Prefrontal hemodynamic changes produced by anodal direct current stimulation

Merzagora, Anna Caterina; Foffani, Guglielmo; Panyavin, Ivan; Mordillo-Mateos, Laura; Aguilar, Juan; Onaral, Banu; Oliviero, Antonio

doi:10.1016/j.neuroimage.2009.10.044

Cited by 156 publications

(116 citation statements)

References 43 publications

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“…Merzagora et al (2010) used functional near-infrared spectroscopy (fNIRS) for investigating the effects of bilateral prefrontal tDCS (1 mA for 10 ms; anode, lateral to Fp1; cathode, lateral to Fp2). They observed a local increase of the concentration of oxyhemoglobin, relatively focal and close to the anode.…”

Section: Effects Of Tdcs In Models and Imaging Studiesmentioning

confidence: 99%

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Keeser¹,

Meindl²,

Bor³

et al. 2011

J. Neurosci.

526

363

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Transcranial direct current stimulation (tDCS) has been proposed for experimental and therapeutic modulation of regional brain function. Specifically, anodal tDCS of the dorsolateral prefrontal cortex (DLPFC) together with cathodal tDCS of the supraorbital region have been associated with improvement of cognition and mood, and have been suggested for the treatment of several neurological and psychiatric disorders. Although modeled mathematically, the distribution, direction, and extent of tDCSmediated effects on brain physiology are not well understood. The current study investigates whether tDCS of the human prefrontal cortex modulates resting-state network (RSN) connectivity measured by functional magnetic resonance imaging (fMRI). Thirteen healthy subjects underwent real and sham tDCS in random order on separate days. tDCS was applied for 20 min at 2 mA with the anode positioned over the left DLPFC and the cathode over the right supraorbital region. Patterns of resting-state brain connectivity were assessed before and after tDCS with 3 T fMRI, and changes were analyzed for relevant networks related to the stimulation-electrode localizations. At baseline, four RSNs were detected, corresponding to the default mode network (DMN), the left and right frontal-parietal networks (FPNs) and the self-referential network. After real tDCS and compared with sham tDCS, significant changes of regional brain connectivity were found for the DMN and the FPNs both close to the primary stimulation site and in connected brain regions. These findings show that prefrontal tDCS modulates resting-state functional connectivity in distinct functional networks of the human brain.

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Section: Effects Of Tdcs In Models and Imaging Studiesmentioning

confidence: 99%

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Keeser¹,

Meindl²,

Bor³

et al. 2011

J. Neurosci.

526

363

View full text Add to dashboard Cite

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“…Following completion of the stimulation, participants had a rest period of approximately 16 min (Merzagora et al 2010). This was followed by a repetition of the Flanker Task and completion of the POMS-VAS.…”

Section: Procedures and Materialsmentioning

confidence: 99%

“…The profile of mood states (POMS) (McNair et al 1971) questionnaire provides a rapid method of assessing transient, fluctuating active mood states. It is an instrument particularly well suited to the present research because of its sensitivity to change in affective states.…”

Section: Mood Assessmentmentioning

confidence: 99%

“…It is an instrument particularly well suited to the present research because of its sensitivity to change in affective states. Six visual analogue scales (VAS) were derived from dimensional analysis of the 72-question, bipolar POMS questionnaire (Lorr et al 1982;McNair et al 1971;O'Connell et al 2012; O'Halloran et al 2004) (subsequently referred to as POMS-VAS). Using a VAS to evaluate current mood has been repeatedly demonstrated to be valid and reliable (e.g.…”

Section: Mood Assessmentmentioning

confidence: 99%

“…As neuroimaging studies (NIRS) have demonstrated that tDCS can produce electrode dependent changes in surface BOLD response (Merzagora et al 2010), and normalisation of left dlPFC hypoactivity has been observed following successful antidepressant treatment (Baxter et al 1989;Fales et al 2008;Kennedy et al 2001), this logic is not without merit. However, not unsurprisingly given the aetiology of MDD, observations regarding lateralised hypo-/hyper activity are inconstant and not confined to the dlPFC (for example, Brooks et al 2009;Drevets et al 2002;Greicius et al 2007a).…”

Section: Introductionmentioning

confidence: 99%

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Acute and repetitive fronto-cerebellar tDCS stimulation improves mood in non-depressed participants

et al. 2017

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second-daily (n = 21). In a second experiment, we separately investigated the influence of reversed polarity upon these same measures, in response to acute stimulation (n = 23) and repeated stimulation (n = 11). We observed a systematic elevation of mood in both active conditions following single and repeated tDCS, the latter of which displayed a progressive elevation of mood from baseline. No mood change was noted in response to either single or repeated stimulation in the sham condition. Frontocerebellar tDCS stimulation advantageously influences mood in healthy participants, with an accumulative and potentiated effect following successive stimulations. The possibility that frontocerebellar stimulation may provide a novel therapeutic adjunctive or pre-emptive intervention in stress-related disorders and mood-related psychopathologies should be considered.

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Prefrontal transcranial direct current stimulation alters activation and connectivity in cortical and subcortical reward systems: A tDCS‐fMRI study

Weber

Messing

Rao

et al. 2014

Human Brain Mapping

162

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Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique used both experimentally and therapeutically to modulate regional brain function. However, few studies have directly measured the aftereffects of tDCS on brain activity or examined changes in task-related brain activity consequent to prefrontal tDCS. To investigate the neural effects of tDCS, we collected fMRI data from 22 human subjects, both at rest and while performing the Balloon Analog Risk Task (BART), before and after true or sham transcranial direct current stimulation. TDCS decreased resting blood perfusion in orbitofrontal cortex and the right caudate and increased task-related activity in the right dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) in response to losses but not wins or increasing risk. Network analysis showed that whole-brain connectivity of the right ACC correlated positively with the number of pumps subjects were willing to make on the BART, and that tDCS reduced connectivity between the right ACC and the rest of the brain. Whole-brain connectivity of the right DLPFC also correlated negatively with pumps on the BART, as prior literature would suggest. Our results suggest that tDCS can alter activation and connectivity in regions distal to the electrodes.

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Prefrontal hemodynamic changes produced by anodal direct current stimulation

Cited by 156 publications

References 43 publications

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Acute and repetitive fronto-cerebellar tDCS stimulation improves mood in non-depressed participants

Prefrontal transcranial direct current stimulation alters activation and connectivity in cortical and subcortical reward systems: A tDCS‐fMRI study

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