Pregnancy induced hypertension in women with gestational carbohydrate intolerance: the diagest study

Vambergue, A.; Nuttens, M C; Goeusse, P; Biausque, Serge; Lepeut, M.; Fontaine, P.

doi:10.1016/s0301-2115(01)00556-5

Cited by 72 publications

(46 citation statements)

References 20 publications

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“…The pathophysiologies of both illnesses have been shown to be associated with each other [3,4,5,6]. It appears that gestational diabetes and pre-eclampsia have several mechanisms in common: altered carbohydrate metabolism causes vascular changes such as arteriosclerosis and a glomerular filtration dysfunction, which results in a predisposition to pre-eclampsia.…”

Section: Introductionmentioning

confidence: 99%

“…It appears that gestational diabetes and pre-eclampsia have several mechanisms in common: altered carbohydrate metabolism causes vascular changes such as arteriosclerosis and a glomerular filtration dysfunction, which results in a predisposition to pre-eclampsia. Some authors have recently discussed gestational diabetes as a risk factor of pre-eclampsia and pre-eclampsia as a possible consequence of gestational diabetes [5]. This theory is supported by a prospective random study that the treatment of gestational diabetes mellitus reduced the rate of pre-eclampsia by 30% [7].…”

Section: Introductionmentioning

confidence: 99%

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Distinct DNA Methylomes of Human Placentas Between Pre-Eclampsia and Gestational Diabetes Mellitus

Liu

Zhang

Rong

et al. 2014

Cell Physiol Biochem

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Background: The placenta acts not only as a conduit of nutrient and waste exchange between mother and developing fetus but also functions as a regulator of the intrauterine environment. Pre-eclampsia (PE) and gestational diabetes mellitus (GDM) are leading causes of complications during pregnancy. Pathophysiologies show that they are associated with one another. Epigenetics provides a link between environmental factors that have previously been linked to poor pregnancy outcomes and fetal programming. Methods and Results: The present study investigated genome-wide DNA methylation changes in PE and GDM compared with control subjects through DNA methylation microarray. We found that the methylation patterns of placentas from PE and GDM women were similar; 64.4% of the annotated genes with differential methylation presented concordant changes between PE and GDM patients. Significantly, the same functional processes were affected by PE and GDM, with cell adhesion and cell differentiation being the most populated clusters and including genes related to carbohydrate metabolism and lipid metabolism. Conclusion: Our work showed that of DNA methylation patterns in human placentas are reliably and significantly associated with PE and GDM. DNA methylation status in the human placenta can function as a marker for the intrauterine environment and potentially play a functional role in PE and GDM development.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distinct DNA Methylomes of Human Placentas Between Pre-Eclampsia and Gestational Diabetes Mellitus

Liu

Zhang

Rong

et al. 2014

Cell Physiol Biochem

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“…Gestational glucose intolerance affects 1 to 16% of pregnancies and is associated with increased risk of gestational and perinatal adverse outcomes such as macrosomia, respiratory distress syndrome, fetal hyperinsulinemia and, in some settings, perinatal death (3). Pre-eclampsia has been frequently reported as a complication of gestational diabetes (4) but the relationship between these two conditions is not well understood. Several studies suggest underlying common pathophysiology, including insulin resistance, chronic inflammation and endothelial dysfunction (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Gestational diabetes and pre-eclampsia: common antecedents?

Wendland

Duncan

Belizán

et al. 2008

Arq Bras Endocrinol Metab

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Objetivo: Avaliar a concordância do padrão de fatores de risco de mulheres que desenvolvem diabetes gestacional e pré-eclâmpsia. Métodos: Estudo de coorte prospectivo em clínicas de atendimento pré-natal do Sistema Único de Saúde de seis capitais do Brasil, 4.766 mulheres grávidas de 20 a 48 anos de idade foram arroladas de maneira consecutiva entre a 20º e 28º semanas de gestação. O hábito de fumar e os fatores de risco tradicionais para pré-eclâmp-sia e diabetes gestacional foram obtidos por entrevista no arrolamento. diabetes gestacional foi diagnosticada usando um teste oral de tolerância a glicose com 75 g e pré-eclâmpsia por meio de revisão de prontuário. Resultados: diabetes gestacional e pré-eclâmpsia são associadas com idade (rc 2,07; 95% Ic 1,65-2,23 e rc 1,55; 95% Ic 1,08-2,23, respectivamente), índice de massa corporal pré-gestacional (rc 1,62; 95% Ic 1,40-3,53 e rc 1,83; 95% Ic 1,52-4,80, respectivamente) e ganho de peso precocemente durante a gestação (rc 1,28; 95% Ic 1,12-1,47 e rc 1,27; 95% Ic 1,06-1,52, respectivamente).

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“…Another study have been found in French including 15 maternity units to found an association GDM and almost all forms of PIH (OR=2.86, 95% CI: 1.05, 7.83) (Vambergue et al, 2002). A number of other studies have been examined to understand the association between GDM and PIH.…”

Section: Study Designs For Relation Between Pih and Gdmmentioning

confidence: 99%

Relationship between gestational diabetes and pregnancy induced hypertension (PIH)

Perveen¹,

Jabeen²,

Iqbal³

2015

Int Curr Pharm J

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Pregnancy-induced hypertension (PIH) and gestational diabetes mellitus (GDM) both have no adequate classification in addition to nomenclature that creates difficulties for researchers to find link between them. Aim of this work was to review the most recent data available on PIH and GDM and find the association between both conditions during gestation. Epidemeologies and whole studies which have done till now days, could not satisfy that what is association between PIH and GDM. The main issue to solve is how to find the association between GDM and PIH. Very limited data and research studies are available, creating hindrance to find any association. The one way to find the association now, can be that it should be checked the level of hypertension before, during and after gestation. According to the available data and research, it could be deduced that insulin resistance, present in non-insulin dependent diabetes mellitus (NIDDM), may provide association more frequently. However, no direct evidential data is available for this link.Perveen et al., International Current Pharmaceutical Journal, October 2015, 4(11): 453-456

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Pregnancy induced hypertension in women with gestational carbohydrate intolerance: the diagest study

Cited by 72 publications

References 20 publications

Distinct DNA Methylomes of Human Placentas Between Pre-Eclampsia and Gestational Diabetes Mellitus

Distinct DNA Methylomes of Human Placentas Between Pre-Eclampsia and Gestational Diabetes Mellitus

Gestational diabetes and pre-eclampsia: common antecedents?

Relationship between gestational diabetes and pregnancy induced hypertension (PIH)

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