Pregnancy after liver transplantation

Ramirez, Carlo B.; Doria, Cataldo

doi:10.1016/j.bpobgyn.2014.07.022

Cited by 26 publications

(21 citation statements)

References 27 publications

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“…Successful LT, however, can restore ovulation and childbearing potential within 10 months following LT . There is a consensus among both transplant care providers and obstetricians that pregnancy should be planned at least 12 months after LT with stable allograft function for favorable pregnancy outcomes . Moreover, unplanned pregnancy in recipients using mycophenolate mofetil should be avoided due to its potential teratogenicity .…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in liver transplant recipients: A 15‐year single‐center experience

Kanzaki

Kondoh

Kawasaki

et al. 2016

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in liver transplant recipients: A 15‐year single‐center experience

Kanzaki

Kondoh

Kawasaki

et al. 2016

J of Obstet and Gynaecol

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“…Patients pregnant after LT are at risk of a preterm birth . Therefore, they may benefit from the standard intramuscular doses of steroids to accelerate fetal lung development between 24 and 34 weeks.…”

Section: Delivery and Postpartum Carementioning

confidence: 99%

“…It is estimated that 8% of liver transplantation (LT) recipients are women of reproductive age, and another 5% are girls, most of whom will live until reproductive age and will consider the possibility of pregnancy . The number of patients who are undergoing solid organ transplants is increasing as well as their quality of life (QOL) and chance for pregnancy.…”

mentioning

confidence: 99%

Pregnancy in the liver transplant recipient

et al. 2016

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During gestation, the woman's body undergoes various changes, and the line between physiology and pathology is very thin even in healthy women. Today, many of the liver transplant recipients are young women, who at one point in their lives may consider the possibility of pregnancy. Clinicians have to counsel them about the time of conception, the risk of miscarriage, the deterioration of the mother's health status, and the risk of birth defects. This review, based on our 20 years of clinical experience and up-to-date literature, provides comprehensive guidelines on pregnancy management in liver transplant recipients. Pregnancy in liver transplant recipients is possible but never physiological. Proper management and pharmacotherapy lowers the incidence of complications and birth defects. Critical factors for perinatal success include stable graft function before pregnancy, proper preparation for pregnancy, and cautious observation during its course. Liver Transplantation 22 1408-1417 2016 AASLD.

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“…Mycophenolate mofetil is not used because of its teratogenicity. The use of other immunosuppressive drugs results in a similar malformation rate as in the general population . Accordingly, pregnancy after LT and during immunosuppressive medication is possible but associated with increased risk of obstetrical complications including preeclampsia (22%), fetal growth restriction and preterm birth (39%) .…”

Section: Introductionmentioning

confidence: 99%