Pregabalin treatment of three cases with brachioradial pruritus

Atış, Güldehan; Kaya, Başak Bilir

doi:10.1111/dth.12459

Cited by 18 publications

(13 citation statements)

References 12 publications

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“…Pregabalin has been previously used in various clinical conditions for the treatment of pruritus in dermatology. pregabalin daily in two of three cases with brachioradial pruritus, while a dose of 225 mg was needed in the third patient [11]. In thirty patients with prurigo nodularis, 75 mg of pregabalin daily was used for three months, which provided satisfactory relief in 23 (76%) patients [12].…”

Section: Discussionmentioning

confidence: 99%

Treatment of notalgia paresthetica with low dose pregabalin: Retrospective evaluation of 13 patients

Şener¹,

Kılınç²,

Akbaş³

2021

Our Dermatol Online

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Background: Notalgia paresthetica (NP) is a sensory neuropathic syndrome characterized by chronic itching of the unilateral mid-back. Topical and systemic symptomatic treatments have been used to date. In recent years, neuropathic pain medicine has been used to relieve the symptoms of the disease. The aim of this study was to determine the effectiveness of pregabalin in notalgia paresthetica. Materials and Methods: In this study, the files of the patients with a diagnosis of NP and treated with pregabalin for at least one month in the period between 2016 and 2018 were evaluated retrospectively. Results: Thirteen cases of NP treated with low-dose (up to 150 mg/day) pregabalin were evaluated, and 9 (70%) patients exhibited a good response in this retrospective study. All patients were female and the mean age was 53.5 (31–71) ± 10.3 years. The mean disease duration was 6.1 (1–10) ± 4.1 years. Conclusion: Treatment with low-dose pregabalin may be a good option for the symptomatic treatment of NP.

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Section: Discussionmentioning

confidence: 99%

Treatment of notalgia paresthetica with low dose pregabalin: Retrospective evaluation of 13 patients

Şener¹,

Kılınç²,

Akbaş³

2021

Our Dermatol Online

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“…Seventy-five percent of patients attained complete resolution with 75 mg pregabalin twice daily, while 25% required 225 mg daily. 26,27 In one case, lamotrigine 200 mg daily produced symptomatic resolution. 25 Similarly, in another case, carbamazepine demonstrated symptomatic improvement, however no dose was reported.…”

Section: Systemic Medicationsmentioning

confidence: 98%

“…5,10 Other anticonvulsants used for BRP include pregabalin, lamotrigine, and carbamazepine. 5,25,26 One prospective study and one case report (n=4) noted improvement in pruritus with pregabalin. Seventy-five percent of patients attained complete resolution with 75 mg pregabalin twice daily, while 25% required 225 mg daily.…”

Section: Systemic Medicationsmentioning

confidence: 99%

Treatment of Brachioradial Pruritus: A Systematic Review

2019

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Importance: Brachioradial pruritus (BRP) is a poorly understood disease and can severely impact quality of life. However, there is currently no clear treatment. Objective: To identify effective behavioral, topical, oral, and invasive treatment options for BRP, and to discuss the quality of the data currently found in the literature. Evidence Review: The PubMed and CINAHL databases were systematically reviewed for articles from 1968 to the present containing search terms “brachioradial OR solar OR forearm AND pruritus OR itching.” Results were narrowed to articles written in English, focusing specifically on BRP, and that stated precise treatment modalities. Evidence quality was determined based on the study type. Findings: Thirty-six articles discussing treatments for BRP are included in this review with a total 399 patients. Six studies (n=68) report on the efficacy of capsaicin cream, eight studies (n=26) on oral gabapentin 300 mg daily to six times daily and four studies (n=98) on sun protection. The remaining articles comprise of low-quality, small-scale studies on further oral medications, physical therapy, minimally-invasive procedures, and surgery. Conclusions and Relevance: Low-quality evidence supports the use of sun protection, topical capsaicin, or oral gabapentin as effective therapeutic modalities for BRP. Clinicians should be aware of possible underlying cervical spine pathology and include thorough imaging as part of BRP work-up. Further high-quality studies on BRP treatments would help elucidate clear management for this disorder.

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“…32 Although initially developed for the treatment of chronic pain syndromes such as diabetic neuropathy, these drugs have been reported to help treat various forms of itch, including neuropathic itch (ie, brachioradial pruritus and notalgia paresthetica), uremic itch, and prurigo nodularis. [34][35][36] We recommend the use of these medications when treating neuropathic pruritus or itch of unknown origin. Nonresponders of gabapentin should be tried on pregabalin and vice versa, because patients may respond to one drug and not the other.…”

Section: Anticonvulsantsmentioning

confidence: 99%

Practical Approach for the Diagnosis and Treatment of Chronic Pruritus

Golpanian¹,

González²,

Yosipovitch³

2020

The Journal for Nurse Practitioners

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Chronic itch is a common condition that affects the quality of life of many patients and can often be difficult to treat. When managing a patient with itch, the first step requires identification of the underlying cause, which may be dermatologic or nondermatologic in nature. The process begins with a thorough history and physical examination, which may or may not be followed by laboratory tests and imaging. The appropriate treatment for each patient should be considered based on the diagnosis, severity of itch, and individual patient preference. Treatment options range from topical treatments, which may be indicated for more mild types of itch, to systemic treatments, which may be indicated for itch that is more ubiquitous and debilitating in nature. Within the last decade, developments in our understanding of itch pathophysiology has led to new treatment options on the horizon that consist of more targeted medications, including monoclonal antibodies and opioid modulators.

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Pregabalin treatment of three cases with brachioradial pruritus

Cited by 18 publications

References 12 publications

Treatment of notalgia paresthetica with low dose pregabalin: Retrospective evaluation of 13 patients

Treatment of notalgia paresthetica with low dose pregabalin: Retrospective evaluation of 13 patients

Treatment of Brachioradial Pruritus: A Systematic Review

Practical Approach for the Diagnosis and Treatment of Chronic Pruritus

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