Pregnancy complications in women with rare tumor suppressor syndromes affecting central and peripheral nervous system

Terry, Anna R.; Merker, Vanessa L.; Barker, Frederick G.; Leffert, Lisa; Bateman, Brian T.; Souter, Irene; Plotkin, Scott R.

doi:10.1016/j.ajog.2015.02.013

Cited by 7 publications

(8 citation statements)

References 5 publications

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“…22 Terry AR et al report that a more common complication in NF2 patients is preeclampsia, which is caused by a decrease in the ability of vascular dilators. 4 In their study, periodic evaluation of the fetus by assessing the biophysical profile, fetal weight growth, and Doppler velocimetry assessment, showed no signs of impaired fetal development. Additionally, maternal evaluation of cardiovascular disorders and preeclampsia risk which is routinely checked, did not show any of such diseases and complications.…”

Section: Discussionmentioning

confidence: 94%

“…Additionally, pregnant women with NF2 have a high risk of developing hypertension, preeclampsia, cardiovascular problems, and Intrauterine growth restriction (IUGR). 4 They should be notified by their physician that this is an inherited disease and there is a 50% chance that their baby will Inherit this disease. Appropriate steps and supervision during pregnancy up to the birth process are needed to reduce pregnancy morbidity.…”

Section: Introductionmentioning

confidence: 99%

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Case Report: Rare Case of NF2 in Pregnancy with Favorable Maternal and Perinatal Outcome, Under General Anesthesia Caesarean Section

et al. 2022

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Background: Neurofibromatosis type 2 (NF2) is an autosomal dominant disease due to chromosome 22 (22q12.2) mutation with a prevalence of 1:33,000-40,000. As many as 50% of cases are familial, 30-60% are genetic mosaic, de novo mutations. Tumor growth in NF often becomes more rapid in pregnancy. Pregnancy with NF2 has a risk of complications of hypertension, preeclampsia, cardiovascular problems, and IUGR (Intrauterine growth restriction). Case Reports: A 26-year-old woman, 29/30 weeks gestational age complaint of visual impairment, hearing loss, and multiple body masses. The results of MRI examination of the Head and whole Spine with contrast showed bilateral vestibular schwannoma, meningiomatosis, cervical schwannoma (C1-C5), which were features of NF2. Routine clinical evaluation, laboratory tests, fetal growth examination, and multidisciplinary management were performed during the antenatal care. There were no signs of increased intracranial pressure, hydrocephalus, and complications of preeclampsia, fetal abnormalities, or IUGR. A termination at 37 weeks of gestation with Caesarean Section and General Anesthesia was decided to reduce the increase of intracranial pressure during labor. A male infant was born with a birth weight of 2600 grams, without any abnormalities. Conclusion: Pregnancy in NF2 patient has a potential risk of tumor growth progression, preeclampsia, and IUGR, therefore it is necessary to monitor and evaluate the mother and fetus multidisciplinary during the pregnancy process to get good maternal and fetal outcomes. The mode of delivery in neurofibromatosis is determined mainly by obstetric indications.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Case Report: Rare Case of NF2 in Pregnancy with Favorable Maternal and Perinatal Outcome, Under General Anesthesia Caesarean Section

et al. 2022

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“…Stroke, acute vascular rupture, hypertension, preeclampsia, low platelet count, HELLP syndrome, and eclampsia have been reported (Terry et al 2015, Leppavirta et al 2017). 13 , 14 Particularly, hypertension due to pheochromocytoma or paragangliocytoma may change the prognosis for the mother and the fetus (Walther et al 1999). 15 Nevertheless, maternal mortality in compliant patient with NF1 is rare.…”

Section: Discussionmentioning

confidence: 99%

“…Pregnancies have been reported in women with NF1, but concerns exist for the mother and the fetus. Stroke, acute vascular rupture, hypertension, preeclampsia, low platelet count, HELLP syndrome, and eclampsia have been reported (Terry et al 2015, Leppavirta et al 2017) 13,14 . Particularly, hypertension due to pheochromocytoma or paragangliocytoma may change the prognosis for the mother and the fetus (Walther et al 1999) 15 .…”

Section: Discussionmentioning

confidence: 99%

Neurofibromatosis and HIV infection in a pregnant woman

Pepe¹,

Mininni²,

Zambrotta³

et al. 2021

Clinical Case Reports

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“…Concerns for the mother are related to stroke (mostly hemorrhagic), acute vascular rupture (overall incidence of vascular anomalies is estimated (0.49-6.4%), hypertension, preeclampsia, low platelet count, HELLP syndrome and eclampsia [56,67,68]. Particularly hypertension due to pheochromocytoma may change the prognosis for the mother and the fetus [69].…”

mentioning

confidence: 99%

Reproductive Issues in Neurofibromatosis Type 1: An Update

2021

Archives of Obstetrics and Gynaecology

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Many factors have ameliorated prognosis for individual with NF1: higher knowledges and awareness on the disease, early diagnosis, better clinical counseling in reference centers, appropriate surveillance of symptoms, early surgical therapy in growing neurofibromas and better cosmetic treatment [3].There is an 8-15 years reduction in average life expectancy and malignancies and cardiovascular disease are the most frequent causes of death [8,9]. On 2,467 Danish patients with NF1 diagnosis, nerve and peripheral ganglia disease, pneumonia, epilepsy, bone and joint disorders, and intestinal infections were major contributors to the excess disease burden due to the disease [10]. Non-tumor symptoms contribute significantly to morbidity especially in relation to size, location of tumor/s and growth velocity

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Pregnancy complications in women with rare tumor suppressor syndromes affecting central and peripheral nervous system

Cited by 7 publications

References 5 publications

Case Report: Rare Case of NF2 in Pregnancy with Favorable Maternal and Perinatal Outcome, Under General Anesthesia Caesarean Section

Case Report: Rare Case of NF2 in Pregnancy with Favorable Maternal and Perinatal Outcome, Under General Anesthesia Caesarean Section

Neurofibromatosis and HIV infection in a pregnant woman

Reproductive Issues in Neurofibromatosis Type 1: An Update

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