2012
DOI: 10.1016/s0019-4832(12)60049-2
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Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome

Abstract: Aims and objectives: Pregnancy associated plasma protein-A (PAPP-A), a metalloproteinase plays apivotal role in the pathogenesis of atherosclerosis. Recent studies have reported that elevated levels of PAPP-A, signal the onset of acute coronary syndrome (ACS). We, therefore, proposed to study the analytical competence of PAPP-A in patients admitted to the emergency department with chest pain and finally diagnosed as ACS. Methods and results:Pregnancy associated plasma protein-A was measured using enzyme-linked… Show more

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Cited by 18 publications
(10 citation statements)
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“…123,124 PAPP-A showed a good correlation with risk stratification 125 and adverse cardiac events in ACS patients, 126 with a release pattern between 2 and 30 hours after cell damage. 127 An extensive meta-analysis by Long et al 128 involving 14 studies of PAPP-A and ACS suggested that a higher level of PAPP-A could indicate a moderate increase in the long-term risk of adverse cardiovascular outcomes, supporting its further investigation as a valuable prognostic predictor in ACS.…”
Section: Papp-amentioning
confidence: 86%
“…123,124 PAPP-A showed a good correlation with risk stratification 125 and adverse cardiac events in ACS patients, 126 with a release pattern between 2 and 30 hours after cell damage. 127 An extensive meta-analysis by Long et al 128 involving 14 studies of PAPP-A and ACS suggested that a higher level of PAPP-A could indicate a moderate increase in the long-term risk of adverse cardiovascular outcomes, supporting its further investigation as a valuable prognostic predictor in ACS.…”
Section: Papp-amentioning
confidence: 86%
“…Utility of PAPP-A as a clinical cardiac biomarker will require assay standardization and finding an optimal cut-off accordingly in addition to further clinical investigations. Elucidation of the actions of PAPP-A in the unstable plaque may hold the promise of leading to the development of specific plaquedirected therapies for the treatment of both stable and unstable coronary syndromes [13].…”
Section: Discussionmentioning
confidence: 99%
“…It has been thought that PAPP-A might be a marker of unstable plaque rupture in patients with sudden cardiac death [9]. The elevation of PAPP-A may be an independent predictor of ischemic events [10]. There is a weak correlation between PAPP-A and CK-MB; thus, the elevation of PAPP-A may not be related to necrosis.…”
Section: Discussionmentioning
confidence: 99%