Pregnancy in<i>β</i>-thalassemia trait carriers: an uneventful journey

Tsatalas, Constantinos; Chalkia, Panagiota; Pantelidou, Despoina; Margaritis, Dimitrios; Bourikas, Georgios; Spanoudakis, Emmanouil

doi:10.1179/102453309x439791

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…Other major medical complications were not observed. This is supported by a study by Tsatsalas, who has described the pregnancies with beta-thalassemia carriers as 'an uneventful journey' [12]. Similar results have been described by Charoenboon et al [13].…”

Section: Discussionsupporting

confidence: 76%

Outcome of Pregnancy with Hemoglobinopathy in a Tertiary Care Center

Chauhan

Prasad

2017

J Obstet Gynecol India

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Section: Discussionsupporting

confidence: 76%

Outcome of Pregnancy with Hemoglobinopathy in a Tertiary Care Center

Chauhan

Prasad

2017

J Obstet Gynecol India

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“…Some studies have shown that thalassemia traits in pregnant women represent "an uneventful journey", whereas other have shown that the prevalence of adverse pregnancy outcomes, such as PIH or SGA, increase in pregnant women affected by thalassemia traits. (10,11,23) In our study, the thalassemia trait groups have a higher risk of PIH. With subgroup analysis, the incidence of PIH is higher in the β thal trait and HbE trait groups compared to the normal group.…”

Section: Discussionsupporting

confidence: 49%

Pregnancy Outcomes Among Women Affected With Thalassemia Traits

Ruangvutilert¹,

Phatihattakorn²,

Yaiyiam³

et al. 2022

Preprint

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ObjectiveTo compare the maternal and perinatal outcomes between a group of pregnant women diagnosed with thalassemia traits and normal controls.Study designA retrospective cohort study was conducted on singleton pregnant women affected and unaffected by thalassemia traits who attended an antenatal care clinic and delivered in Siriraj Hospital. Thalassemia status for all subjects was diagnosed by hemoglobin typing and/or DNA analysis. Patient charts were reviewed from January 2007 to December 2018. The control participants were randomly selected from the same period, with a control-case ratio of around 1:1.ResultsOverall, 1288 women with thalassemia traits (348 with α thal-1 trait, 424 with β thal trait and 516 with HbE trait) and 1305 women in the control group were recruited. Baseline characteristics of both groups were similar, with the exception that the hematocrit level in the first trimester in the thalassemia trait group was significantly lower than that in the control group (34.8±3.4% VS 36.9±3.0%; p < 0.001). The prevalence of pregnancy-induced hypertension (PIH) was higher in the thalassemia trait group, at 6.9% VS 4.7% in the control group; p = 0.018. When subgroups were analyzed between each thalassemia trait, the number of maternal anemias in the first and third trimester were higher for all thalassemia traits compared to the normal group. The β thal and HbE traits increased the risk of PIH, with a relative risk (RR) = 1.67 and 1.66, respectively. Additionally, the rate of neonates with a low Apgar score at 1 minute was significantly higher in the HbE trait; RR = 2.06.ConclusionsThalassemia traits minimally but significantly increase the risk of hypertensive disorders and low Apgar score in pregnancy. In addition, physiological changes during pregnancy may worsen the severity of anemia in the pregnant women with thalassemia traits.

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“…Therefore, their pregnancy will usually be uneventful and normally completed. 97 , 98 Thalassemia per se in combination with gestational anemia (secondary to increased fluid compartment of the body) account partly for different complications of the thalassemic pregnancy, such as fetal intrauterine growth restriction (IUGR) and preterm labor. 99 , 100 Most centers transfuse pregnant women aiming to maintain hemoglobin at the preconception goal (>10 g/dL) to ensure appropriate fetal growth.…”

Section: Antepartum Managementmentioning

confidence: 99%

Pregnancy in women with thalassemia: challenges and solutions

Petrakos

Andriopoulos

Tsironi

2016

IJWH

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Advances in treatment of thalassemia have led to the aging of thalassemic patients, and consequently concern about successful reproductive outcome is augmented. Although women with thalassemia intermedia only were considered competent of achieving pregnancy, case series reveal the willingness of both thalassemia major and thalassemia intermedia women to have a family. Pregnancy in general is characterized by dynamic multiple-system changes and increased susceptibility to oxidative stress, while homozygous, transfusion-dependent, β-thalassemia patients manifest cardiac, hepatic, endocrine, and metabolic disorders attributable to chronic anoxia and iron overload and thalassemia intermedia, usually nontransfused, is associated with augmented risk of thromboembolic events. Pregnancy in thalassemia should be considered a high risk for both mother and fetus, and favorable outcomes are the result of continuous preconception, antenatal, and postpartum assessment and management by a team of thalassemia experts.

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Pregnancy inβ-thalassemia trait carriers: an uneventful journey

Cited by 17 publications

References 22 publications

Outcome of Pregnancy with Hemoglobinopathy in a Tertiary Care Center

Outcome of Pregnancy with Hemoglobinopathy in a Tertiary Care Center

Pregnancy Outcomes Among Women Affected With Thalassemia Traits

Pregnancy in women with thalassemia: challenges and solutions

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