Pregnancies After Premature Ovarian Failure

Consequences and treatment of ovarian failure after total body irradiation for leukaemia.

“…In six of the 14 patients reporting this it was clearly related to oestrogen deficiency (infertility and difficult intercourse), and two others felt less feminine because of a reduction in breast size. Similar comments apply to the effects of treatment on appearance: almost half (17) of the patients reported that their appearance had been adversely affected, with dry skin and dry hair the commonest cited reasons. Although naturally postmenopausal women in their early 50s often complain of these changes and a protein associated to the oestradiol receptor has been identified in epidermis, hair follicles, and sebaceous glands (which suggest that these tissues are oestrogen dependent),'2 this problem might also arise in part from the effects of generalised radiation and graft versus host disease and its treatment."…”

Spontaneous Pregnancy in a case with concurrent uterine artery embolization induced transient premature ovarian failure and Asherman syndrome: a case report

“…[1][2][3]Although pregnancy is a rare incidence among these patients, it is not unheard of. [4,10]One of the main contributors to POI is uterine artery embolisation which in many instances has been reported to have decreased ovarian reserve; it is presumed that the decrease in ovarian perfusion in consequence to embolisation in uterine artery, which provides a portion of overall blood supply to ovaries might cause this. [11][12][13]Interestingly, a transient form of ovarian failure could happen in cases of UAE, as did our patient.…”

Spontaneous pregnancy in a case with concurrent uterine artery embolization induced transient premature ovarian failure and Asherman syndrome: a case report

“…Meanwhile, premature ovarian failure (POI) is an uncommon etiology of infertility in females characterized by hypoestrogenism, elevated gonadotropin levels and amenorrhea in 1% of women under 40 years of age [ 1–3 ]. Although pregnancy is a rare incidence among these patients, it is not unheard of [ 4 , 13 ]. UAE, in many instances, has been reported to have decreased ovarian reserve; it is presumed that the decrease in ovarian perfusion as a consequence of embolization in the uterine artery, which provides a portion of the overall blood supply to ovaries might cause this [ 5 , 7 , 14 ].…”