Pregnancy and neonatal outcomes following letrozole use in frozen–thawed single embryo transfer cycles

Tatsumi, Takayuki; Jwa, Seung Chik; Kuwahara, Akira; Irahara, Minoru; Kubota, Toshiro; Saito, Hidekazu

doi:10.1093/humrep/dex066

Cited by 65 publications

(67 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This method is particularly effective when the same patients are included multiple times in the total cohort, as for IUI or ART. We previously analyzed online Japanese ART data adjusting for correlations within clinics using this method . The reason why we selected IUI data to detect any effects of advanced paternal age because ART could mask sperm impairments such as fertility disorders.…”

Section: Introductionmentioning

confidence: 99%

“…We previously analyzed online Japanese ART data adjusting for correlations within clinics using this method. 8 The reason why we selected IUI data to detect any effects of advanced paternal age because ART could mask sperm impairments such as fertility disorders. This study aimed to evaluate the relationships between paternal age and pregnancy outcomes and sperm parameters following IUI, after adjusting for multiple outcomes in the same patients.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Advanced paternal age alone does not adversely affect pregnancy or live‐birth rates or sperm parameters following intrauterine insemination

Tatsumi

Ishida

Tatsumi

et al. 2018

Reprod Medicine & Biology

View full text Add to dashboard Cite

PurposeThis study aimed to evaluate the effect of advanced paternal age on pregnancy outcomes and sperm parameters following intrauterine insemination (IUI). We used IUI data rather than assisted reproductive technology data, which might mask the effects of sperm impairments.MethodsWe retrospectively analyzed 1576 IUI cycles in women under 40 years old between April 2012 and May 2016 at the National Center for Child Health and Development in Japan. The main outcomes were clinical pregnancy and live birth.ResultsThe mean male age was significantly lower in cycles that resulted in pregnancy compared with those without pregnancy (38.0 vs 39.1 years; P < 0.001), with a similar trend for live‐birth cycles. However, there was no relationship between advanced paternal age and pregnancy outcomes after adjusting for confounding factors and correlations within patients using generalized estimating equations, and the age of the female partner was the only factor affecting pregnancy rate. Furthermore, advanced paternal age had no effect on sperm parameters.ConclusionsAdvanced paternal age alone does not adversely affect pregnancy or live‐birth rates or sperm parameters following IUI.

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Advanced paternal age alone does not adversely affect pregnancy or live‐birth rates or sperm parameters following intrauterine insemination

Tatsumi

Ishida

Tatsumi

et al. 2018

Reprod Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…A possible reason for this could be the significant inconsistencies in basic characteristics between groups, such as younger patient age, greater possibility of blastocyst transfer, and different luteal-phase support methods in the letrozole group. Excluding the study of Tatsumi et al [27] did not lead to a reversal of the outcomes, demonstrating the stability of the results. The study by Li et al [29] accounted for the heterogeneity in the comparison of EMT between letrozole and NC, with opposite outcomes observed after excluding this study, suggesting that this result is instable.…”

Section: Discussionmentioning

confidence: 67%

“…BDR was not estimated as no birth defect was observed in either arm of the study. In the other 5 studies, HMG was not used in the letrozole arm [21,22,25,27,29]. When letrozole alone was compared with NC, the OR did not differ significantly for CPR (OR 1.30, 95 % CI: 0.68-2.52) (▶ Fig.…”

Section: Results Of Meta-analysismentioning

confidence: 99%

“…As significant heterogeneity was observed in this study, we performed a sensitivity analysis for comparisons of more than 3 studies (▶ Table 2). The heterogeneity of the studies comparing the CPR and LBR with letrozole with those with NC was noted to be significantly decreased after the study by Tatsumi et al [27] was omitted, with I 2 decreasing from 97 % to 52 % and from 97 % to 63 %, respectively. Similarly, when the CPR and LBR with letrozole were compared with CPR and LBR with AC, exclusion of the study by Tatsumi et al significantly decreased the heterogeneity of the studies, with I 2 decreasing from 97 % to 59 % and from 98 % to 51 %, respectively.…”

Section: Sensitivity Analysismentioning

confidence: 98%

See 1 more Smart Citation

Pregnancy Outcomes Following Letrozole Use in Frozen-thawed Embryo Transfer Cycles: A Systematic Review and Meta-analysis

Chen

Shen

et al. 2020

Geburtshilfe Frauenheilkd

View full text Add to dashboard Cite

While widely used for ovulation induction in assisted reproductive technology, the clinical efficacy of letrozole for endometrial preparation prior to frozen-thawed embryo transfer (FET) cycles remains yet to be elucidated. We performed a meta-analysis to compare pregnancy outcomes after letrozole use with those of other endometrial preparation protocols in patients undergoing FET. PubMed, Scopus, Embase and the Cochrane Library were searched for eligible studies. Clinical pregnancy rate (CPR), live birth rate (LBR) and birth defect rate (BDR) were analysed using odds ratio (OR) and 95% confidence interval (CI). A total of 10 studies representing 75 968 FET cycles were included. Comparable CPR and LBR were observed when comparing letrozole administration with natural cycle (OR 1.24, 95% CI: 0.69 – 2.24; OR 1.18, 95% CI: 0.60 – 2.32), artificial cycle (OR 1.46, 95% CI: 0.87 – 2.44; OR 1.39, 95% CI: 0.77 – 2.52), and artificial cycle with gonadotropin-releasing hormone agonist suppression (OR 1.11, 95% CI: 0.78 – 1.59; OR 1.18, 95% CI: 0.82 – 1.68). Pooled results of the limited studies comparing letrozole with human menopausal gonadotropin demonstrated a similar CPR between groups (OR 1.46, 95% CI: 0.29 – 7.21, two studies), but the letrozole group had a statistically lower LBR (OR 0.67, 95% CI: 0.52 – 0.86, one study). No increased BDR was observed in the letrozole group compared to natural cycles or artificial cycles (OR 0.98, 95% CI: 0.60 – 1.61; OR 1.39, 95% CI; 0.84 – 2.28). This pooled analysis supports the use of letrozole as an efficacious and safe alternative to mainstream regimens for endometrial preparation in FET cycles.

show abstract

Androgens for Improving Ovarian Response to Stimulation

Yakın

2020

Textbook of Assisted Reproduction

View full text Add to dashboard Cite

Pregnancy and neonatal outcomes following letrozole use in frozen–thawed single embryo transfer cycles

Abstract: Not applicable.

Cited by 65 publications

References 8 publications

Advanced paternal age alone does not adversely affect pregnancy or live‐birth rates or sperm parameters following intrauterine insemination

Advanced paternal age alone does not adversely affect pregnancy or live‐birth rates or sperm parameters following intrauterine insemination

Pregnancy Outcomes Following Letrozole Use in Frozen-thawed Embryo Transfer Cycles: A Systematic Review and Meta-analysis

Androgens for Improving Ovarian Response to Stimulation

Contact Info

Product

Resources

About