Pregnancy and Delivery in a Patient With Metastatic Embryonal Sarcoma of the Liver

Shufaro, Yoel; Uzieli, Beatrice; Pappo, Orit; Abramov, Yoram

doi:10.1097/00006250-200205001-00032

Cited by 4 publications

(9 citation statements)

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“…At the time of last follow‐up examination 11 of 14 of these patients revealed no evidence of disease. Two of 14 patients were alive with disease15, 16 (duration, 29 months and 60 months, respectively), and 1 patient was alive with unknown disease status7 (duration, 204 months).…”

Section: Resultsmentioning

confidence: 99%

Undifferentiated embryonal sarcoma of the liver in adults

Lenze

Birkfellner

Lenz

et al. 2008

Cancer

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BACKGROUND Undifferentiated embryonal sarcoma of the liver (UESL), a rare tumor that predominantly affects children, generally has been considered an aggressive neoplasm with an unfavorable prognosis. More recent reports have indicated that modern multimodal treatment and supportive care improve the survival of children with UESL. Data regarding the treatment and survival of adults have not been reviewed comprehensively, and only a few adult patients with UESL have been reported in the literature. METHODS The authors analyzed demographics, treatment, and actuarial survival of all reported cases of UESL in patients aged ≥15 years (n = 67 patients). In addition, 1 case is presented of a patient with UESL who was treated successfully at the authors' institution. RESULTS The median survival of all patients with UESL who were analyzed was 29 months. Patients who underwent complete tumor resection followed by adjuvant chemotherapy survived over a median follow‐up of 28.5 months and had significantly better survival compared with patients who underwent surgical treatment alone. Patients who underwent an incomplete tumor resection had a tendency toward poorer outcomes. CONCLUSIONS To the authors' knowledge, this is the first report to demonstrate a significant effect on survival for adjuvant chemotherapy after complete surgical resection of UESL in adults. The role of neoadjuvant chemotherapy was not evaluated in this study. In the case study presented herein, combined therapy with surgery and chemotherapy led to a complete, sustained remission that has lasted for >6 years to date. Cancer 2008. © 2008 American Cancer Society.

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Section: Resultsmentioning

confidence: 99%

Undifferentiated embryonal sarcoma of the liver in adults

Lenze

Birkfellner

Lenz

et al. 2008

Cancer

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“…Nevertheless, recent evidence has shown that long-term survival is possible after complete surgical resection with or without postoperative chemotherapy: 17 patients were reported as alive without disease for an average of 39 months, while 5 patients were reported as alive and free of disease for more than 5 years. 14,25,27,31 The risk of recurrence after surgery is relatively high for the fi rst 2 years; 14,16,20,23,25,27,31,[36][37][38][39][40][41] positive resection margins and spontaneous or iatrogenic rupture of UES were associated with early recurrence and death. Most of the patients with tumor recurrence survived for less than 1 year, and recurrence in the remnant liver was the most common reason for failure after surgery.…”

Section: Treatment and Outcomesmentioning

confidence: 99%

Undifferentiated embryonal sarcoma of the liver: case report and literature survey

Pachera

Nishio

Takahashi

et al. 2008

J Hepatobiliary Pancreat Surg

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Undifferentiated embryonal sarcoma (UES) of the liver was first identified as an independent clinicopathologic type of sarcoma in 1978. It is an uncommon hepatic tumor, of mesenchymal origin, usually observed in children, and cases in adults are rare: to our best knowledge, reports of only 51 cases have been published in the past 50 years. We present a case of UES of the liver in a previously healthy 22 year-old woman, admitted to our hospital due to a palpable mass in the right upper abdomen. On admission, laboratory studies showed mildly elevated aspartate aminotransferase, alkaline phosphatase, and gamma-GPT. Hepatitis and tumor markers were negative. Ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) showed a large mass involving the right lobe and the medial segment of the liver, with compression of the bile duct. Right trisectionectomy with bile duct resection and reconstruction was performed. Microscopically, the tumor was composed of pleomorphic spindle cells in a myxoid stroma with focal staining of S-100 by immunohistochemistry. The histologic diagnosis was UES. Adjuvant therapy with vincristine, actinomycin-D, and cyclophosphamide was performed, and at 14 months of follow-up, the patient is alive without any evidence of recurrence. The clinical and histopathological features, as well as the therapeutic choices for adult UES, are described for this patient and in the literature of the past 50 years.

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“…4 The chemotherapeutic drugs used are vincristine, actinomycin D, doxorubicin, cyclophosphamide, tiropramide, and cisplatin. 2,4,10 UESL in pregnant women is very rare, and all these few case reports appear to have different characteristics. There were two cases in which patients underwent hepatectomy and had a relapse and metastasis of UESL prior to being pregnant.…”

Section: Discussionmentioning

confidence: 99%