Pregabalin for the treatment of postsurgical pain

Durkin, Brian; Page, Christopher R.; Glass, Peter S. A.

doi:10.1517/14656566.2010.526106

Cited by 48 publications

(39 citation statements)

References 56 publications

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“…Pregabalin has analgesic, anticonvulsant, and anxiolytic effects [5,6]. Several studies have demonstrated the efficacy of oral pregabalin on post-operative analgesia and reduction of parenteral analgesics [7][8][9]. Oral pregabalin attenuates pressor response to laryngoscopy and endotracheal intubation [10,11].…”

Section: Introductionmentioning

confidence: 99%

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

Samal

Pattnaik

Swain

et al. 2017

Asian J Pharm Clin Res

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Objectives: The airway instrumentation of direct laryngoscopy and tracheal intubation is powerful noxious stimuli that should be attenuated by appropriate premedication, smooth induction, and rapid intubation. This study compared the efficacy intravenous dexmedetomidine and oral pregabalin premedication for attenuation of hemodynamic pressor response to laryngoscopy and intubation.Methods: A total of 60 patients of age group 20-50 years scheduled for elective surgeries under general anesthesia with American Society of Anesthesiologists physical Status I and II were divided into two groups each of 30. Group D received intravenous dexmedetomidine 1 mcg/kg over 10 minutes before induction, and Group P received oral pregabalin 150 mg 1 hr before intubation. Parameters observed were heart rate (HR) and mean arterial pressure (MAP) at baseline, after induction, immediately after intubation and then 5, 10, 15, and 30 minutes thereafter.Results: Attenuation of HR in group dexmedetomidine (78.12±10.0/minutes) immediately after intubation was statistically significant than group pregabalin (89.76±10.45/minutes). MAP significantly (p<0.05) decreased after intubation with dexmedetomidine. As compared to oral pregabalin, attenuation of HR and MAP was statistically significant till 30 minutes after intubation with intravenous dexmedetomidine. Conclusion:Intravenous dexmedetomidine 1 µg/kg is more effective than oral pregabalin 150 mg in attenuating hemodynamic response to laryngoscopy and orotracheal intubation.

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Section: Introductionmentioning

confidence: 99%

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

Samal

Pattnaik

Swain

et al. 2017

Asian J Pharm Clin Res

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“…Durkin et al in their review, had stated that pregabalin is a safe and effective medication that might benefit the surgery involving more neuropathic-type acute pain than acute inflammatory pain, resulting in a decrease in the perioperative opioid consumption [4]. It was also suggested in another recent review that was published when our study was near complete, that pain scores at 24 h following surgery were affected 1 % by the pregabalin dose and 32 % by the surgical type-again lending credence that more neuropathic and painful surgery may allow for a greater pregabalin effect [16].…”

Section: Discussionmentioning

confidence: 99%

“…sparing effects and prevention of chronic postsurgical pain [4]. COX-2 inhibitors are also being studied for their antiinflammatory analgesic effect either alone or in combination with gabapentinoids for postoperative analgesia [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The effect of pregabalin and celecoxib on the analgesic requirements after laparoscopic cholecystectomy: a randomized controlled trial

et al. 2015

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“…Efficacy of oral pregabalin postoperative analgesia and reduction of parenteral analgesics has been demonstrated in several studies. [13,14]. Only few data are published in literature about the cardiovascular effects of pregabalin on the patients undergoing surgery.…”

Section: Name and Address Of Corresponding Authormentioning

confidence: 99%

Pre-emptive Use of Oral Pregabalin Attenuates the Pressor Response of Laryngoscopy and Endotracheal Intubation: A Double Blind Randomized Placebo Controlled Study

2016

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Background: Laryngoscopy and intubation may cause undesirable increase in blood pressure and heart rate. The aim of the present study was to investigate the effect of Pregabalin premedication on hemodynamic responses to laryngoscopy and intubation. Methods: Sixty ASA physical status I or II patients undergoing elective surgery under general anesthesia were randomly allocated into two equal groups who received either oral Pregabalin 150 mg (Group PB)or placebo (Group PL)1 hour prior to surgery. Heart rate, Systolic, Diastolic and Mean arterial blood pressures were recorded preoperative, at laryngoscopy and 0,1,3,5 and 10 minutes after tracheal intubation. Results: Demographic data and base-line values for Heart rate, Systolic, Diastolic and Mean arterial blood pressures were comparable between groups. During laryngoscopy and intubation there was significant attenuation of SBP, DBP and MBP in PB group as compared to PL group. Although increase in heart rate was less in pregabalin group during laryngoscopy and intubation but it was not statistically significant. Conclusion:In the present study design, oral Pregabalin premedication at a dose of 150 mg one hour prior to surgery attenuates pressor response associated with laryngoscopy and endotracheal intubation but not the tachycardia significantly.

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Pregabalin for the treatment of postsurgical pain

Cited by 48 publications

References 56 publications

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

The effect of pregabalin and celecoxib on the analgesic requirements after laparoscopic cholecystectomy: a randomized controlled trial

Pre-emptive Use of Oral Pregabalin Attenuates the Pressor Response of Laryngoscopy and Endotracheal Intubation: A Double Blind Randomized Placebo Controlled Study

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