Pregnancy and long-term cardiovascular outcomes in women with congenitally corrected transposition of the great arteries

Abstract

Successful pregnancy can be achieved by most women with ccTGA. The most common cardiovascular complications are supraventricular arrhythmias but pregnancy does not seem to impair right ventricular function in the long term. Nevertheless, preconception counseling and tertiary care during pregnancy for women with ccTGA are recommended.

Management of Pregnancy in Patients With Complex Congenital Heart Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association

“…163,208,209 Other studies suggest, however, that RV function is not changed by pregnancy. 210 Because data are derived from small case series, the data are controversial, and as with many concerns about pregnancy and CHD, it is difficult to determine whether the decline in systemic RV function is simply a function of time or truly is made worse by preg-nancy. 168 Regardless of cause, heart failure can complicate both the pregnancy and the years after pregnancy.…”

Pregnancy and Adult Congenital Heart Disease

“…29 Supraventricular arrhythmias appear to be common, but significant decline in systemic ventricular function does not appear to occur in the short term related to pregnancy. 30 Successful pregnancy can be achieved in most women with TGA; however, the rate of fetal loss and maternal cardiovascular morbidity is increased. 31 …”

The long-term outcomes of physiologic repair for ccTGA (congenitally corrected transposition of the great arteries)

“…After implantation of a mechanical valve, anticoagulant therapy, primarily using warfarin, is indispensable, and medication and dose level adjustment are sometimes difficult in children. Furthermore, there are many females with ccTGA, requiring surgeons to consider the possibility of pregnancy and delivery [13,14]. The use of a biological valve is beneficial in terms of the need for anticoagulant therapy, but the durability of biological valves is poor compared to the mechanical type, necessitating reoperation.…”