Pregnancy after age 50: Application of oocyte donation to women after natural menopause

Sauer, Mark V.; Paulson, Richard J.; Ra, Lobo

doi:10.1016/0020-7292(93)90255-u

Cited by 35 publications

(43 citation statements)

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“…1 Successful pregnancies are now being achieved with oocyte donations in women over age 50 and beyond natural menopause. 2 Recently, one such birth to a 63-year-old woman was publicized widely. 3 Some of the most devastating adverse outcomes in older pregnant women are anomalies associated with chromosomal aberrations, especially aneuploidies, which occur in about one in 50 births to women at age 40.…”

mentioning

confidence: 99%

Maternal age and malformations in singleton births

Hollier

Leveno²,

Kelly

et al. 2000

Obstetrics & Gynecology

153

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Objective: To examine the effect of maternal age on incidence of nonchromosomal fetal malformations.Methods: Malformations detected at birth or in the newborn nursery were catalogued prospectively for 102,728 pregnancies, including abortions, stillbirths, and live births, from January 1, 1988 to December 31, 1994. Maternal age was divided into seven epochs. Relative risks (RRs) were used to compare demographic variables and specific malformations. The Mantel-Haenszel 2 statistic was used to compare agespecific anomalies. Multiple logistic regression analysis was used to adjust for parity.Results: Abnormal karyotypes were significantly more frequent in older women. After excluding infants with chromosomal abnormalities, the incidence of structurally malformed infants also was increased significantly and progressively in women 25 years of age or older. The additional age-related risk of nonchromosomal malformations was approximately 1% in women 35 years of age or older. The odds ratio for cardiac defects was 3.95 in infants of women 40 years of age or older (95% CI 1.70, 9.17) compared with women aged 20 -24 years. The risks of clubfoot and diaphragmatic hernia also increased as maternal age increased. During the past decade, the proportion of women in the United States who gave birth after age 35 increased significantly. In 1996, there were approximately 399,510 births to women aged 35-39 years, 71,804 to women aged 40 -44, and over 3000 to women aged 45-49 years. Conclusion1 Successful pregnancies are now being achieved with oocyte donations in women over age 50 and beyond natural menopause.2 Recently, one such birth to a 63-year-old woman was publicized widely. 3Some of the most devastating adverse outcomes in older pregnant women are anomalies associated with chromosomal aberrations, especially aneuploidies, which occur in about one in 50 births to women at age 40. 4 Increased aneuploidy rates are unequivocally related to advanced maternal age, but the effect of increased age on other congenital malformations is less clear. Each year the National Center for Health Statistics and the Centers for Disease Control and Prevention publish natality statistics of the entire United States, which include information on congenital malformations from birth certificates. Those agencies have cited significantly increased rates of fetal cardiac malformations and chromosomal anomalies with advanced maternal age.5 However, such reports have numerous shortcomings. For example, because individual congenital malformations have such low incidences, epidemiologic studies necessarily include large numbers of pregnancies. To accomplish that, information is gathered from indirect sources such as birth certificates, which often are incomplete and subject to ascertainment biases. Those reports and most similar investigations do not include information on malformations in stillborn fetuses or late abortions.The demographic make-up of Parkland Hospital provides a unique opportunity to study congenital malformations. The large obstetric po...

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confidence: 99%

Maternal age and malformations in singleton births

Hollier

Leveno²,

Kelly

et al. 2000

Obstetrics & Gynecology

153

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“…Women over the age of 50 who used their own oocytes for IVF had signifi cantly lower pregnancy rates than women who used oocytes donated by younger women. In fact, older women receiving young donor oocytes experienced pregnancy rates similar to those of young women undergoing IVF [ 6 ]. This suggests that oocyte quality and not endometrial receptivity is the main cause for the agerelated decline in fertility.…”

Section: Overview and Introductionmentioning

confidence: 80%

Insights into Mechanisms Causing the Maternal Age-Induced Decrease in Oocyte Quality

Boudoures

Moley

2015

Biennial Review of Infertility

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“…However, how these growth factors are linked to sex hormones has not been clearly described. The interesting phenomenon about the endometrium is that whereas the ovaries cease to operate permanently after menopause, the endometrium retains the capacity to undergo proliferation and growth upon stimulation (Sauer et al, 1993;Liverro et al, 1999). This is a unique feature that is present in human species.…”

Section: Ovaries and The Biology Of Menopause: The Role For Inhibin Imentioning

confidence: 96%

“…In other mammals it is the uterus that fails to support nidation; production of oocytes continues well into old age (Finn, 2001). Postmenopausal endometrium has been shown to support implantation and growth of pregnancy to term (Sauer, 1993;Finn, 2001).…”

Section: Ovaries and The Biology Of Menopause: The Role For Inhibin Imentioning

confidence: 99%

Morpho-physiological features associated with menopause: recent knowledge and areas for future work

Mwampagatwa

Mwashambwa

Gesase

2013

Tanzania J Hlth Res

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Abstract:Menopause is the permanent cessation of menstruation resulting from loss of ovarian follicular activity which happens as a result of depletion of primary follicles which is basically an aging effect. Depletion of ovarian follicles is reflected as declined production of oestradiol which is currently known to be central to the morphologic and physiological changes that happen during the climacteric, menopause and post menopause periods. The cessation of oestradiol production is much more pronounced in tissues with oestrogen receptors such as bones, brain, blood vessels, central nervous system and the skin. But generally little is known on the subject and in particular the bioactive substances involved in the process such that there are some symptoms that menopause women experience which not only defy clinicians but also challenge the management of the condition. This article is presented to shade light to what is currently known, what is not known and stimulate future research which may reveal more understanding and advance our knowledge on management of women throughout the climacteric and menopausal periods.

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Pregnancy after age 50: Application of oocyte donation to women after natural menopause

Cited by 35 publications

References 0 publications

Maternal age and malformations in singleton births

Maternal age and malformations in singleton births

Insights into Mechanisms Causing the Maternal Age-Induced Decrease in Oocyte Quality

Morpho-physiological features associated with menopause: recent knowledge and areas for future work

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