Pregnancy and Interstitial Cystitis/Painful Bladder Syndrome

Erickson, Deborah; Propert, Kathleen J.

doi:10.1016/j.ucl.2006.10.006

Cited by 16 publications

(19 citation statements)

References 47 publications

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“…Post hoc tests revealed significant differences in the UBD-evoked EMG responses at intensities of 40, 50, and 60 mm Hg (Figure 1). These results suggest the period of lactation is a hypoalgesic state in this animal model of bladder nociception consistent with clinical observations related to bladder pain 14,18…”

Section: Resultssupporting

confidence: 89%

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Effects of Oxytocin and Prolactin on Stress-Induced Bladder Hypersensitivity in Female Rats

Black

Ness

Robbins

2009

The Journal of Pain

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Anecdotal evidence suggests that chronic bladder pain improves while breastfeeding. The present study sought to identify potential mechanisms for such a phenomenon by investigating the effects of the lactogenic hormones prolactin (PL) and oxytocin (OXY) in a rat model of bladder nociception. Lactating rats were less sensitive to urinary bladder distension (UBD) than controls. In investigating potential antinociceptive and anxiolytic roles for these hormones, we found exposure to a footshock paradigm (STRESS groups) produced bladder hypersensitivity in saline-treated rats, manifested as significantly higher electromyographical (EMG) responses to UBD, compared to rats exposed to a non-footshock paradigm (SHAM groups). This hypersensitivity was attenuated by the intraperitoneal administration of OXY prior to footshock in the STRESS-OXY group. The administration of PL augmented EMG responses in the SHAM-PL group but had no effect on the responses of the STRESS-PL group. In the absence of behavioral pretreatment, OXY attenuated UBD-evoked responses while PL had no effect. Moreover, OXY-treated rats spent more time in the open arm of an elevated plus maze compared to saline-treated rats suggesting anxiolysis. These studies suggest the potential for systemic OXY, but not PL, as an analgesic and anxiolytic treatment for painful bladder disorders such as interstitial cystitis.

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Section: Resultssupporting

confidence: 89%

“…Anecdotal evidence suggests patients with the painful bladder disorder interstitial cystitis can experience a significant attenuation of their symptoms while breastfeeding 14. This observation led us to hypothesize that hormones involved in postpartum lactation, namely oxytocin (OXY) and prolactin (PL), would attenuate bladder nociception.…”

Section: Introductionmentioning

confidence: 99%

Effects of Oxytocin and Prolactin on Stress-Induced Bladder Hypersensitivity in Female Rats

Black

Ness

Robbins

2009

The Journal of Pain

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“…The high expression of hCGb in BPS/IC is surprising, because this seems to contradict the observation of symptom improvement during pregnancy [8,9]. However, our methods did not discern between distinct glycosylation 1.952 9 10 -8 ± 2.66 9 10 -8 1.644 9 10 -7 ± 3.441 9 10 -7 hCGb7 5.333 9 10 -6 ± 6.47 9 10 -6 1.429 9 10 -5 ± 1.637 9 10 -5 Immunofluorescence values for beta-1 and beta-2 expression are given as mean (95% CI).…”

Section: Discussionmentioning

confidence: 92%

“…Especially interesting is the fact that hCGb expression is enhanced during middle secretion phase and late secretion phase [6,7]. The clinical observation that BPS/IC symptoms often improve significantly with onset of gravidity [8,9] suggests pregnancy-induced elevated hCG levels might have an effect on urothelium as well ( Fig. 1) [10,11].…”

Section: Introductionmentioning

confidence: 99%

Enhanced urothelial expression of human chorionic gonadotropin beta (hCGβ) in bladder pain syndrome/interstitial cystitis (BPS/IC)

Schwalenberg

Stolzenburg

et al. 2011

World J Urol

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The constitutive expression of hCG and LHR speaks in favour for a functional signalling in urothelial cells without any association with either pregnancy or tumour. We show for the first time that hCGβ is upregulated in BPS/IC urothelium and that hCGβ7 is the dominant splice variant in those cells. Our findings imply a major role of hCG for urothelial integrity and a disturbance of hCG signalling in case of BPS/IC. We conclude that hCG could gain therapeutical relevance in the future.

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“…There is little published information about the changes in symptoms that may occur during pregnancy. 100 The IC Association conducted a patient survey about symptoms and pregnancy in 1989, where patients who described their symptoms as 'mild' experienced worsening symptoms during pregnancy, which persisted up to 6 months after delivery. In contrast, patients who described their symptoms as 'severe' had a significant improvement in symptoms during the second trimester, which lasted up to 6 months after delivery or for the duration of breastfeeding.…”

mentioning

confidence: 99%

Management of Bladder Pain Syndrome

2016

BJOG

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Pregnancy and Interstitial Cystitis/Painful Bladder Syndrome

Cited by 16 publications

References 47 publications

Effects of Oxytocin and Prolactin on Stress-Induced Bladder Hypersensitivity in Female Rats

Effects of Oxytocin and Prolactin on Stress-Induced Bladder Hypersensitivity in Female Rats

Enhanced urothelial expression of human chorionic gonadotropin beta (hCGβ) in bladder pain syndrome/interstitial cystitis (BPS/IC)

Management of Bladder Pain Syndrome

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