Pregabalin Assay in a Patient with Widespread Neuropathic Pain and Late Onset Gluten Intolerance: Table 1

Abstract

Although the results obtained are encouraging, the wide spectrum of effects and interactions of various drugs in malabsorption would suggest that therapy of any kind should be considered at individual level and monitored with blood assays.

The Absorption Profile of Pregabalin in Chronic Pancreatitis

“…In coeliac disease, there are a number of changes in the gut that could affect drug exposure, for example, rate of gastric emptying, intraluminal pH changes and stunted small intestinal villi. However, it was demonstrated that the blood levels measured in this patient did not differ from healthy male volunteers enrolled in previous studies . The present study is the first study performed in patients with chronic pancreatitis to investigate whether chronic pancreatitis could lead to a different absorption of pregabalin.…”

“…This was supported by Shoji et al., who demonstrated that renal function (measured as creatinine clearance) was a clinically influential covariate on CL/F in healthy individuals, patients with impaired renal function, patients with post‐herpetic neuralgia or diabetic neuropathy. Recently, a case report was published on pregabalin assay in a patient with widespread neuropathic pain and late‐onset gluten intolerance . In coeliac disease, there are a number of changes in the gut that could affect drug exposure, for example, rate of gastric emptying, intraluminal pH changes and stunted small intestinal villi.…”