Pregnancy-associated-cancer in the French West Indies (Martinique): maternal and neonatal outcomes

Melan, Kathleen; Voluménie, Jean-Luc; Wan-Ajouhu, Gaël; Ulric-Gervaise, Stephen; Véronique-Baudin, Jacqueline; Joachim, Clarisse

doi:10.1186/s12884-017-1524-0

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…Pregnancy-associated cancer (PAC) is defined as a malignancy that occurs during pregnancy or within 12 months after delivery [ 1 ] and has an incidence of 1 in 1000 pregnancies, which increases with maternal age. Malignancy that more frequently develop during pregnancy (e.g., breast cancer, cervical cancer, ovarian cancer, melanoma, thyroid cancer, lymphoma, and leukemia) are those that typically present a peak of incidence during re-productive ages [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Neonatal outcomes and follow-up of children born to women with pregnancy-associated cancer: a prospective observational study

Capozza,

Romano,

Mastrangelo

et al. 2024

BMC Pregnancy Childbirth

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Background During the last decade, there has been a growing number of cases of children born from pregnancy-associated cancer (PAC), however there are currently insufficient data on the follow up to be observed in this category of newborns. Objective of the study was to evaluate the neonatal outcomes of infants born to mother with PAC, the potential adverse effect of chemotherapy during pregnancy and the risk of metastasis to the fetus. Methods Maternal clinical data and neonatal outcomes of child born to mothers diagnosed with PAC were collected; infants were divided into those were and were not exposed to chemotherapy during fetal life and their outcomes were compered. Results A total of 37 newborn infants from 36 women with PAC were analyzed. Preterm delivery occurred in 83.8% of the cases. No significant differences in neonatal outcomes were found between infants who were and were not exposed to chemotherapy during pregnancy. The median follow-up period was 12 months. Conclusions PAC treatment during the second or third trimester does not seem to be dangerous for the fetus, however infants born from PAC must be carefully evaluated for to rule out the consequences of chemotherapy and exclude the presence of metastasis. Long-term follow-up, especially in children exposed to chemotherapy, should be encouraged to obtain relevant data on long-term toxicity.

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Section: Introductionmentioning

confidence: 99%

Neonatal outcomes and follow-up of children born to women with pregnancy-associated cancer: a prospective observational study

Capozza,

Romano,

Mastrangelo

et al. 2024

BMC Pregnancy Childbirth

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Awareness towards an increasing concern during pregnancy: maternal and perinatal outcomes of women with cancer

Puzzi-Fernandes

Surita

Schettini

et al. 2020

American Journal of Obstetrics & Gynecology MFM

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BACKGROUND: Increased incidence of cancer in women of childbearing age and improvements on treatment for preserving fertility have led to higher frequency of pregnancy during or after cancer treatment. OBJECTIVE: This study aimed to describe maternal and perinatal outcomes associated with cancer and pregnancy and, as a secondary analysis, to compare outcomes of women with active disease and with remission before pregnancy. STUDY DESIGN: We performed a retrospective study of women followed up at a referral center owing to a history of cancer or cancer diagnosed during pregnancy. Data on sociodemographic information, obstetrical history, types of neoplasia, treatments offered, antenatal follow-up, and maternal and perinatal outcomes were retrieved from medical chart review. A descriptive analysis was performed and a comparison among women with active and nonactive disease was performed using Student t-test and chi-square test. RESULTS: A total of 66 women were included in a 5-year period. The most frequent types of cancer were breast (33%), hematologic (21%), brain (11%), cervical (9%), and ovarian (5%) cancers. There were 39 participants (59%) who had active disease and 26 who received oncological treatment during pregnancy, and 23 (34.8%) had a vaginal delivery. There were 4 women who needed intensive care unit admission postpartum. A total of 18 (29.5%) deliveries were at term, most newborns (59%) with adequate weight for gestational age and only 1 had Apgar score lower than 7 in the fifth minute of life. There was 1 stillbirth. The active invasive cancer during pregnancy group showed a higher rate of preterm birth and lower birthweight with significant statistical difference (P¼.03 and P<.01, respectively). CONCLUSION: Breast cancer was the most frequent type of cancer in our cohort. Most deliveries were preterm, with adequate birthweight. Women with active cancer are more likely to have a preterm childbirth and newborns with lower birthweight.

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Cohort profile: the Martinique Cancer Registry and the quality of life prostate cancer cohort (QoL Prostate-MQ): challenges and prospects for reducing disparities in the Caribbean

et al. 2018

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PurposeRecording cancer data in cancer registries is essential for producing reliable population-based data for service planning, monitoring and evaluation. Prostate cancer (PCa) remains the most frequent type of cancer in terms of incidence and mortality in men in the Caribbean. The quality of life PCa cohort will assess quality of life and patient outcomes in Martinique using a digital platform for patient-reported outcome measures.ParticipantsThe Martinique Cancer Registry database is the largest clinical database among the French population-based cancer registries in the Caribbean, including more than 38 000 cancer cases, with 1650 new cancer cases per year, including 550 new PCa cases per year (2010–2014 latest period). In 2018, follow-up will include vital status, assessment of quality of life with the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ) Core 30 and the Prostate cancer module QLQ-PR25. Urinary incontinence and erectile dysfunction recorded prior to treatment will be analysed 1 and 5 years after treatment.Findings to dateThe registry includes data on circumstances of diagnosis, clinical stage at diagnosis. For PCa, the registry includes blood prostate-specific antigen level at the time of diagnosis, Gleason score and primary treatment.Future plansFurther studies will provide detailed data regarding the quality of diagnosis and management of patients with PCa in Martinique; analysing quality of care will be the next challenge.Quality of life and patient outcomes will be evaluated using a digital platform for patient-reported outcome measurement and electronic records.

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Pregnancy-associated-cancer in the French West Indies (Martinique): maternal and neonatal outcomes

Cited by 7 publications

References 22 publications

Neonatal outcomes and follow-up of children born to women with pregnancy-associated cancer: a prospective observational study

Neonatal outcomes and follow-up of children born to women with pregnancy-associated cancer: a prospective observational study

Awareness towards an increasing concern during pregnancy: maternal and perinatal outcomes of women with cancer

Cohort profile: the Martinique Cancer Registry and the quality of life prostate cancer cohort (QoL Prostate-MQ): challenges and prospects for reducing disparities in the Caribbean

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