Prefrontal grey and white matter neurometabolite changes after atomoxetine and methylphenidate in children with attention deficit/hyperactivity disorder: A 1H magnetic resonance spectroscopy study

Husarova, Veronika; Bittšanský, Michal; Ondrejka, Igor; Dobrota, Dušan

doi:10.1016/j.pscychresns.2014.03.003

Cited by 15 publications

(19 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 42 In line with our result, decreased NAA in the dorsolateral prefrontal cortex was found by Husarova et al after atomoxetine medication supporting the hypothesis that atomoxetine could decrease hyperactivation of dorsolateral prefrontal cortex neurons. 43 Our results should help to understand the mechanism by which aripiprazole exerts its function as a dopaminergic stabilizer being also able to influence the glutamine-glutamate-GABA cycle. This effect has also been shown in a recently published paper showing that aripiprazole treatment normalized patient values of striatal glutamate to control levels.…”

Section: Discussionmentioning

confidence: 83%

Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal 1H-NMR spectroscopy study at 11.7T

et al. 2017

View full text Add to dashboard Cite

Attention deficit hyperactivity disorder (ADHD), Tourette syndrome (TS) as well as obsessive compulsive disorder (OCD) are co-occurring neurodevelopmental diseases that share alterations of frontocortical neurometabolites. In this longitudinal study we investigated the behavioral and neurochemical effects of aripiprazole and riluzole treatment in juvenile spontaneously hypertensive rats (SHR), a model for ADHD. For neurochemical analysis we employed in vivo magnetic resonance spectroscopy (MRS). Spectra from voxels located at the central striatum and prefrontal cortex were acquired postnatally from day 35 to 50. In the SHR strain only, treatments reduced repetitive grooming and climbing behavior. The absolute quantification of cerebral metabolites in vivo using localized 1H-MRS at 11.7T showed significant alterations in SHR rats compared to controls (including glutamine, aspartate and total NAA). In addition, drug treatment reduced the majority of the detected metabolites (glutamate and glutamine) in the SHR brain. Our results indicate that the drug treatments might influence the hypothesized ‘hyperactive’ state of the cortico-striatal-thalamo-cortical circuitries of the SHR strain. Furthermore, we could show that behavioral changes correlate with brain region-specific alterations in neurometabolite levels in vivo. These findings should serve as reference for animal studies and for the analysis of neurometabolites in selected human brain regions to further define neurochemical alterations in neuropsychiatric diseases.

show abstract

Section: Discussionmentioning

confidence: 83%

Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal 1H-NMR spectroscopy study at 11.7T

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Furthermore, the number of medicated patients differed in previous studies. In addition to being linked to short-term neurometabolic changes in some studies (Carrey et al, 2002 ; MacMaster et al, 2003 ; Wiguna et al, 2012 ; Husarova et al, 2014 ), MPH exposure may also cause long-term changes (Nakao et al, 2011 ; Frodl and Skokauskas, 2012 ). In our study, patients had gone at least 6 months without ADHD-specific medication.…”

Section: Discussionmentioning

confidence: 99%

Normal Neurochemistry in the Prefrontal and Cerebellar Brain of Adults with Attention-Deficit Hyperactivity Disorder

Endres

Perlov

Maier

et al. 2015

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. In an attempt to extend earlier neurochemical findings, we organized a magnetic resonance spectroscopy (MRS) study as part of a large, government-funded, prospective, randomized, multicenter clinical trial comparing the effectiveness of specific psychotherapy with counseling and stimulant treatment with placebo treatment (Comparison of Methylphenidate and Psychotherapy Study). We report the baseline neurochemical data for the anterior cingulate cortex (ACC) and the cerebellum in a case–control setting. For the trial, 1,480 adult patients were contacted for participation, 518 were assessed for eligibility, 433 were randomized, and 187 were potentially eligible for neuroimaging. The control group included 119 healthy volunteers. Single-voxel proton MRS was performed. In the patient group, 113 ACC and 104 cerebellar spectra fulfilled all quality criteria for inclusion in statistical calculations, as did 82 ACC and 78 cerebellar spectra in the control group. We did not find any significant neurometabolic differences between the ADHD and control group in the ACC (Wilks’ lambda test: p = 0.97) or in the cerebellum (p = 0.62). Thus, we were unable to replicate earlier findings in this methodologically sophisticated study. We discuss our findings in the context of a comprehensive review of other MRS studies on ADHD and a somewhat skeptical neuropsychiatric research perspective. As in other neuropsychiatric disorders, the unclear nosological status of ADHD might be an explanation for false-negative findings.

show abstract

“…Lower NAA levels in WM has been observed in several brain disorders (Moffett, Ross, 2007) such as acute traumatic brain injury, brain ischemia, Alzheimer’s disease and multiple sclerosis (Danielsen and Ross, 1999). Psychoactive compounds can also reduce brain NAA levels, including atomoxetine treatment (Husarova et al , 2014) and after ingestion of ethanol or alcohol dehydrogenase inhibitors (Baslow, 2000). Therefore, decreased NAA levels in WM structures observed in the current sample could be related to axonal dysfunction, myelin pathology, psychotropic treatment, or all of them.…”

Section: Discussionmentioning

confidence: 99%

A proton spectroscopy study of white matter in children with autism

Hardan

Fung

Frazier

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

White matter abnormalities have been described in autism spectrum disorder (ASD) with mounting evidence implicating these alterations in the pathophysiology of the aberrant connectivity reported in this disorder. The goal of this investigation is to further examine white matter structure in ASD using proton magnetic resonance spectroscopy (1H MRS). Multi-voxel, short echo-time in vivo 1H MRS data were collected from 17 male children with ASD and 17 healthy age- and gender- matched controls. Key 1H metabolite ratios relative to phosphocreatine plus creatine were obtained from four different right and left white matter regions. Significantly lower N-acetylaspartate/creatine ratios were found in the anterior white matter regions of the ASD group when compared to controls. These findings reflect impairment in neuroaxonal white matter tissue and shed light on the neurobiologic underpinnings of white matter abnormalities in ASD by implicating an alteration in myelin and/or axonal development in this disorder.

show abstract

Prefrontal grey and white matter neurometabolite changes after atomoxetine and methylphenidate in children with attention deficit/hyperactivity disorder: A 1H magnetic resonance spectroscopy study

Cited by 15 publications

References 51 publications

Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal 1H-NMR spectroscopy study at 11.7T

Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal 1H-NMR spectroscopy study at 11.7T

Normal Neurochemistry in the Prefrontal and Cerebellar Brain of Adults with Attention-Deficit Hyperactivity Disorder

A proton spectroscopy study of white matter in children with autism

Contact Info

Product

Resources

About