Prefrontal gyrification in psychotic bipolar I disorder vs. schizophrenia

Nenadić, Igor; Maitra, Raka; Dietzek, Maren; Langbein, Kerstin; Smesny, Stefan; Sauer, Heinrich; Gaser, Christian

doi:10.1016/j.jad.2015.06.014

Cited by 58 publications

(65 citation statements)

References 27 publications

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“…Specifically for schizophrenia, our results are consistent with previous findings showing hypergyria within the PFC (Falkai et al, 2007;Vogeley et al, 2001;Nenadic et al, 2015). However, other studies reported hypogiria or preserved GI in the PFC of patients with schizophrenia (Bonnici et al, 2007;Cachia et al, 2007;Kulynych et al, 1997;Mancini-Marie et al, 2015;McIntosh et al, 2009;Nesvag et al, 2014;Palaniyappan and Liddle, 2012;Palaniyappan et al, 2011;Tepest et al, 2013;Highley et al, 2003).…”

Section: Discussionsupporting

confidence: 92%

“…Also, although the majority of the studies measured GI with a vertex-level approach, some others measured it across the entire lobe. Indeed, as suggested by Nenadic et al (2015), differences in resolution (higher for the vertex-level approach) could explained the abovementioned differences in GI in schizophrenia. Interestingly, it is worth mentioning that some of the studies were carried out in multi-affected families (Falkai et al, 2007;Vogeley et al, 2001) or in high risk individuals (Harris et al, 2004), and they also found increased GI in first-degree relatives of patients with schizophrenia (Falkai et al, 2007;Vogeley et al, 2001) and in individuals at high risk who subsequently develop schizophrenia (Harris et al, 2004).…”

Section: Discussionmentioning

confidence: 90%

“…Nonetheless, the evidence reporting the role of prefrontal cortical folding in schizophrenia have led to contrasting results (White and Hilgetag, 2011). Indeed, although PFC hypergyria has been reported in patients suffering from schizophrenia (Falkai et al, 2007;Vogeley et al, 2001;Nenadic et al, 2015), other authors have, in contrast, reported hypogyria (Bonnici et al, 2007;Cachia et al, 2007;Kulynych et al, 1997;Mancini-Marie et al, 2015;McIntosh et al, 2009;Nesvag et al, 2014;Palaniyappan et al, 2011;Palaniyappan and Liddle, 2012;Tepest et al, 2013) or no abnormalities (Highley et al, 2003). Similarly, the same mixed picture have been reported in first-episode patients with schizophrenia (Narr et al, 2004;Janssen et al, 2014;Wiegand et al, 2005), while only one study has investigated cortical gyrification in non-affective first-episode psychosis (FEP-NA) (Palaniyappan et al, 2013), showing hypogyria in the PFC.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Increased gyrification in schizophrenia and non affective first episode of psychosis

Zuliani

Delvecchio

Bonivento

et al. 2018

Schizophrenia Research

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Increased gyrification in schizophrenia and non affective first episode of psychosis

Zuliani

Delvecchio

Bonivento

et al. 2018

Schizophrenia Research

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“…A plausible explanation comes from post-mortem examinations (Selemon & Rajkowska, 2003), which found in dorsolateral prefrontal cortex altered packing with increased neuronal density in SCZ, as opposed to decreased neuronal density in BD, suggesting specific anatomical underpinnings for the two disorders. Future research in this direction, using novel morphometric parameters (such as local gyrification (Nenadic et al 2015b) and labelled cortical distance (Ratnanather et al 2014)) and advanced multimodal processing techniques (such as support vector machine algorithms), opens the door to the development of instruments with higher diagnostic specificity. Significant evidence on SCZ and BD can also come from trans-diagnostic analyses that look at common dimensions of functioning across the two disorders (e.g., Goodkind et al 2015), in line with the recent Research Domain Criteria.…”

mentioning

confidence: 99%

Neuroanatomical voxel-based profile of schizophrenia and bipolar disorder

Maggioni

Altamura

Brambilla

2016

Epidemiol Psychiatr Sci

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This Section of Epidemiology and Psychiatric Sciences appears in each issue of the Journal to stress the relevance of epidemiology for behavioral neurosciences, reporting the results of studies that explore the use of an epidemiological approach to provide a better understanding of the neural basis of major psychiatric disorders and, in turn, the utilisation of the behavioural neurosciences for promoting innovative epidemiological research.The ultimate aim is to help the translation of most relevant research findings into every-day clinical practice. These contributions are written in house by the journal's editorial team or commissioned by the Section Editor (no more than 1000 words, short unstructured abstract, 4 key-words, one Table or Although schizophrenia (SCZ) and bipolar disorder (BD) share elements of pathology (Ellison-Wright and Bullmore, 2009), the neural mechanisms underlying these disorders are still under investigation. Up until now, many neuroimaging studies investigated the brain structural differences of SCZ and BD compared with healthy controls (HC), trying to identify the possible neuroanatomical markers for the two disorders. However, just a few studies focused on the brain structural changes between the two diagnoses. The present review summarises the findings of the voxel-based grey matter (GM) comparisons between SCZ and BD, with the objective to highlight the possible consistent anatomical differences between the two disorders. While the comparisons between patients and HC highlighted overlapping areas of GM reduction in insula and anterior cingulate cortex, the SCZ-BD comparisons suggest the presence of more generalised GM deficits in SCZ compared with BD. Indeed, in a number of studies, SCZ patients showed lower GM volumes than BD patients in fronto-temporal cortex, thalamus, hippocampus and amygdala. Conversely, only a couple of studies reported GM deficits in BD compared with SCZ, both at the level of cerebellum. In summary, the two disorders exhibit both common and specific neuroanatomical characteristics, whose knowledge is mandatory to develop innovative diagnostic and treatment strategies. (Email: marcella.bellani@univr.it; paolo.brambilla1@unimi.it)Epidemiology and Psychiatric Sciences (2016), 25, 312-316.

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“…The LGI reflects the pattern and degree of cortical folding, some studies have reported that abnormal gyrification could be a more stable biomarker of brain disease than other neuroanatomical indices due to its putative state independence. The LGI can be measured with an automatically reconstructed cortical surface model (Nenadic et al, 2015). The LGI can quantify the early neural development of cortical connectivity in which the fiber tension of densely connected cortical regions forms gyri and sparsely connected regions move apart to become separated by sulci during the second trimester of pregnancy (Nanda et al, 2014).…”

Section: Neuroimage Analysis Techniquesmentioning

confidence: 99%

Brain Mapping Using Neuroimaging

Tae

Kang

Ham

et al. 2016

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Mapping brain structural and functional connections through the whole brain is essential for understanding brain mechanisms and the physiological bases of brain diseases. Although region specific structural or functional deficits cause brain diseases, the changes of interregional connections could also be important factors of brain diseases. This review will introduce common neuroimaging modalities, including structural magnetic resonance imaging (MRI), functional MRI (fMRI), diffusion tensor imaging, and other recent neuroimaging analyses methods, such as voxel-based morphometry, cortical thickness analysis, local gyrification index, and shape analysis for structural imaging. Tract-Based Spatial Statistics, TRActs Constrained by UnderLying Anatomy for diffusion MRI, and independent component analysis for fMRI also will also be introduced.

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Prefrontal gyrification in psychotic bipolar I disorder vs. schizophrenia

Cited by 58 publications

References 27 publications

Increased gyrification in schizophrenia and non affective first episode of psychosis

Increased gyrification in schizophrenia and non affective first episode of psychosis

Neuroanatomical voxel-based profile of schizophrenia and bipolar disorder

Brain Mapping Using Neuroimaging

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