Pregnancy and birth outcomes in a Danish nationwide cohort of women with autoimmune hepatitis and matched population controls

Grønbæk, Lisbet; Vilstrup, Hendrik; Jepsen, Peter

doi:10.1111/apt.14925

Cited by 34 publications

(35 citation statements)

References 37 publications

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“…Another cohort study from Denmark also found no association between AIH and birth outcomes and congenital malformations, while suggesting an association with preterm birth and small-for-gestational age babies. 36 Westbrook et al reported the outcomes of 81 pregnancies in 53 women with AIH, with 41% of pregnancies occurring in cirrhotics. 37 The live birth rate was 73% (59/ 81), and was significantly lower in cirrhotic mothers (P= 0.02).…”

Section: Tablementioning

confidence: 99%

Liver disease in pregnancy

Sasamori¹,

Tanaka

Ayabe³

2020

Hepatology Research

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Development of liver diseases during pregnancy is not uncommon. They are caused by either a disorder that is unique to pregnancy or an acute or chronic liver disease that already exists or coincidentally develops as a comorbidity of pregnancy. Liver diseases unique to pregnancy include hyperemesis gravidarum; hypertensive disorders of pregnancy, such as pre‐eclampsia/eclampsia; hemolysis, elevated liver enzymes, and low platelet count syndrome; intrahepatic cholestasis of pregnancy; and acute fatty liver of pregnancy. Chronic liver diseases that affect pregnancy, or are affected by pregnancy, mainly include autoimmune liver diseases and non‐alcoholic fatty liver disease. Prompt diagnosis and management of liver diseases in pregnancy, while very challenging, is extremely important, as they might cause adverse maternal and fetal outcomes. Therefore, a multidisciplinary, collaborative approach involving both hepatologists and obstetricians is required. In this review article, the up‐to‐date epidemiology, etiology, clinical features, and outcomes of liver diseases in pregnancy are discussed, to promote a deeper understanding among physicians, and subsequently improved outcomes.

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Section: Tablementioning

confidence: 99%

Liver disease in pregnancy

Sasamori¹,

Tanaka

Ayabe³

2020

Hepatology Research

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“…The enormous strength is the size of the data pool reducing bias such as referral bias inherent in data from referral centres, or age bias by only including data from paediatric or adult institutions. In this respect, the Danish registry is one of the world leaders and has already taught us many important lessons . The present two studies fall into this category.…”

mentioning

confidence: 55%

Autoimmune hepatitis: Is the autoimmunity in the family?

Sebode

Lohse

2018

Liver International

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“…In the absence of cirrhosis, women with AIH do not have reduced fertility. (165) Serum aminotransferase levels tend to improve during pregnancy, with spontaneous remissions reported. (166)(167)(168) Flares can occur at any time during and after pregnancy, with rare cases of urgent LT reported.…”

Section: Autoimmune Hepatitismentioning

confidence: 99%

“…Azathioprine has been associated with congenital malformations in pregnant mice, (177) but an increased risk of teratogenicity is not established in humans. (165,170,173) (Table 6) Thus, thiopurines may be used in pregnancy. Small amounts of thiopurine metabolite can be detected in breast milk, (178) but this has not been associated with significant adverse infant outcomes.…”

Section: Accepted Articlementioning

confidence: 99%