Pregnancy in a Rare Case of Intracranial Rosai Dorfman Disease (RDD)

Ksheerasagar, Shashikala; Venkatesh, N.; Raizada, N.; Prathima, K. M.; Kamble, Ravindra B; Srinivas, Kuppa; Jacklin, M. A. Suzi; Chandramouli, Bangalore A.

doi:10.1007/s13224-019-01254-y

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…For the complicated cases, systemic chemotherapy can be selected. But we need to take obvious and sever side effects into consideration, especially for pregnancy or young patients [22,28]. Penetration of the blood-brain barrier will affect the therapeutic effect, so we should consider this factor when we decide to choose which kind of chemotherapy agents [28].…”

Section: Discussionmentioning

confidence: 99%

Postoperative Management of The Primary Single Intracranial Rosai-Dorfman Disease: Case Report and Literature Review

Liu

et al. 2020

Preprint

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The isolated intracranial Rosai-Dorfman disease (RDD) is extremely rare. It remains unclear for the best management of the residual lesions. In this report, the authors describe a case of primary single intracranial RDD treated with Gamma knife radiosurgery after partial resection, review all the related literatures and summarize the postoperative management data, in order to provide useful therapeutic information.A 23-year-old male presented with a more than 10-month history of dizziness, blurred vision and weakness. Preoperative MR imaging revealed a giant lesion involving the left middle cranial fossa and extending to the left cavernous sinus. He underwent fronto-temporal craniotomy and eventually achieved partial resection of the lesion. Postoperative histopathological results suggested a diagnosis of intracranial RDD. The residual lesion was treated with Gamma knife radiosurgery about 1 month after surgery. The follow-up imaging showed an obvious decrease in the size of the residual lesion.We are the second to provide the detail parameters of gamma knife therapy, which may be a reference for clinical neurosurgeons. Compared with the firstly reported case, our patient with a longer follow-up time has different therapeutic dose. Based on our own experience and an updated literature review, adjuvant stereotactic radiosurgery may be a safe and effective treatment for primary single intracranial RDD patients with incomplete excision. Other adjuvant therapies can be as an option in refractory patients.

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Section: Discussionmentioning

confidence: 99%

Postoperative Management of The Primary Single Intracranial Rosai-Dorfman Disease: Case Report and Literature Review

Liu

et al. 2020

Preprint

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Cyclophosphamide/prednisolone/vinblastine

2020

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Pregnant patient with extranodal CNS Rosai-Dorfman disease with new-onset seizures: the conundrum of differentiating disease progression from eclampsia

et al. 2021

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A 31-year-old woman at 30 weeks gestation presented to the emergency department following multiple seizures. Her history was significant for extranodal Rosai-Dorfman Disease (RDD) with central nervous system (CNS) lesions. RDD, a rare form of non-Langerhans cell histiocytosis, commonly presents with non-tender cervical lymphadenopathy. CNS involvement accounts for a small number of cases in those with extranodal disease. Patients with CNS RDD can have a variety of neurological symptoms, including seizures. Eclampsia, a relatively rare obstetric hypertensive disorder, is always within the differential diagnosis for patients presenting with late gestation seizures. We present the challenging evaluation and treatment of a patient whose clinical picture did not clearly differentiate eclampsia from new onset seizures related to progression of her RDD. This conundrum perhaps resulted in unnecessary preterm operative delivery of a critically ill patient. Only follow-up of the patient helped clarify the likely antepartum diagnosis.

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Pregnancy in a Rare Case of Intracranial Rosai Dorfman Disease (RDD)

Cited by 3 publications

References 4 publications

Postoperative Management of The Primary Single Intracranial Rosai-Dorfman Disease: Case Report and Literature Review

Postoperative Management of The Primary Single Intracranial Rosai-Dorfman Disease: Case Report and Literature Review

Cyclophosphamide/prednisolone/vinblastine

Pregnant patient with extranodal CNS Rosai-Dorfman disease with new-onset seizures: the conundrum of differentiating disease progression from eclampsia

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