Pregnancy and breast cancer

Sasidharan, Rita; Harvey, Vernon

doi:10.1258/om.2010.090066

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…Breast cancer is usually diagnosed with metastasis in pregnant women with advanced age,9 and similar was the case with this 44-year-old patient in whom the cancer had spread to the lungs and liver. Estrogen and progesterone receptors are frequently negative in PABC,18 as evidenced in this patient who was estrogen receptor negative and weak progesterone positive.…”

Section: Discussionmentioning

confidence: 59%

<p>Nanosomal docetaxel lipid suspension based chemotherapy in a pregnant MBC patient – a case report</p>

Ramaswamy

Joshi

Khan

et al. 2019

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The current report presents a case of a pregnant woman with breast cancer metastasized to liver and lungs. The standard of care for breast cancer in pregnancy is anthracycline/taxane-based chemotherapy regimens. Docetaxel has shown a favorable toxicity profile during the second and third trimesters of pregnancy. A novel nanosomal docetaxel lipid suspension (NDLS) (DoceAqualip), with a proven efficacy and tolerability profile, has been approved in India for the treatment of advanced solid tumors since 2013. We present here a case of a pregnant woman with metastatic breast cancer managed with NDLS based TAC regimen showing a partial response after six cycles. The patient delivered a healthy male child with normal Apgar score and weight at the 32nd week of gestation.

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Section: Discussionmentioning

confidence: 59%

<p>Nanosomal docetaxel lipid suspension based chemotherapy in a pregnant MBC patient – a case report</p>

Ramaswamy

Joshi

Khan

et al. 2019

OTT

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“…Surgery may be carried out in any trimester with little risk to the foetus. Breast reconstruction should be postponed until after delivery as well as post-mastectomy and post-lumpectomy irradiation [32][33][34][35][36]. The recommendations regarding SLNB are discussed in the section on diagnosis in this article.…”

Section: Breast Cancermentioning

confidence: 99%

Multidisciplinary consensus on cancer management during pregnancy

et al. 2020

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Cancer during pregnancy is a challenge for multi- and interdisciplinary collaboration due to the diagnostic, prognostic and therapeutic implications, the need for an integrated harmonization of medical action for the pregnant patient and the embryo or foetus and the characteristics of each gestational period, which will determine the protocol to be proposed and its limitations. For this reason, a group of experts appointed by participating scientific societies, which includes the Spanish Society of Medical Oncology (Sociedad Española de Oncología Médica—SEOM), the Spanish Association of Surgeons (Asociación Española de Cirujanos—AEC), the Spanish Society of Gynaecology and Obstetrics (Sociedad Española de Ginecología y Obstetricia—SEGO), the Spanish Society of Nuclear Medicine and Molecular Imaging (Sociedad Española de Medicina Nuclear e Imagen Molecular—SEMNIM), the Spanish Society of Oncological Radiotherapy (Sociedad Española de Oncología Radioterápica—SEOR) and the Spanish Society of Medical Radiology (Sociedad Española de Radiología Médica—SERAM), have worked together to establish consensus recommendations that allow the harmonization of management and ultimately the optimization of the healthcare of pregnant patients with cancer. When cancer is detected in a pregnant woman, the week of gestation in which the diagnosis is made must be considered, as well as the characteristics of the tumour. It is strongly recommended that a multidisciplinary team assesses the situation and guides the patient and her family during the informing, diagnosis and treatment process. Likewise, the foetus should be monitored and managed by specialized obstetricians who are part of a multidisciplinary cancer committee.

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“…However, Tc-99m injection at a dose of 12.1-18.5 mBq is safe for the fetus and the obstetric outcome. Adjuvant chemotherapy can be initiated after 16 weeks’ gestation, following the completion of organogenesis, while radiation is delayed until after delivery, despite evidence that radiation of the axilla or chest could be safe after the 1 st trimester ( 8 , 9 ). External beam radiation can be used whenever the fetus can be exposed to secondary radiation due to head leakage, scatter from the machine, and scatter produced inside the patient ( 10 ).…”

Section: Breast Cancer In Pregnancymentioning

confidence: 99%

Current management of gynecologic cancer in pregnancy

Iavazzo¹,

Minis²,

Gkegkes³

2018

J Turkish German Gynecol Assoc

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Cancer during pregnancy is a particularly challenging complication. The incidence has increased in recent years due to childbearing at advanced maternal ages due to career choices and/or the development of reproductive technology. Approximately two thirds of cancer cases during pregnancy comprise invasive cervical cancers and breast cancer. Cancer during gestation is characterized by a need for specialized treatment due to major changes in the hormonal profile (estrogen-progesterone), metabolism (enhancement of anabolism), hemodynamic changes (hyperdynamic circulation), immunologic changes (cell-mediated and humoral immunity), and increased angiogenesis (increased blood flow towards the uterus). Moreover, the management of such patients is based on the trimester of pregnancy, type and stage of cancer, and informed consent of the mother based on her wishes. The optimal treatment of cancer during pregnancy remains elusive because there are limited data from retrospective studies with small samples. As a result, it is crucial that data regarding survival of the women and long-term follow-up of the children from different cancer centers and registries are shared. This need is dictated by the fact that the incidence of cancer during pregnancy will continue to rise as child-bearing age continues to increase.

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Pregnancy and breast cancer

Cited by 5 publications

References 37 publications

<p>Nanosomal docetaxel lipid suspension based chemotherapy in a pregnant MBC patient – a case report</p>

<p>Nanosomal docetaxel lipid suspension based chemotherapy in a pregnant MBC patient – a case report</p>

Multidisciplinary consensus on cancer management during pregnancy

Current management of gynecologic cancer in pregnancy

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