Pregnancy in two patients of Glanzmann's thrombasthenia: a rare case report

Singh, Sujata; Swain, Santosh Kumar; Das, Leena; Jena, Rabindra Kumar; Das, Om Avishek; Sahoo, Balaram; Subudhi, Soubhagya Ranjan; Deepti, Kapila Suguna

doi:10.18203/2320-1770.ijrcog20151634

Cited by 1 publication

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To the pregnant females, the risks of abortions, antepartum and postpartum haemorrhages are all increased. 15,16 The foetal risk is related to alloimmune thrombocytopenia (induced by transplacental passage of the maternal IgG anti-GP IIb/IIIa isoantibodies) and potential intracranial haemorrhage. 15,16 In such cases, multidisciplinary care becomes paramount for ensuring optimal maternal and fetal outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 The foetal risk is related to alloimmune thrombocytopenia (induced by transplacental passage of the maternal IgG anti-GP IIb/IIIa isoantibodies) and potential intracranial haemorrhage. 15,16 In such cases, multidisciplinary care becomes paramount for ensuring optimal maternal and fetal outcomes. 16 The screening tests PT, aPTT levels, and platelet counts and morphology are normal in individuals with GT.1…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Glanzmann’s thrombasthenia: a rare bleeding disorder in a Nigerian girl

et al. 2020

View full text Add to dashboard Cite

Introduction: Glanzmann’s Thrombasthenia (GT) is a rare autosomal recessive bleeding disorder due to defective platelet membrane glycoprotein GP IIb/IIIa (integrin αIIbβ3). The prevalence is estimated at 1:1,000,000 and it is commonly seen in areas where consanguinity is high. Case Presentation: The authors report a 12 year old Nigerian girl of Igbo ethnic group, born of non-consanguineous parents, who presented with prolonged heavy menstrual bleeding which started at menarche 3 months earlier, weakness and dizziness. She had a past history of recurrent episodes of prolonged epistaxis, gastrointestinal bleeding and gum bleeding during early childhood. On examination, she was severely pale with a haemic murmur and vaginal bleeding. The initial diag- nosis was menorrhagia secondary to bleeding diathesis possibly von Willebrand’s Disease. She was on supportive treatment with fresh whole blood, fresh frozen plasma and platelets until diagnosis of GT was made in the USA. Currently, she is on 3 monthly intramuscular Depo-provera with remarkable improvement. Conclusion: To the best of our knowledge, this is the first documented report of GT in our environment where consan- guinity is rarely practised. Our health facilities require adequate diagnostic and treatment facilities for rare diseases like GT. Keywords: Glanzmann’s thrombasthenia; Menorrhagia; Nigerian girl.

show abstract