Pregnancy-Associated Listeriosis: Clinical Characteristics and Geospatial Analysis of a 10-Year Period in Israel

Elinav, Hila; Klement, Anat Hershko; Valinsky, Lea; Jaffe, Joseph; Wiseman, Anat; Shimon, Hila; Braun, Eyal; Paitan, Yossi; Block, Colin; Sorek, Rotem; Nir-Paz, Ran; Miron, Dan; Glikman, Daniel; Soboh, S.; Nseir, William; Paz, A. Moguel; Cohen, Elizabeth; Mendelson, Bracha; Paz, Esteban Vaucheret; Shimoni, Zvi; Wattad, Malak; Ravid, Mordchai; Keller, Nathan; Rahav, Galia; Dan, Michael; Shechner, V.; Weinberger, Miriam; Nadir, Erez; Troshin, T.; Riesenberg, Klaris; Tsabari, Avinoam; Lachish, Tamar; Halperin, Ehud; Anis, Emilia; Vasiliev, Valery V.; Japeth, R.

doi:10.1093/cid/ciu504

Cited by 76 publications

(83 citation statements)

References 28 publications

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“…This is lower when compared to other countries; for example in the United States of America the incidence of neonatal listeriosis is 8.6 per 100,000 live births [15] and in Israel it is up to 25.5 per 100,000 live births [16]. Neonatal listeriosis is also rarer when compared to the more common cause M A N U S C R I P T…”

Section: Discussionmentioning

confidence: 99%

Neonatal listeriosis in the UK 2004–2014

Sapuan

Kortsalioudaki

Anthony

et al. 2017

Journal of Infection

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ObjectiveTo define the clinical features and outcomes of neonatal listeriosis, and identify the maternal risk factors to seek scope for improvement. MethodsNeonatal listeriosis was identified prospectively from a United Kingdom neonatal infection surveillance network (neonIN) between 2004 and 2014. The participating neonatal units completed a study-specific proforma. ResultsThe incidence of neonatal listeriosis was 3.4 per 100,000 live births. Of the 21 cases identified, 19 were confirmed with a median gestational age of 33 weeks and a median birth weight of 1960g. The majority had clinical features (95%, 18/19), presented within the first 24 hours (95%, 18/19), and received penicillin empirically (94%, 18/19). The neonatal casefatality rate was 21% (24% if probable cases were included). A proportion of mothers were investigated (60%, 12/18) and diagnosed with listeriosis (58%, 7/12); 32% (6/19) were treated with antibiotics but only 33% (6/12) included penicillin. DiscussionDespite its rarity and the prompt and appropriate use of antibiotics neonatal listeriosis has a high case-fatality rate. There is room for improvement in the adherence to the national guidance in the choice of empiric antibiotics for puerperal sepsis, which would target listeriosis. Strategies should be in place to prevent pregnancy-associated listeriosis in higher risk population.

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Section: Discussionmentioning

confidence: 99%

Neonatal listeriosis in the UK 2004–2014

Sapuan

Kortsalioudaki

Anthony

et al. 2017

Journal of Infection

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“…However, different ECs may have different pathways of infection in, or tropism for, different tissues or cells within the human body. For example, a recent study suggested "pregnancy predilection" for ECIV, as this clone clearly plays a major role in cases of listeriosis associated with pregnancy (Elinav et al, 2014).…”

Section: Adaptive Epidemic Clones (Ecs) Of L Monocytogenesmentioning

confidence: 99%

The evolution and epidemiology of Listeria monocytogenes in Europe and the United States

Lomonaco

Nucera

Filipello

2015

Infection, Genetics and Evolution

188

125

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“…In recent years, epidemiology of pregnancy-related listeriosis has been investigated in several developed countries, such as England and Wales [13], France [14], United States [3], Netherlands [15], and Israel [16]. A proportion between 20.7% [5] and 43% [17] of L. monocytogenes invasive infections are related to pregnancy.…”

Section: Introductionmentioning

confidence: 99%

“…Between 1984 and 2011 this indicator in France fell from 60 to 5 cases per 100000 live births, which is a decline by a factor of 12 [14]. Conversely, in the years 1998–2007 the yearly incidence of pregnancy-associated listeriosis in Israel ranged from 5.5 to 25.2 cases per 100000 births [16]. In USA, application of preventive measures (“zero tolerance”) since 1985 resulted in a 44% reduction of perinatal listeriosis, from 17.4/100000 to 8.6/100000 live births [8].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology and Molecular Typing of Pregnancy-Associated Listeriosis Cases in Lombardy, Italy, over a 10-Year Period (2005–2014)

Filipello

Amato

Gori

et al. 2017

Infectious Diseases in Obstetrics and Gynecology

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In developed countries, pregnancy-related listeriosis accounts for 20–43% of total invasive listeriosis. This work describes the first pregnancy-related listeriosis survey in Italy based on two data sources, that is, mandatory notification system and regional laboratory-based network. Out of 610 listeriosis cases reported over a 10-year period, 40 were pregnancy-related (6.6%). Among these, 29 pregnancy-related isolates were available and have been analysed with serotyping, Pulsed-Field Gel Electrophoresis, and Multi-Virulence-Locus Sequence Typing. No maternal fatality was recorded, but 11 (29.7%) pregnancies resulted in a foetal death, a miscarriage, or a birth of a foetus dying immediately after birth. The average incidence of pregnancy-related listeriosis was 4.3 cases per 100000 births, and the proportion of pregnancy-associated listeriosis among ethnic minorities was significantly higher compared to the general population (30.0% versus 3.5%, P < 0.01). L. monocytogenes isolates belonged to serotypes 1/2a, 1/2b, and 4b, with the latter significantly more prevalent among pregnancy-related isolates. Twenty different pulsotypes were distinguished and 16 out of the 29 isolates were classified into seven clusters. A total of 16 virulence types (VTs) were identified. Five VTs accounted for 45% of the total cases and coincided with those of previously described Epidemic Clones (ECs) of L. monocytogenes.

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Pregnancy-Associated Listeriosis: Clinical Characteristics and Geospatial Analysis of a 10-Year Period in Israel

Abstract: Our survey emphasizes the high rate of pregnancy-related listeriosis in Israel and shows that specific clones might account for this.

Cited by 76 publications

References 28 publications

Neonatal listeriosis in the UK 2004–2014

Neonatal listeriosis in the UK 2004–2014

The evolution and epidemiology of Listeria monocytogenes in Europe and the United States

Epidemiology and Molecular Typing of Pregnancy-Associated Listeriosis Cases in Lombardy, Italy, over a 10-Year Period (2005–2014)

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