Pregnancy Following Uterine Artery Embolization with Polyvinyl Alcohol Particles for Patients with Uterine Fibroid or Adenomyosis

Kim, Man Deuk; Kim, Nahk Keun; Kim, Hee Jin; Lee, Mee Hwa

doi:10.1007/s00270-004-8236-3

Cited by 60 publications

(34 citation statements)

References 18 publications

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“…To date, only a few clinical studies, all using PVA as embolic agent, report successful deliveries after UAE (4,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Only Pron et al and the Ontario Uterine Fibroid Embolization collaborative group (9) have reported that of 35 women trying to conceive after embolization with 355-500 mm PVA, 21 women, of average age 34 years (range, 27-42 y), became pregnant.…”

Section: Fertilitymentioning

confidence: 93%

“…Cases of intrauterine growth retardation have indeed been reported after hypogastric artery ligation (19,74) or UAE (18,20). In his retrospective analysis of 50 published cases of pregnancy after UAE, Goldberg et al (7) found that women who become pregnant after UAE are at risk for conceiving newborns with smallness for gestational age (7%).…”

Section: Hypotrophymentioning

confidence: 96%

“…However, it is still controversial whether UAE is a safe procedure for women desiring future fertility (5,6), and most centers have advocated a cautious approach in dealing with these patients. Sparse clinical data argue in favor of using UAE for women trying to conceive because some women who have had fibroid embolization have become pregnant and have had successful deliveries (4,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Nevertheless, these reports of pregnancy after UAE remain anecdotal (case reports and limited clinical studies) and involve <100 pregnancies.…”

mentioning

confidence: 88%

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Fertility after bilateral uterine artery embolization in a sheep model

Laurent

Pelage

Wassef

et al. 2008

Fertility and Sterility

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Section: Fertilitymentioning

confidence: 93%

Section: Hypotrophymentioning

confidence: 96%

mentioning

confidence: 88%

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Fertility after bilateral uterine artery embolization in a sheep model

Laurent

Pelage

Wassef

et al. 2008

Fertility and Sterility

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“…To date, there have not been significant data about pregnancy outcomes after surgical occlusion or embolization of the uterine artery. A systematic search of the biomedicine database MEDLINE from 2000 to 2005, using terms such as fibroid, pregnancy, and uterine artery, identified only a limited number of clinical studies (2)(3)(4)(5)(6)(7)(8)(9)(10), with the exception of case reports. Only one pilot study of the available literature contains data prospectively comparing pregnancy results between uterine artery embolization (UAE) and laparoscopic uterine artery occlusion (LUAO) (11).…”

mentioning

confidence: 99%

Pregnancy outcomes after uterine artery occlusion: prospective multicentric study

Holub

Mára

Kužel

et al. 2008

Fertility and Sterility

111

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“…Few articles have focused on the effect of UAE for fibroids and its outcome on future fertility and pregnancy. To the best of our knowledge, pregnancy after UAE has been described in the literature in the form of case reports [17][18][19][20], a review article [21], and retrospective reports of case series [22][23][24][25][26][27][28][29]. As of March 2008, more than 170 patients worldwide had become pregnant after UAE.…”

mentioning

confidence: 99%

Pregnancy After Uterine Artery Embolization for Symptomatic Fibroids: A Series of 15 Pregnancies

Firouznia

Ghanaati

Sanaati³

et al. 2009

American Journal of Roentgenology

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[12,13], and cervical ectopic pregnancy [14][15][16] has been reported.The effects of embolization on ovarian function are important when preservation of fertility is desired. Few articles have focused on the effect of UAE for fibroids and its outcome on future fertility and pregnancy. To the best of our knowledge, pregnancy after UAE has been described in the literature in the form of case reports [17][18][19][20], a review article [21], and retrospective reports of case series [22][23][24][25][26][27][28][29]. As of March 2008, more than 170 patients worldwide had become pregnant after UAE. At a university-affiliated referral hospital in Iran, we evaluated the pregnancies of women who underwent UAE for symptomatic fibroids and desired to become pregnant. Subjects and Methods From Wo m e n's I m ag i ng • O r ig i n a l R e s e a rc h Uterine fibroids are among the most common benign tumors of the female pelvis that cause abnormal menstrual bleeding. Uterine artery embolization (UAE) in the management of uterine myomas was first reported by Ravina et al. in 1995 [1]. Their promising results were confirmed in several uncontrolled cohort studies, which showed an approximately 50% decrease in uterine volume and relief of symptoms in 80-90% of patients [2]. The advantages of UAE include lower cost and more rapid recovery than can be achieved with conventional therapies [3][4][5]. The efficacy of uterine embolization in the management of pelvic hemorrhage has been well documented in obstetrics and gynecology [6][7][8]. Successful pregnancy outcome after embolization for obstetric hemorrhage [9,10] Please see the commentary on this article, which appears on the following pages. W O M E N ' S I M A G I N G PROOF Copyrighted Material For Review Only • Not for DistributionPage Copy OBJECTIVE. The purpose of this study was to report on pregnancies and their outcome after uterine artery embolization for uterine fibroids. SUBJECTS AND METHODS. From 2001 to 2004, 102 patients (mean age, [± SD]35.7 ± 6.4 years; range, 20-48 years) with symptomatic uterine fibroids underwent uterine artery embolization with 500-to 710-µm polyvinyl alcohol particles. The mean uterine volume was 552 ± 649 cm 3 (range, 94-4,656 cm 3 ), and the dominant fibroid size was 228 ± 359 cm 3 (range, 14-2,618 cm 3 ) before the procedure. During the 2-year follow-up period, the patients were asked whether they were trying to achieve pregnancy and whether they were successful. We obtained pregnancy and obstetric records of the pregnant women from physicians' offices and hospitals.RESULTS. Among 102 women who underwent bilateral uterine artery embolization, 23 (22.5%) were seeking to become pregnant, and 14 of the 23 (61%) became pregnant, nine having been nulliparous. One patient had two pregnancies. Fourteen pregnancies were spontaneous, and one was achieved by zygote intrafallopian transfer. Two miscarriages occurred, one in the 12th and one in the 16th week of gestation. The other 13 pregnancies went to term, were uncomplicated, and ended in elective...

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Pregnancy Following Uterine Artery Embolization with Polyvinyl Alcohol Particles for Patients with Uterine Fibroid or Adenomyosis

Abstract: Although the absolute number of cases was small, UFE with PVA particles ultimately did not affect fertility in the women who underwent the procedure.

Cited by 60 publications

References 18 publications

Fertility after bilateral uterine artery embolization in a sheep model

Fertility after bilateral uterine artery embolization in a sheep model

Pregnancy outcomes after uterine artery occlusion: prospective multicentric study

Pregnancy After Uterine Artery Embolization for Symptomatic Fibroids: A Series of 15 Pregnancies

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