Pregnancy and neonatal outcomes in women with type 1 diabetes mellitus

Durackova, L; Krištúfková, Alexandra; Korbeľ, M

doi:10.4149/bll_2017_011

Cited by 16 publications

(14 citation statements)

References 18 publications

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“…Its frequency has been reported between 60% and 78%. [91112] The cesarean ratio was 72% in our cases. Even in the most favorable conditions, a pregnant patient with T1DM is likely to deliver by cesarean section.…”

Section: Discussionmentioning

confidence: 49%

“…[78] It has been reported that preeclampsia developed in 19.1% of patients without vasculopathy and 49.1% of the diabetic patients with vasculopathy. [9] Our preeclampsia cases were not with chronic hypertension. In the cases with chronic hypertension the preeclampsia ratio would be much more higher.…”

Section: Discussionmentioning

confidence: 82%

“…The macrosomia ratio was 54% in the non-vascuopathic group. [9] The most common indication of cesarean section was repeated cesarean section [Table 1].…”

Section: Discussionmentioning

confidence: 99%

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Pregnancy outcomes in women with strictly controlled type 1 diabetes mellitus

Çilingir

2018

Indian J Endocr Metab

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Objective:To evaluate the pregnancy outcomes in mothers with controlled Type 1 diabetes mellitus (T1DM).Materials and Methods:Thirty seven pregnant patients with controlled T1DM were included in the study.Results:Twenty (54%) out of 37 patients had preterm delivery (<37 weeks of gestation). The type of delivery was induced vaginal delivery in 9 (24.3%) patients and cesarean section in 27 (72.9%) patients. Preeclampsia developed in 6 (16.2%) patients. Macrosomia was found in 9 (24%) patients. Two antenatal death occured.Conclusion:Even in the most favorable conditions, the pregnant patients with T1DM would have a great risk for preterm delivery and cesarean section, moderate risk for macrosomia, preeclampsia, and an undefined risk for antenatal death.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 82%

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Pregnancy outcomes in women with strictly controlled type 1 diabetes mellitus

Çilingir

2018

Indian J Endocr Metab

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“…Even in high-risk newborns, the optimal diet is enteral. Since the newborns of mothers without optimal metabolic compensation during pregnancy are at risk of postnatal hypoglycaemia, the initiation of enteral nutrition is desirable also for babies of mothers with diabetes mellitus, (6). By analysing the breast milk, we are able to optimize newborn enteral nutrition with fortifi ers.…”

Section: Introductionmentioning

confidence: 99%

Exact determination of optimal nutritional composition for at-risk newborns tolerating enteral intake–breast milk analysis as a routine future standard in neonatal care

Macakova¹,

Letenayova²,

Tulejova³

et al. 2019

BLL

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AIM: To analyse the dynamics of macronutrients in breast milk in Slovakian women and compare the dynamics between mothers of hospitalized newborns and donors of human breast milk relative to the gestational age of their babies. METHODS: Human milk samples were collected from 101 breastfeeding women and analysed once or repeatedly from September 2017 to August 2018. Group A consisted of 79 mothers of newborns hospitalized at the Neonatal Department of Intensive Medicine (NDIM) of whom 69 were mothers of premature newborns (subgroup A1) and 10 were mothers of term babies (subgroup A2). Group B consisted of 22 breast milk donors registered at the Human Milk Bank at National Institute of Children's Diseases (NICHD). Of these, 4 were mothers of premature newborns (subgroup B1) and 18 were mothers of term newborns (subgroup B2). From subgroup A1, we chose two mothers, one with a hypotrophic newborn and another with a eutrophic newborn. The results were obtained by using the MIRIS breast-milk analyzer. RESULTS: The overall dynamics of macronutrients correspond with other studies, however, we demonstrated that the level of macronutrients in individual cases were different. CONCLUSION: The determination of macronutrients in human milk is essential in neonatal care. It provides information about the nutritional value of breast milk and helps to optimise nutrition according to the individual needs of newborns (Fig. 10, Ref. 16). Text in PDF www.elis.sk.

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“…The affected newborns may suffer metabolic syndrome, risk of obesity and respiration distress [1,4]. Growing population of infants with metabolic syndrome as a consequence of maternal diabetic condition raises the great concern about cardiovascular disease developed already in adolescents [5].…”

mentioning

confidence: 99%

Perinatal changes in plasma of type 2 diabetes mellitus pregnancies who delivered newborns with cardiomyopathy, depression of the central nervous system, or hepatomegaly

Kopylov

Папышева

Gribova³

et al. 2020

Preprint

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Background Maternal diabetes either pregestational or gestational is the main risk factor contributing in development of diabetic fetopathy (DF) in newborns. There are no generalized signs of DF up to late gestational age due to insufficient sensitivity of the currently employed instrumental methods for diagnosis. Methods This is a cross-sectional prospective controlled study. Here, we reported proteomic investigation for several cases of severe types of diabetic fetopathy (cardiomyopathy (CRDM, n = 37), central nervous system depression (CNSD, n = 35) and hepatomegaly (HPMG, n = 35)) diagnosed during 30–35 gestational weeks and confirmed upon delivery by from patients with type 2 diabetes mellitus (T2DM). Control groups were comprised from women in whom T2DM had been ruled out (n = 40) and group of pregnancies with T2DM who delivered healthy newborns (n = 40). Results We found a composition of serum-based non-trivial markers capable that are strongly associated with the certain type of fetopathy or anatomical malfunctions in the affected newborns. Significant impact on mRNA splicing and DNA reparation has been determined by emerging alterations in CDCL5. Patients of CNSD groups were characterized by utmost depletion (ca. 7% of baseline) of DFP3 neurotrophic factor needed for the proper specialization of cardiomyocytes and oligodendrocytes. Corrupted regulation of non-canonical Wnt-signaling guided by PEDF (in CNSD and HPMG groups) and DAAM2 (in CRDM and HPMG groups) was also proposed. In addition, deficiency in retinoic acid and thyroxine transport was revealed by dramatic increase of TTHY in CNDS group. Conclusions We examined peripheral blood plasma and determined a small proportion of proteins indicating the pre-existing signs of DF. Most of the examined markers are participants of critical processes at different stages of embryogenesis and regulate various phases of morphogenesis. There are proteins regulating splicing and DNA repair, differentiation of neurons and their switching to the post-mitotic state. Therefore, reconstruction of the molecular interplay between the defined in proteins is decisive to appreciate cryptic violations in fetal development on the background of diabetic conditions

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Pregnancy and neonatal outcomes in women with type 1 diabetes mellitus

Cited by 16 publications

References 18 publications

Pregnancy outcomes in women with strictly controlled type 1 diabetes mellitus

Pregnancy outcomes in women with strictly controlled type 1 diabetes mellitus

Exact determination of optimal nutritional composition for at-risk newborns tolerating enteral intake–breast milk analysis as a routine future standard in neonatal care

Perinatal changes in plasma of type 2 diabetes mellitus pregnancies who delivered newborns with cardiomyopathy, depression of the central nervous system, or hepatomegaly

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