Pregnancy Following the “Insensitive Ovary Syndrome”

Shangold, Mona M.; Turksoy, R. Nuran; Bashford, Robert A.; Hammond, Charles B.

doi:10.1016/s0015-0282(16)42914-6

Cited by 73 publications

(26 citation statements)

References 14 publications

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“…This patient is currently under study. It may be important to distinguish such cases from other syndromes such as premature menopause (which was the initial diagnosis for our patient), since the presence of ovarian follicles in these patients may allow the treatment of their infertility in the future (44,48). Comparison with residues present in FSHR of other species and in LHR or TSHR.…”

Section: Discussionmentioning

confidence: 97%

A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor.

Beau

Touraine²,

Meduri³

et al. 1998

J. Clin. Invest.

261

173

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A single natural loss of function mutation of the follicle stimulating hormone receptor (FSHR) has been described to date. Present in the Finnish population it markedly impairs receptor function, blocking follicle development at the primary stage and presenting as primary amenorrhea with atrophic ovaries. When Western European women with this phenotype were examined for FSHR mutations the result was negative, suggesting that other etiologies corresponding to this clinical pattern are markedly more frequent.We

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Section: Discussionmentioning

confidence: 97%

A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor.

Beau

Touraine²,

Meduri³

et al. 1998

J. Clin. Invest.

261

173

View full text Add to dashboard Cite

show abstract

“…A number of treatment regimens have been evaluated with the aim of restoring fertility; however, treatments with clomiphene, gonadotropins, gonadotropin-releasing hormone (GnRH) agonists, or immunosuppression do not significantly improve the chance of conception. 11,13,15 Cryopreservation of ovarian tissue or oocytes for later in vitro growth and maturation may be possible; however, women who are presenting with symptoms of POI will most likely have follicles that are of lower quality, this would require that only women who were aware of future impending ovarian failure. 22,27 At present, in vitro maturation of immature follicles is possible, but in vitro growth and maturation from stored ovarian tissue is not reliably achievable in humans.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8] Several noninvasive methods, such as transvaginal ultrasonography and autoantibody measurement, have been advocated, but no consensus has been established on their usefulness. [9][10][11][12][13] Unfortunately, both ovaries could not be visualized using pelvic ultrasound in most cases with POI. The objective of this method was to evaluate the effectiveness of office microlaparoscopy with the patient under augmented local anesthesia first to assess the morphology of both ovaries in POI, after failure of pelvic ultrasound examination to demarcate and assess the measures of both ovaries, and, second, to try correlate this ovarian morphology with other POI markers of the future prognosis of ovarian hormonal functions and fecundity.…”

Section: Introductionmentioning

confidence: 99%

Office Microlaparoscopy Using Augmented Local Anesthesia for Assessment of Primary Ovarian Insufficiency

Siam

2012

Journal of Gynecologic Surgery

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Objective: The objective of this study was to examine the usefulness of office microlaparoscopy with the patient under augmented local anesthesia in the assessment of types and future fertility prognosis of primary ovarian insufficiency (POI), after the failure to definitely visualize and measure both ovaries in women candidates included in the study. Methods: Forty-five patients with POI diagnosed in a private fertility care center between October 2006 and December 2010, who gave informed consent and underwent office microlaparoscopy under augmented local anesthesia, were studied. Pelvic ultrasound had failed to visualize and morphologically assess both ovaries in the women included. The cases were divided into four groups based on the microlaparoscopic ovarian morphology: group N (near to Normal), group G (gyrus shaped), group A (atrophied), and group S (streak shaped). These groups were analyzed with respect to patient background, blood hormone levels, and the level of antinuclear antibodies measured. Results: No significant differences in patient background and serum hormone levels were observed among groups. There was a complete absence of both ovaries in 5 patients included. There was a tendency toward increase in antinuclear antibody positive as the ovarian morphology approached normal, in contrast to both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) serum levels. Groups N and G showed some improvement, such as regular spontaneous menstruation, and forthcoming pregnancy, which happened in group N. Many other internal genital anomalies could be diagnosed during the same office micrlaparoscopic procedure. Conclusions: Office microlaparoscopy with the patient under local anesthesia is a useful procedure in the definite demarcation, and differentiation between the types POI, regarding menstrual regularity and future fertility prognosis. ( J GYNECOL SURG 28:338)

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“…Third, there is concern over whether the minute biopsy tissue is adequate to evaluate the presence or absence of follicles in the whole ovary. In fact, cases of patients achieving pregnancy, even though no follicles are found in the biopsy, have been reported 11,18 . Voigt et al 18 .…”

Section: Discussionmentioning

confidence: 99%