Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice
David H. Sarrazin,
Wilf Gardner,
Carole Marchese
et al.
Abstract:Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased circadian negative loop and decreased positive clock regulators expression in the medial prefrontal cortex (mPFC) of a mouse model of depression, and a subsequent clock countermodulation by the rapid antidepressant ketamine. Selective Bmal1KO in CaMK2a excitatory neurons revealed that the functional mPFC clock is an essential factor for t… Show more
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