function but are modulated by dopaminergic, noradrenergic, serotonergic, and cholinergic input. The ability of these neurotransmitter systems to modulate executive function allows for adaption in cognitive behavior in response to changes in the environment. Because of the important role these neurotransmitter systems play in regulating executive function, changes in these systems can also have a grave impact on executive function. In addition, polymorphisms in genes associated with these neurotransmitters are associated with phenotypic differences in executive function. Understanding how these naturally occurring polymorphisms contribute to different executive function phenotypes will advance basic knowledge of cognition and potentially further understanding and treatment of mental illness that involve changes in executive function. In this review, we will examine the influence of dopamine, norepinephrine, serotonin, and acetylcholine on the following measures of executive function: attention, cognitive flexibility, and impulse control. We will also review the effects of polymorphisms in genes associated with these neurotransmitter systems on these measures of executive function.

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“…Previous work has confirmed that learning the association between an illuminated lever with reward is dependent on the integrity of the hippocampal formation, while attention performance in the same task is dependent on the medial prefrontal cortex [24]. For this reason, the current paradigm allows us to examine cognitive abilities dependent on two separate brain structures using the same paradigm.…”

Section: Resultsmentioning

confidence: 81%

“…A recently developed method for testing visual discrimination learning and attention performance was performed [24] and the methods are briefly outlined below.…”

Section: Methodsmentioning

confidence: 99%

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Lack of Tryptophan Hydroxylase-1 in Mice Results in Gait Abnormalities

et al. 2013

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The role of peripheral serotonin in nervous system development is poorly understood. Tryptophan hydroxylase-1 (TPH1) is expressed by non-neuronal cells including enterochromaffin cells of the gut, mast cells and the pineal gland and is the rate-limiting enzyme involved in the biosynthesis of peripheral serotonin. Serotonin released into circulation is taken up by platelets via the serotonin transporter and stored in dense granules. It has been previously reported that mouse embryos removed from Tph1-deficient mothers present abnormal nervous system morphology. The goal of this study was to assess whether Tph1-deficiency results in behavioral abnormalities. We did not find any differences between Tph1-deficient and wild-type mice in general motor behavior as tested by rotarod, grip-strength test, open field and beam walk. However, here we report that Tph1 (−/−) mice display altered gait dynamics and deficits in rearing behavior compared to wild-type (WT) suggesting that tryptophan hydroxylase-1 expression has an impact on the nervous system.

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Prefrontal cortex lesions and scopolamine impair attention performance of C57BL/6 mice in a novel 2-choice visual discrimination task

Cited by 30 publications

References 58 publications

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications.

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications.

The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition

Lack of Tryptophan Hydroxylase-1 in Mice Results in Gait Abnormalities

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