Prefronto‐temporal white matter microstructural alterations 20 years after the diagnosis of type 1 diabetes mellitus

Yoon, Sujung; Kim, Jungyoon; Musen, Gail; Renshaw, Perry F.; Hwang, Jaeuk; Bolo, Nicolas R.; Kim, Jieun E.; Simonson, Donald C.; Weinger, Katie; Ryan, Christopher M.; Lyoo, In Kyoon; Jacobson, Alan M.

doi:10.1111/pedi.12574

Cited by 13 publications

(10 citation statements)

References 40 publications

(140 reference statements)

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“…A total of eight of the included studies consistently revealed the reduction of FA in T1DM [ 2 , 4 , 21 , 22 , 23 , 24 , 25 , 26 ], while four studies revealed higher MD, RD and AD in the white matter of T1DM patients compared to healthy controls ( Table 2 ) ( Figure 4 ) [ 4 , 20 , 21 , 26 ]. Most of the studies analysed DTI images using only voxel-wise brain analysis while other studies used both region of interest (ROI) and voxel-wise analysis [ 22 , 26 ], except for one study which used DTI tractography [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…The findings of included studies suggest that longer disease duration and increased HbA1c values correlated with the severity of microstructural abnormalities in optic radiation [ 2 , 23 ], posterior corona radiata [ 2 ], right internal capsule, anterior forceps, inferior frontal occipital fasciculi, splenium of the corpus callosum [ 2 ], uncinate fasciculi, subgenual white matter, superior, middle and inferior temporal gyri, superior longitudinal fasciculi, and occipital white matter [ 20 , 21 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…In young adults, there was a negative relationship between FA values and current HbA1c. However, long-lasting glycaemic control levels, severe hypoglycaemia, and the duration of disease were not correlated with FAs in the T1DM group [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…These findings suggest that long-standing T1DM may cause microstructural changes in the posterior cerebrum. In addition, the reduced FA values in the splenium of the corpus callosum, optic radiations, and the posterior corona radiata with posterior cortical atrophy are found to be correlated with volume loss in the occipital cortex in T1DM patients, which may suggest the effects of T1DM on executive functions and psychomotor speed [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review

et al. 2021

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Type 1 and type 2 diabetes mellitus have an impact on the microstructural environment and cognitive functions of the brain due to its microvascular/macrovascular complications. Conventional Magnetic Resonance Imaging (MRI) techniques can allow detection of brain volume reduction in people with diabetes. However, conventional MRI is insufficiently sensitive to quantify microstructural changes. Diffusion Tensor Imaging (DTI) has been used as a sensitive MRI-based technique for quantifying and assessing brain microstructural abnormalities in patients with diabetes. This systematic review aims to summarise the original research literature using DTI to quantify microstructural alterations in diabetes and the relation of such changes to cognitive status and metabolic profile. A total of thirty-eight published studies that demonstrate the impact of diabetes mellitus on brain microstructure using DTI are included, and these demonstrate that both type 1 diabetes mellitus and type 2 diabetes mellitus may affect cognitive abilities due to the alterations in brain microstructures.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review

et al. 2021

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“…It should also be noted that alterations in brain white matter have been observed among individuals with Type I and Type II diabetes (Moghaddam, Sherbaf, & Aarabi, ; Yoon et al, ). The present analyses included two individuals with diabetes.…”

Section: Discussionmentioning

confidence: 99%

Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE‐FRDA study

Selvadurai

Corben

Delatycki

et al. 2020

Human Brain Mapping

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Friedreich ataxia is a progressive neurodegenerative disorder with reported abnormalities in cerebellar, brainstem, and cerebral white matter. White matter structure can be measured using in vivo neuroimaging indices sensitive to different white matter features. For the first time, we examined the relative sensitivity and relationship between multiple white matter indices in Friedreich ataxia to more richly characterize disease expression and infer possible mechanisms underlying the observed white matter abnormalities. Diffusion‐tensor, magnetization transfer, and T1‐weighted structural images were acquired from 31 individuals with Friedreich ataxia and 36 controls. Six white matter indices were extracted: fractional anisotropy, diffusivity (mean, axial, radial), magnetization transfer ratio (microstructure), and volume (macrostructure). For each index, whole‐brain voxel‐wise between‐group comparisons and correlations with disease severity, onset age, and gene triplet‐repeat length were undertaken. Correlations between pairs of indices were assessed in the Friedreich ataxia cohort. Spatial similarities in the voxel‐level pattern of between‐group differences across the indices were also assessed. Microstructural abnormalities were maximal in cerebellar and brainstem regions, but evident throughout the brain, while macroscopic abnormalities were restricted to the brainstem. Poorer microstructure and reduced macrostructural volume correlated with greater disease severity and earlier onset, particularly in peri‐dentate nuclei and brainstem regions. Microstructural and macrostructural abnormalities were largely independent. Reduced fractional anisotropy was most strongly associated with axial diffusivity in cerebral tracts, and magnetization transfer in cerebellar tracts. Multiple mechanisms likely underpin white matter abnormalities in Friedreich ataxia, with differential impacts in cerebellar and cerebral pathways.

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Diabetes‐related clinical and microstructural white matter changes in patients with Alzheimer's disease

Sumbul‐Sekerci,

Velioglu,

Sekerci

2024

Brain and Behavior

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AimAlthough there exists substantial epidemiological evidence indicating an elevated risk of dementia in individuals with diabetes, our understanding of the neuropathological underpinnings of the association between Type‐2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) remains unclear. This study aims to unveil the microstructural brain changes associated with T2DM in AD and identify the clinical variables contributing to these changes.MethodsIn this retrospective study involving 64 patients with AD, 31 individuals had concurrent T2DM. The study involved a comparative analysis of diffusion tensor imaging (DTI) images and clinical features between patients with and without T2DM. The FSL FMRIB software library was used for comprehensive preprocessing and tractography analysis of DTI data. After eddy current correction, the “bedpost” model was utilized to model diffusion parameters. Linear regression analysis with a stepwise method was used to predict the clinical variables that could lead to microstructural white matter changes.ResultsWe observed a significant impairment in the left superior longitudinal fasciculus (SLF) among patients with AD who also had T2DM. This impairment in patients with AD and T2DM was associated with an elevation in creatine levels.ConclusionThe white matter microstructure in the left SLF appears to be sensitive to the impairment of kidney function associated with T2DM in patients with AD. The emergence of AD in association with T2DM may be driven by mechanisms distinct from the typical AD pathology. Compromised renal function in AD could potentially contribute to impaired white matter integrity.

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Prefronto‐temporal white matter microstructural alterations 20 years after the diagnosis of type 1 diabetes mellitus

Cited by 13 publications

References 40 publications

Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review

Investigating Brain Microstructural Alterations in Type 1 and Type 2 Diabetes Using Diffusion Tensor Imaging: A Systematic Review

Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE‐FRDA study

Diabetes‐related clinical and microstructural white matter changes in patients with Alzheimer's disease

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