Pregnancy in a woman with Wilson's disease treated with zinc: A case report

Bhattacharyya, Sanjoy Kumar; Saha, Shyama Prasad; Samanta, Jaydeep; Roychowdhuri, Atanu

doi:10.5468/kjog.2012.55.3.180

Cited by 1 publication

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It may be hypothesized that this may be due to underlying disease or is related to anticopper therapy used during pregnancy. 21 There was no preeclampsia in our study.…”

Section: Discussionmentioning

confidence: 44%

“…These major findings of our study are compared with Ayesha Malik et al study 1 and Walshe et al study, 3 presented in Table 1. Fetal growth restriction was noted in a study by Bhattacharyya et al 21 The sudden omission of chelating agents in the antenatal period by the mother may be from apprehension of fetal affection or due to severe gastric irritation. Failure to comply with therapy has led to the significant progression of liver disease and liver failure in 1 to 12 months following discontinuation of treatment, resulting in death or necessitating liver transplantation.…”

Section: Discussionmentioning

confidence: 95%

“…Preexisting poor hepatic and renal profile or severe neuropsychiatric illness must be taken into consideration as even a well-chelated pregnancy can turn complicated. 21…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal and Perinatal Outcome of Wilson Disease in Pregnancy: A 5-year Experience at a Tertiary Care Center

Vishnupriya¹,

Sheela²,

Thayumanasundaram³

2017

Journal of South Asian Federation of Obstetrics and Gynaecology

View full text Add to dashboard Cite

Introduction Wilson disease is a very rare inherited autosomal recessive disorder, with an incidence of 1 in 30,000 live births, associated with impaired copper metabolism leading to decreased biliary excretion and accumulation of copper in the liver and brain. Patients may be asymptomatic or might present with fulminant liver disease or neuropsychiatric illness. Untreated Wilson disease is related to infertility/subfertility/recurrent pregnancy loss. Aim To study the maternal and perinatal outcomes of Wilson disease in pregnancy. Materials and methods It is a retrospective observational study carried out in the Department of Obstetrics and Gynecology, St. John's Medical College Hospital, Bengaluru, India, between November 2010 and November 2015. Five patients with Wilson disease were identified during the study period. Pregnancy outcome was good in all these five women who were on regular treatment. Conclusion Patients with Wilson disease who receive regular treatment and who remain asymptomatic and conceive normally have favorable pregnancy outcomes. They merit regular surveillance and active management in higher centers with multidisciplinary approach involving gastroenterologists, obstetricians, neurologists, and intensivists. How to cite this article Vishnupriya KMN, Sheela CNR, Thayumanasundaram M. Maternal and Perinatal Outcome of Wilson Disease in Pregnancy: A 5-year Experience at a Tertiary Care Center. J South Asian Feder Obst Gynae 2017;9(4):318-322.

show abstract

“…It may be hypothesized that this may be due to underlying disease or is related to anticopper therapy used during pregnancy. 21 There was no preeclampsia in our study.…”

Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 95%