Pregnancy in a woman with congenital F-VII deficiency: a brief review of recent literature and case report

Hajjar, Rima; Hatoum, Inaam; Krounbi, Amina; Chahine, Rabih; Jalloul, Rahif; Ramadan, Mohamad

doi:10.1016/j.htct.2021.07.003

Cited by 3 publications

(2 citation statements)

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“…Furthermore, the patients' FVII activity, clinical manifestations, and bleeding history should be carefully considered before deciding on rFVIIa prophylaxis, a preferred agent. 4,8 In our case report, our patients both had severe FVIID (FVII < 5%) throughout their pregnancy but did not report any history of bleeding abnormal bleeding. We administered prophylaxis with a 25-μg/kg dose of rFVIIa before cesarean section and gave two more single doses postoperatively.…”

Section: Discussionmentioning

confidence: 62%

“…Based on previous case reports and analyses, it has been suggested that patients with severe FVIID (FVII <10%) may require prophylactic treatment. Furthermore, the patients’ FVII activity, clinical manifestations, and bleeding history should be carefully considered before deciding on rFVIIa prophylaxis, a preferred agent 4,8 . In our case report, our patients both had severe FVIID (FVII < 5%) throughout their pregnancy but did not report any history of bleeding abnormal bleeding.…”

Section: Discussionmentioning

confidence: 75%

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Pregnant Women with Severe Factor VII Deficiency Undergoing Cesarean Section Managed with a Short-Term Regimen of Recombinant Factor VIIa

et al. 2023

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 75%

Pregnant Women with Severe Factor VII Deficiency Undergoing Cesarean Section Managed with a Short-Term Regimen of Recombinant Factor VIIa

et al. 2023

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Viscoelastic testing guided coagulation management in factor VII deficiency for spinal anaesthesia and caesarean section

Yoon,

Haley,

Huffnagle

et al. 2024

BMJ Case Rep

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The risks and benefits of spinal anaesthesia must be assessed in patients with coagulation disorders. A woman in her 20s with congenital factor VII (FVII) deficiency (31%) was admitted at 38 weeks for caesarean delivery. A rotational thromboelastometry (ROTEM) analysis showed normal coagulation and spinal anaesthesia was performed safely. A repeated ROTEM analysis after haemostasis and uterine closure showed normal coagulation without fibrinolysis. No prophylactic FVII was administered, resulting in a cost savings of US$12 884. FVII level did not predict bleeding or fibrinolysis and FVII and tranexamic acid were not indicated.

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Feto-Maternal Outcomes in Pregnancy With Factor VII Deficiency in a Tertiary Care Institution

Sachdeva,

Kaur,

Aggarwal

et al. 2024

Cureus

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This paper aims to study antepartum and postpartum bleeding manifestations of patients with factor VII (FVII) deficiency, their management, and feto-maternal outcomes, to establish danger signs and management protocols. We describe a case series of nine pregnancies in four patients with FVII deficiency diagnosed at a tertiary care referral center in India between 2012 and 2023. Out of nine pregnancies, six had cesarean deliveries, two had vaginal deliveries, and one had dilatation and curettage for unwanted pregnancies. One out of nine pregnancies (11.11%) with an unknown FVII deficiency had antepartum hemorrhage (abruption) necessitating multiple transfusions, ICU stay, and neonatal loss. Three patients with no prior history of obstetric hemorrhage were diagnosed with severe deficiencies and received prophylactic recombinant FVII preoperatively, averting the potential loss of lives. In patients with no history of bleeding, no hemorrhage was reported with or without prophylaxis while 33.33% of hemorrhage was reported in patients with a history of bleeding. Factors like the history of bleeding, FVII levels, mode of delivery, and other risk factors for hemorrhage should all be considered to predict the risk of bleeding in delivery. Cesarean is a surgical procedure, and prophylactic use of recombinant FVII concentrate (rFVIIa) should be considered.

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Pregnancy in a woman with congenital F-VII deficiency: a brief review of recent literature and case report

Cited by 3 publications

References 22 publications

Pregnant Women with Severe Factor VII Deficiency Undergoing Cesarean Section Managed with a Short-Term Regimen of Recombinant Factor VIIa

Pregnant Women with Severe Factor VII Deficiency Undergoing Cesarean Section Managed with a Short-Term Regimen of Recombinant Factor VIIa

Viscoelastic testing guided coagulation management in factor VII deficiency for spinal anaesthesia and caesarean section

Feto-Maternal Outcomes in Pregnancy With Factor VII Deficiency in a Tertiary Care Institution

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