Pregnancy-Associated Sweet’s Syndrome: A Rare Clinical Entity

Madhavi, Sankar; Karthikeyan, Kaliaperumal

doi:10.1007/s13224-015-0816-4

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…9 1, requiring confirmation of two major and two minor criteria, all of which were present in our patient. 10 Rawtani HA et al Int J Reprod Contracept Obstet Gynecol. 2022 Jul;11 (7):2052-2055…”

Section: Discussionmentioning

confidence: 99%

Sweet’s syndrome in pregnancy: a rare case report

Rawtani

Chandrashekhar²,

Phulpaghar³

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Sweet’s syndrome (SS) is a steroid-responsive dermatological condition characterized by fever, neutrophilia and a classical tender erythematous skin rash. Pregnancy-associated SS is an extremely rare clinical entity and must be kept in mind while approaching a case of skin rash in pregnancy. We reported a rare case of SS in pregnancy with classical features and characteristic histopathological features of neutrophilic dermatosis that had a benign course, resolving with topical steroid treatment instead of the usual systemic steroids.

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Section: Discussionmentioning

confidence: 99%

Sweet’s syndrome in pregnancy: a rare case report

Rawtani

Chandrashekhar²,

Phulpaghar³

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Sweet syndrome in pregnancy: A narrative review

Glennon,

Tan,

Prabhu

et al. 2024

Intl J Gynecology & Obste

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The aim of this review is to increase obstetrician awareness of pregnancy‐associated Sweet syndrome. Patients present with fever, leukocytosis, and skin eruption, which can mimic other infectious or inflammatory conditions, but do not respond to antibiotics. A search using PubMed, EMBASE, and Web of Science Core Collection was conducted to review all reported cases of pregnancy‐associated Sweet syndrome, an acute febrile neutrophilic dermatosis occurring during pregnancy or postpartum. A total of 33 episodes among 30 patients were identified, with the majority (54.5% [18]) of cases occurring within the second trimester. Among the 30 patients, skin lesions most commonly affected the head and neck (73.3% [22]), with rare oral or ocular involvement. Leukocytosis was the most common laboratory finding, reported in 96.7% [29] of patients, with neutrophil predominance noted in 70.0% [21]. The diagnosis was confirmed for all patients with pathognomonic results of skin biopsies. Of the 27 cases detailing treatment, systemic corticosteroids were most frequently used (19 cases), followed by conservative management (seven cases), and dapsone (one case). The dapsone‐treated patient and 15 of the 19 steroid‐treated patients experienced resolution, but additional management strategies were required in the remaining four individuals. Spontaneous resolution occurred during pregnancy in six of the seven conservatively managed individuals, with one patient experiencing spontaneous abortion shortly after skin eruption at 10 weeks of gestation. No associated maternal deaths were reported. Obstetric complications of pregnancy‐associated Sweet syndrome included endomyometritis, sterile placental abscesses, and abdominal wall necrosis. Delivery of healthy infants occurred in 24 of the 25 cases that presented fetal outcome, which included two infants who underwent medically indicated preterm deliveries.

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