Preglomerular and postglomerular basal diameter changes and reactivity to angiotensin II in obese rats

Roos, Marjon H.; Eringa, Etto C.; Rodijnen, William F. van; Lambalgen, Ton A. van; Wee, Piet M. ter; Tangelder, G. J.

doi:10.1111/j.1463-1326.2007.00827.x

Cited by 9 publications

(4 citation statements)

References 37 publications

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“…This leads to an increase of the hydrostatic pressure in the glomerular capillaries, which contributes to an elevated GFR and albuminuria. However, it has been shown that ANG II can exaggerate the vasoconstriction response of the efferent arteriole in obese rats, favoring glomerular dysfunction (49). In our study, since losartan, an AT 1 angiotensin receptor antagonist, prevents the increased GFR and restores the cortical blood flow, we might hypothesize that ANG II acts through the AT 1 receptor, which has been demonstrated to be distributed on renal efferent arteriole (17,29).…”

Section: Discussionmentioning

confidence: 64%

Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging

Declèves

Rychak

Smith

et al. 2013

American Journal of Physiology-Renal Physiology

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Declèves AE, Rychak JJ, Smith DJ, Sharma K. Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging. Am J Physiol Renal Physiol 305: F1343-F1351, 2013. First published September 18, 2013 doi:10.1152/ajprenal.00326.2013.-Obesity-related kidney disease occurs as a result of complex interactions between metabolic and hemodynamic effects. Changes in microvascular perfusion may play a major role in kidney disease; however, these changes are difficult to assess in vivo. Here, we used perfusion ultrasound imaging to evaluate cortical blood flow in a mouse model of high-fat diet-induced kidney disease. C57BL/6J mice were randomized to a standard diet (STD) or a high-fat diet (HFD) for 30 wk and then treated either with losartan or a placebo for an additional 6 wk. Noninvasive ultrasound perfusion imaging of the kidney was performed during infusion of a microbubble contrast agent. Blood flow within the microvasculature of the renal cortex and medulla was derived from imaging data. An increase in the time required to achieve full cortical perfusion was observed for HFD mice relative to STD. This was reversed following treatment with losartan. These data were concurrent with an increased glomerular filtration rate in HFD mice compared with STD-or HFD-losartan-treated mice. Losartan treatment also abrogated fibro-inflammatory disease, assessed by markers at the protein and messenger level. Finally, a reduction in capillary density was found in HFD mice, and this was reversed upon losartan treatment. This suggests that alterations in vascular density may be responsible for the elevated perfusion time observed by imaging. These data demonstrate that ultrasound contrast imaging is a robust and sensitive method for evaluating changes in renal microvascular perfusion and that cortical perfusion time may be a useful parameter for evaluating obesity-related renal disease. ultrasound contrast imaging; obesity-related kidney disease; renal perfusion THE GROWING EPIDEMIC OF OBESITY is a serious health and economic burden throughout the world. The consequence of obesity over time is characterized by insulin resistance, hyperglycemia, atherosclerosis, dyslipidemia, and hypertension. This cluster of risk factors referred to as metabolic syndrome occurs with 50% prevalence in patients 50-to 60-yr-old (4) and contributes to cardiovascular disease. Obesity is a major risk factor for diabetes and hypertension, which together account for ϳ70% of all cases of end-stage renal disease (6). However, there is growing evidence suggesting that obesity by itself may be an independent risk factor for the development of vascular dysfunction and renal disease (21,44,66). Obesity-related kidney disease occurs as a result of complex interactions between metabolic and hemodynamic factors and is characterized by changes of renal perfusion, vascular dysfunction, as well as albuminuria, glomerulosclerosis, and tubulointerstitial fibrosis (20,37,48,50). Alterations in blood flow within the cortex or the medulla ma...

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Section: Discussionmentioning

confidence: 64%

Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging

Declèves

Rychak

Smith

et al. 2013

American Journal of Physiology-Renal Physiology

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“…In young patients with T1D and hyperfiltration and in patients with type 2 diabetes (T2D), abnormalities in both R A and R E have been reported (20,26). Less, however, is known about the effect of exogenous ANGII on renal segmental resistance changes in humans, which may depend on a variety of clinical factors, including age (27) and weight (28). In this set of mechanistic studies, our first major observation was that, in adults with T1D, DKD resistors had similar responses in RVR to RAAS…”

Section: Discussionmentioning

confidence: 99%

Renin-angiotensin-aldosterone system activation in long-standing type 1 diabetes

et al. 2018

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“…[17][18][19] ARBs are known to dilate efferent arterioles more than afferent arterioles, and to improve glomerular hypertension because AT-1 receptors exist more abundantly in the former. 20 Reports on the nephro-protective effects of ARBs are diverse in methodology; [20][21][22][23][24][25][26][27] however, few studies have concentrated on the morphology of afferent and efferent arterioles. In this study, we examined the morphology of rat renal tissue and noted a marked improvement in glomerular lesions and tubular protein casts in the ZFR+ARB group.…”

Section: Discussionmentioning

confidence: 99%

Changes in renal vessels following the long-term administration of an angiotensin II receptor blocker in Zucker fatty rats

Nakanishi

Nagai

Piao

et al. 2011

J Renin Angiotensin Aldosterone Syst

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Introduction:The nephro-protective effects of angiotensin II receptor blockers (ARBs) are widely known; however, there are few reports of long-term effects focusing on the renal vessels. We studied afferent arteriolar changes induced by the long-term administration of an ARB. Materials and Methods: Thirty-two 6-week-old male Zucker fatty rats (ZFRs) were divided into following four groups (n = 8 in each): ZFR Group and ZFR+High Group fed a standard or high-salt diet, respectively; ZFR+ARB Group and ZFR+High+ARB Group fed a standard or high-salt diet with ARB (Olmesartan, 5 mg/kg/day), respectively. Blood pressure, proteinuria, morphological examinations and glomerular haemodynamics in vivo were studied. Results: Marked proliferative changes in the afferent arteriolar smooth muscle cells (SMCs) were frequently observed in the two groups given ARBs; in the ZFR+ARB group (77.3±10.3%) compared with the two groups without ARB (1.7%, p < 0.005; 1.2%, p < 0.0005) and 37.4±15.6% in the ZFR+High+ARB group. Proteinuria markedly decreased in the groups treated with ARBs, but the glomerular erythrocyte velocities showed no differences. Conclusions: Our findings indicate that long-term ARB administration induced unusual proliferative changes in SMCs of afferent arterioles of ZFRs. These changes could narrow arteriolar lumens and reduce intraglomerular pressure, but they could cause also irreversible damage to the arterioles.

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Preglomerular and postglomerular basal diameter changes and reactivity to angiotensin II in obese rats

Cited by 9 publications

References 37 publications

Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging

Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging

Renin-angiotensin-aldosterone system activation in long-standing type 1 diabetes

Changes in renal vessels following the long-term administration of an angiotensin II receptor blocker in Zucker fatty rats

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