Pregnancy and the Kidney

Lipkin, Graham; Day, Clara; Jurawan, Nerissa; Johnston, Tracey; Knox, Ellen

doi:10.1007/978-1-4471-5547-8_33

Cited by 1 publication

(3 citation statements)

References 47 publications

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Section: Physiological Changes During Pregnancymentioning

confidence: 99%

“…Renal diseases are frequently found in pregnant women partially because of the hormonal and hemodynamic changes that occur during pregnancy that can impact renal function, leading to less functional reserve [ 24 , 25 ]. The kidneys increase in length and volume, and physiologic hydronephrosis occurs in up to 80% of women during pregnancy [ 24 , 25 ]. Hormonal changes during pregnancy allow for increased blood flow to the kidneys and altered renal autoregulation, such that glomerular filtration rate (GFR) increases significantly through reductions in net glomerular oncotic pressure and increased renal size.…”

Section: Physiological Changes During Pregnancymentioning

confidence: 99%

“…As a result, the GFR increases by approximately 50% with subsequent decreases in serum creatinine, urea, and uric acid values. The antidiuretic hormone secretion is generally depressed, resulting in lower osmolality and serum sodium levels, whereas the rise in progesterone levels protects the pregnant woman from hypokalemia [ 24 , 25 ].…”

Section: Physiological Changes During Pregnancymentioning

confidence: 99%

See 2 more Smart Citations

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Ferreira

Blasina

Rey

et al. 2022

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.

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