Pregnancies in Perinatally HIV-Infected Young Women and Implications for Care and Service Programs

Millery, Mari; Vazquez, Seydi; Walther, Virginia; Humphrey, Natalie; Schlecht, Jennifer; Devanter, Nancy Van

doi:10.1016/j.jana.2011.05.008

Cited by 15 publications

(15 citation statements)

References 24 publications

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“…Current interventions for the prevention of mother-to-child transmission of HIV (PMTCT) have decreased perinatal transmission rates to 1-2% or less [4, 6], and it is estimated that fewer than 200 infants are infected annually in the US [7]. The majority of HIV-infected children now live to become adults [7, 8] and many are having children themselves [9, 10]. …”

Section: Rationale For Preconception Carementioning

confidence: 99%

Preconception and Contraceptive Care for Women Living with HIV

Hoyt¹,

Storm²,

Aaron

et al. 2012

Infectious Diseases in Obstetrics and Gynecology

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Women living with HIV have fertility desires and intentions that are similar to those of uninfected women, and with advances in treatment most women can realistically plan to have and raise children to adulthood. Although HIV may have adverse effects on fertility, recent studies suggest that antiretroviral therapy may increase or restore fertility. Data indicate the increasing numbers of women living with HIV who are becoming pregnant, and that many pregnancies are unintended and contraception is underutilized, reflecting an unmet need for preconception care (PCC). In addition to the PCC appropriate for all women of reproductive age, women living with HIV require comprehensive, specialized care that addresses their unique needs. The goals of PCC for women living with HIV are to prevent unintended pregnancy, optimize maternal health prior to pregnancy, improve maternal and fetal outcomes in pregnancy, prevent perinatal HIV transmission, and prevent HIV transmission to an HIV-uninfected sexual partner when trying to conceive. This paper discusses the rationale for preconception counseling and care in the setting of HIV and reviews current literature relevant to the content and considerations in providing PCC for women living with HIV, with a primary focus on well-resourced settings.

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Section: Rationale For Preconception Carementioning

confidence: 99%

Preconception and Contraceptive Care for Women Living with HIV

Hoyt¹,

Storm²,

Aaron

et al. 2012

Infectious Diseases in Obstetrics and Gynecology

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show abstract

“…[ 7 – 10 ] Psychosocial problems are not uncommon in this population and could be an important barrier for treatment adherence. [ 11 ] The effects of chronic HIV infection and the long-term exposure to ART of PHIV women cause concerns on the developing fetus. [ 12 , 13 ] Moreover, little is known about the risk of HIV-MTCT in PHIV women and the specific clinical management of this population.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy outcomes in perinatally HIV-infected young women in Madrid, Spain: 2000-2015

et al. 2017

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BackgroundAn increasing number of perinatally HIV-infected women (PHIV) are reaching adulthood and becoming pregnant. Most PHIV women have been exposed to a high number of antiretroviral regimens, and they may have difficulties to achieve viral suppression. Psychosocial problems are not uncommon and could be an important barrier for treatment adherence. The effects of chronic HIV infection and long-term exposure to antiretroviral treatment of PHIV women cause concerns on the developing fetus. The aims of this study were to describe the prevention of mother-to-child transmission strategies in PHIV women and the infant outcomes in the Madrid Cohort of HIV-infected mother-infant pairs.MethodsAll PHIV pregnant women registered in the Cohort that gave birth from 2000 to 2015 were included in the study.ResultsTwenty-eight pregnancies in twenty-two perinatally infected women were registered. Most women were Caucasian and heavily treatment-experienced. Nine cases (32.1%) were at high risk of HIV mother-to-child transmission. Maternal HIV-1 viral load was detectable close to delivery in four women (14.3%). The management of these cases was described, and the treatment strategies were discussed. None of the newborns acquired HIV infection. Eight infants (28.6%) were small for gestational age.ConclusionsThis study included a large series of pregnancies among PHIV women attended according to a youth-centered care model. The challenges in the management of this population by health-care providers were described. Specific strategies to minimize perinatal transmission risks should be addressed in future collaborative studies.

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“…In 32 live births from a cohort of pregnant PHIV adolescents enrolled in the Pediatrics AIDS Clinical Trials protocol 219, the rate of vertical transmission of HIV infection was calculated to be 3.3 percent [44]. Other study sites reported comparable low rates of vertical transmission of HIV: no cases of vertical transmission of HIV in 19 infants in New York and 6 infants in Puerto Rico [45,46].…”

Section: Similar Risk Of Mother-to-child-transmission Of Hivmentioning

confidence: 99%

Growing Up with Perinatally-Acquired HIV Infection: Psychosocial, Behavioral, and Reproductive Issues

Dola¹

2015

ACRS

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Background There are an estimated 3.2 million children living with Human Immunodeficiency Virus (HIV) globally [1]. A majority of these children acquire HIV from their mother during pregnancy, birth, or breastfeeding [2]. With the success of newer HIV drug therapies, the number of children surviving into adolescence and adulthood has increased drastically in the last decade, especially in resource-rich developed countries [1]. In the United States, the population of children with Perinatally-acquired HIV (PHIV) consists of approximately 8,500 patients [3]. As these children enter adolescence and adulthood, they are encountering a number of different

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Pregnancies in Perinatally HIV-Infected Young Women and Implications for Care and Service Programs

Cited by 15 publications

References 24 publications

Preconception and Contraceptive Care for Women Living with HIV

Preconception and Contraceptive Care for Women Living with HIV

Pregnancy outcomes in perinatally HIV-infected young women in Madrid, Spain: 2000-2015

Growing Up with Perinatally-Acquired HIV Infection: Psychosocial, Behavioral, and Reproductive Issues

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