Pregnancy and Hemostasis: From Physiology to Pathological States

Tlamcani, Imane; El Mouh, Nadia; El Amrani, Kawthar; Amrani Hassani, Moncef

doi:10.33309/2639-8354.010108

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…Pregnancy provokes a decrease in tissue plasminogen activator (tPA), an increase in plasminogen activator inhibitor (PAI)-1 activity and the synthesis of PAI-2 by the placenta. Conclusively, there is the development of hypofibrinolysis [ 5 ]. The levels of novel coagulation markers plasmin-α2 plasmin inhibitor complex (PIC), thrombin–antithrombin complex (TAT), thrombomodulin (TM) and tissue plasminogen activator/plasminogen activator inhibitor compound (tPAI-C) in pregnant patients increase significantly throughout the pregnancy and gradually return to normal ranges after delivery.…”

Section: Introductionmentioning

confidence: 99%

Evaluating Thromboprophylaxis Strategies for High-Risk Pregnancy: A Current Perspective

Stančiaková,

Brisudová,

Škorňová

et al. 2024

Pharmaceuticals

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Venous thromboembolism (VTE) represents one of the leading causes of death during pregnancy. The greatest risk for it is the presence of medical or family history of VTE, stillbirth, cesarean section and selected thrombophilia. Appropriate thromboprophylaxis has the potential to decrease the risk of VTE in at-risk pregnant patients by 60–70%. Based on this, the authors reviewed the PubMed, Web of Science and Scopus databases to identify the possibilities of thromboprophylaxis in pregnant patients with a high risk of VTE. Moreover, they summarized its management in specific situations, such as cesarean delivery or neuraxial blockade. Currently, low-molecular-weight heparins (LMWH) are the preferred drugs for anticoagulant thromboprophylaxis in the course of pregnancy and postpartum due to easy administration and a lower rate of adverse events.

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Section: Introductionmentioning

confidence: 99%