Pregnancy associated breast cancer: Correlation between Parity and Prognostic Factors

Abstract

Background and Purpose Pregnancy associated breast cancer (PABC) has attracted more attention recently. Previous studies have focused on comparison between the prognosis of PABC and non-PABC. This study aimed to investigate the correlation between parity and prognostic factors of PABC. Methods In this retrospective study, patients with PABC who underwent surgery at Fudan University Shanghai Cancer Center between 2017 and 2021 were analyzed. Data concerning tumor characteristics, reproductive history and survival outcome were recorded. Results In total, the median age of 203 patients enrolled was 34 years (range, 22 years to 46 years). Compared with primiparous group, multiparous group had higher rate of clinical stage III ~ IV [33.9% (41/121) vs 18.3% (15/82), P < 0.001], higher rate of IDC of histological grade III [72.9% (62/85) vs 62.5% (40/64), P = 0.002], higher rate of lymphatic metastasis [57.0% (69/121) vs 41.5% (34/82), P = 0.030]. Among the patients who underwent neoadjuvant chemotherapy, multiparous group had higher rate of pathological complete response than primiparous group [57.8% (26/45) vs 34.4% (11/32), P = 0.043]. The 2-year disease-free survival rate of primiparous and multiparous group were 82.0% and 74.2% respectively (P = 0.212). Conclusions Multiparity was correlated with worse prognostic factors in PABC patients, but no evidence suggesting correlation with worse survival yet.