Pregnancy-associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome

Abstract

Background/aim: To evaluate pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), procalcitonin, and troponin I levels as diagnostic markers of acute coronary syndrome in patients admitted to the emergency department. Materials and methods:The serum PAPP-A, IMA, procalcitonin, and troponin I levels were measured in 100 patients with acute coronary syndrome admitted to the emergency department and 100 healthy control subjects.Results: Patients with acute coronary syndrome had significantly greater mean serum PAPP-A

Serum Concentrations of Ischaemia-Modified Albumin in Acute Coronary Syndrome: A Systematic Review and Meta-Analysis

“…The 18 selected studies included 32 comparator arms in 1654 ACS patients (mean age 60 years, 60% men) and 1023 healthy controls or subjects with atypical chest pain without ACS (mean age 53 years, 58% men) ( Table 1 ) [ 11 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. IMA was measured using automated analysers in two studies [ 24 , 35 ], enzyme-linked immunosorbent assay in one [ 31 ], and the spectrophotometric albumin cobalt binding assay in the remaining 15 [ 11 , 21 , 22 , 23 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 33 , 34 , 36 , 37 ]. Six comparative arms investigated overall ACS [ 21 , 22 , 25 , 28 , 29 , 34 ], two overall AMI [ 24 , 26 ], seven STEMI [ 11 , 27 , 30 , 31 , 33 , 35 , 36 ], nine NSTEMI [ ...…”

“…IMA was measured using automated analysers in two studies [ 24 , 35 ], enzyme-linked immunosorbent assay in one [ 31 ], and the spectrophotometric albumin cobalt binding assay in the remaining 15 [ 11 , 21 , 22 , 23 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 33 , 34 , 36 , 37 ]. Six comparative arms investigated overall ACS [ 21 , 22 , 25 , 28 , 29 , 34 ], two overall AMI [ 24 , 26 ], seven STEMI [ 11 , 27 , 30 , 31 , 33 , 35 , 36 ], nine NSTEMI [ 11 , 27 , 30 , 31 , 32 , 33 , 35 , 36 , 37 ], and eight UA [ 11 , 23 , 26 , 27 , 30 , 31 , 33 , 35 ]. In all studies, IMA was measured within 24 h of the onset of symptoms [ 11 , 21 , 22 , 23 ...…”

“…Six comparative arms investigated overall ACS [ 21 , 22 , 25 , 28 , 29 , 34 ], two overall AMI [ 24 , 26 ], seven STEMI [ 11 , 27 , 30 , 31 , 33 , 35 , 36 ], nine NSTEMI [ 11 , 27 , 30 , 31 , 32 , 33 , 35 , 36 , 37 ], and eight UA [ 11 , 23 , 26 , 27 , 30 , 31 , 33 , 35 ]. In all studies, IMA was measured within 24 h of the onset of symptoms [ 11 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

“…The forest plot of IMA concentrations in ACS patients and controls is shown in Figure 2 . In two comparator arms from the same study, IMA concentrations were either lower in ACS patients, or virtually identical between ACS patients and controls [ 27 ]. In the remaining comparator arms, ACS patients had higher IMA concentrations, although the difference was not significant in two [ 27 , 37 ].…”

“…In two comparator arms from the same study, IMA concentrations were either lower in ACS patients, or virtually identical between ACS patients and controls [ 27 ]. In the remaining comparator arms, ACS patients had higher IMA concentrations, although the difference was not significant in two [ 27 , 37 ]. There was substantial heterogeneity (I 2 = 97%, p < 0.001).…”