Pregabalin: Dose-Response Relationship in Generalized Anxiety Disorder

Boschen, Mark Justin

doi:10.1055/s-0031-1291176

Cited by 10 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ginseng total saponin showed dose-dependent, incremental antihyperalgesic effects in the incisional pain model [3] . However, in the present study, ginsenoside Rf-MWT had a curvilinear-shaped dose–response relationship, similar to pregabalin, buprenorphine, and haloperidol, the effects of which were more pronounced at medium rather than high dosages [32] , [33] , [34] . The peak effective dose of ginsenoside Rf in the present study was 1.5 mg/kg, and achieved a significant antinociceptive effect.…”

Section: Discussionmentioning

confidence: 78%

Antinociceptive and anti-inflammatory effects of ginsenoside Rf in a rat model of incisional pain

Kim

Kang

Baek

et al. 2018

Journal of Ginseng Research

View full text Add to dashboard Cite

BackgroundGinseng saponin has long been used as a traditional Asian medicine and is known to be effective in treating various kinds of pain. Ginsenoside Rf is one of the biologically active saponins found in ginseng. We evaluated ginsenoside Rf’s antinociceptive and anti-inflammatory effects, and its mechanism of action on adrenergic and serotonergic receptors, in an incisional pain model.MethodsMechanical hyperalgesia was induced via plantar incision in rats followed by intraperitoneal administration of increasing doses of ginsenoside Rf (vehicle, 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg, and 2 mg/kg). The antinociceptive effect was also compared in a Positive Control Group that received a ketorolac (30 mg/kg) injection, and the Naïve Group, which did not undergo incision. To evaluate the mechanism of action, rats were treated with prazosin (1 mg/kg), yohimbine (2 mg/kg), or ketanserin (1 mg/kg) prior to receiving ginsenoside Rf (1.5 mg/kg). The mechanical withdrawal threshold was measured using von Frey filaments at various time points before and after ginsenoside Rf administration. To evaluate the anti-inflammatory effect, serum interleukin (IL)-1β, IL-6, and tumor necrotizing factor-α levels were measured.ResultsGinsenoside Rf increased the mechanical withdrawal threshold significantly, with a curvilinear dose–response curve peaking at 1.5 mg/kg. IL-1β, IL-6, and tumor necrotizing factor-α levels significantly decreased after ginsenoside Rf treatment. Ginsenoside Rf’s antinociceptive effect was reduced by yohimbine, but potentiated by prazosin and ketanserin.ConclusionIntraperitoneal ginsenoside Rf has an antinociceptive effect peaking at a dose of 1.5 mg/kg. Anti-inflammatory effects were also detected.

show abstract

Section: Discussionmentioning

confidence: 78%

Antinociceptive and anti-inflammatory effects of ginsenoside Rf in a rat model of incisional pain

Kim

Kang

Baek

et al. 2018

Journal of Ginseng Research

View full text Add to dashboard Cite

show abstract

“…In addition to safety data contained in the clinical trials cited above, four additional citations summarised results of studies with safety as the primary outcome (Frame et al, 2009; Hindmarch et al, 2005a, 2005b; Rubio et al, 2011). Finally, 11 review articles were identified that specifically evaluated the safety and efficacy of pregabalin in the treatment of GAD (Bandelow et al, 2007; Bech, 2007; Boschen, 2011, 2012; Frampton and Foster, 2006; Holsboer-Trachsler and Prieto, 2013; Lauria-Horner and Pohl, 2003; Montgomery, 2006; Montgomery and Kasper, 2010; Owen, 2007; Wensel et al, 2012). These articles were each reviewed to determine whether they contained additional citations not identified in the MEDLINE and PsychINFO literature searches.…”

Section: Methodsmentioning

confidence: 99%

Efficacy and safety of pregabalin in generalised anxiety disorder: A critical review of the literature

et al. 2015

View full text Add to dashboard Cite

The aim of this review is to summarise the literature on the efficacy and safety of pregabalin for the treatment of generalised anxiety disorder (GAD). Of 241 literature citations, 13 clinical trials were identified that were specifically designed to evaluate the efficacy and safety of pregabalin in GAD, including 11 randomised double-blind trials and two open-label studies. Pregabalin efficacy has been consistently demonstrated across the licensed dose range of 150-600 mg/day. Efficacy has been reported for pregabalin monotherapy in elderly patients with GAD, patients with severe anxiety, and for adjunctive therapy when added to a selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitor in patients who have failed to respond to an initial course of antidepressant therapy. The two most common adverse events with pregabalin are somnolence and dizziness, both of which appear to be dose-related. Pregabalin appears to have a low potential for causing withdrawal symptoms when long-term therapy is discontinued; however, tapering over the course of at least one week is recommended. A review of available evidence indicates that pregabalin is a well-tolerated and consistently effective treatment for GAD, with a unique mechanism of action that makes it a useful addition to the therapeutic armamentarium.

show abstract

“…In this concept of the dose-response relationship, an agent may often show inhibitory activity at higher doses [32]. Many drugs, such as haloperidol, buprenorphine, cannabidiol, and pregabalin, show a bell-shaped dose response [33,34,35,36]. Although this concept cannot sufficiently be explained in this paper, this dose-response relationship indicates that a response could only be achieved at a certain concentration, and this could make it difficult to use Rg3 clinically as a single agent.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive Effects of Ginsenoside Rg3 in a Rat Model of Incisional Pain

Ahn

Choi²,

Kang³

et al. 2016

Eur Surg Res

View full text Add to dashboard Cite

Background: Ginsenoside Rg3 is an extract of total ginseng saponins, which accounts for 4.7% of all saponins. This study aimed to identify the mechanisms of the antinociceptive effects of ginsenoside Rg3. Methods: Rats were randomly divided into six groups, which were treated with vehicle or 0.5, 1, 1.5, 2, or 4 mg/kg of ginsenoside Rg3 intraperitoneally 2 h after a plantar incision was made. To evaluate the mechanisms of antinociceptive effects, the rats were intraperitoneally injected with naloxone 5 mg/kg, atropine 1 mg/kg, yohimbine 2 mg/kg, mecamylamine 1 mg/kg, prazosin 1 mg/kg, and dexmedetomidine 5 μg/kg. Hyperalgesia produced by the plantar incision was assessed using von Frey filaments 1 day before the incision (BI) and 2 h after the plantar incision (AP); this measurement was repeated at 15, 30, 45, 60, 80, 100 and 120 min, and 24 and 48 h after the injection of ginsenoside Rg3. Serum interleukin-1β (IL-1β) and interleukin-6 (IL-6) levels were measured 1 day before incision and 120 min, 24 h, and 48 h after the injection of ginsenoside Rg3 or vehicle. Results: The mechanical withdrawal threshold (MWT) significantly increased in the group that received ginsenoside Rg3. The dose-MWT response showed a curvilinear, bell-shaped relationship. The maximum MWT was found with the administration of ginsenoside Rg3 at 1.5 mg/kg; MWT decreased to 2 and 4 mg/kg. Yohimbine diminished the analgesic effect of ginsenoside Rg3. Prazosin and dexmedetomidine increased the analgesic effect of ginsenoside Rg3. IL-1β and IL-6 appeared significantly lower relative to control group. Conclusions: Ginsenoside Rg3 has an analgesic effect with a curvilinear dose-response relationship. Alpha 2 adrenergic receptor appeared to be related to the analgesic effect of ginsenoside Rg3. Also, the anti-inflammatory effect of ginsenoside Rg3 could be related to its analgesic effect.

show abstract

Pregabalin: Dose-Response Relationship in Generalized Anxiety Disorder

Abstract: Implications for psychiatric practice, limitations of the methodology and avenues for future research are discussed.

Cited by 10 publications

References 27 publications

Antinociceptive and anti-inflammatory effects of ginsenoside Rf in a rat model of incisional pain

Antinociceptive and anti-inflammatory effects of ginsenoside Rf in a rat model of incisional pain

Efficacy and safety of pregabalin in generalised anxiety disorder: A critical review of the literature

Antinociceptive Effects of Ginsenoside Rg3 in a Rat Model of Incisional Pain

Contact Info

Product

Resources

About