Pregnancy management complicated by intrauterine growth restriction

Ganichkina, Ganichkina M.B.; Mantrova, Mantrova D.A.; Kan, Kan N.Е.; Tyutyunnik, Tyutyunnik V.L.; Khachaturyan, Khachaturyan A.A.; Зиганшина, М. М.

doi:10.18565/aig.2017.10.5-11

Cited by 5 publications

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“…Задержка роста плода (ЗРП) -актуальная проблема современного акушерства и перинатологии. Частота данного осложнения составляет от 5% до 23% [1,2]. Проблема ЗРП вносит значительный вклад в структуру перинатальной заболеваемости и смертности [3,4].…”

Section:  введениеunclassified

Molecular Predictors of Fetus Growth Delay

Ганчар

2023

Репродуктивное Здоровье. Восточная Европа

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Цель. На основании изучения метаболического профиля свободных аминокислот у женщин в 1-м триместре беременности создать метод прогнозирования задержки роста плода. Материалы и методы. На 1-м этапе произведен забор плазмы крови у 518 женщин в сроке беременности 11–13 недель. Плазма криоконсервирована в условиях умеренно низкой температуры (–80 °С). Произведен анализ исходов беременности и родов. На 2-м этапе в исследование включено 50 пациенток: 1-я группа (основная) – 29 пациенток с подтвержденным диагнозом задержки роста плода; 2-я группа (контрольная) – 21 женщина с беременностью без осложнений. В плазме крови методом высокоэффективной жидкостной хроматографии определено содержание 40 свободных аминокислот, их производных и метаболитов. Результаты. Методом логистической регрессии получена формула, включающая определение концентрации таурина и аспарагина в плазме крови женщин в 1-м триместре беременности, при расчете индекса p>0,55 прогнозируют задержку роста плода, а при p<0,55 делают заключение о низком риске развития данного осложнения. Заключение. Предложен метод прогнозирования задержки роста плода с чувствительностью 93%, специфичностью 90%. Purpose. Based on the study of the metabolic profile of free amino acids in women in the 1st trimester of pregnancy, create a method for predicting fetal growth retardation. Materials and methods. At the 1st stage, blood plasma was taken from 518 women at 11–13 weeks of gestation. The plasma is cryopreserved at moderately low temperatures (–80 °C). An analysis of the outcomes of pregnancy and childbirth was made. At stage 2, 50 patients were included in the study: group 1 (main) – 29 patients with a confirmed diagnosis of fetal growth retardation; group 2 (control) – 21 women with pregnancy without complications. In blood plasma, the content of 40 free amino acids, their derivatives and metabolites were determined by high-performance liquid chromatography. Results. Using the method of logistic regression, a formula was obtained, including the determination of the concentration of taurine and asparagine in blood plasma in the 1st trimester of pregnancy, when calculating the prognostic index p>0.55, fetal growth retardation is predicted, and at p<0.55, a conclusion is made about the low risk of developing this complication. Conclusion. A method for predicting fetal growth retardation with a sensitivity of 93% and a specificity of 90% has been proposed.

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Section:  введениеunclassified

Molecular Predictors of Fetus Growth Delay

Ганчар

2023

Репродуктивное Здоровье. Восточная Европа

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“…Частота ЗРП в развитых странах составляет от 5% до 10% [1][2][3], в развивающихся странах достигает 20-23% [4]. В России ЗРП осложняет 5-18% беременностей [5,6].…”

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Prediction of perinatal outcomes in pregnant women with fetal growth retardation

Долгушина

Vereina

Фартунина

et al. 2021

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Introduction. An important problem of modern obstetrics is the development and improvement of methods for predicting fetal growth retardation (FGR) and pregnancy outcomes in this pathology, since there are no proven effective treatments for FGR. Purpose of the study — to develop prediction criteria for newborn hypotrophy and cumulative adverse perinatal outcome in pregnant women with FGR. Objective. To identify key predictive factors for adverse perinatal outcomes in pregnancy complicated by FGR. Material and methods. A case-control, cohort-based study was conducted that included 155 pregnant women with FGR, who were divided into two groups after delivery: Group 1 included 90 patients with neonatal hypotrophy and Group 2 included 65 patients without neonatal hypotrophy. A comprehensive analysis of clinical and anamnestic, laboratory and instrumental data, peculiarities of the course of pregnancy and perinatal outcomes was performed. FGR was determined on the basis of ultrasound fetometry. Results. Factors associated with neonatal hypotrophy and unfavorable perinatal outcome were: impaired blood flow in the uterine arteries and/or umbilical artery, early preeclampsia and scarcity of water. Protective factors were antibacterial therapy for intrauterine infection, administration of low-molecular-weight heparin in the first trimester, and acetylsalicylic acid starting from the 12th to 16th weeks of gestation. Conclusion. The most promising measures in the prevention of FGR and adverse perinatal outcomes in this pathology may be timely prescription of antithrombotic correction and treatment of genital infections.

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Influence of Collagen Production, Collagenase Activity and Amino Acids Level on Formation of Fetal Growth Restriction in Women with Placental Insufficiency

et al. 2022

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Rationale. According to WHO, about 21 million children are born annually in the world with low body weight. Currently, the problems of etiology, diagnosis and treatment of fetal growth retardation (FGR) are very relevant for obstetrics and perinatology. Purpose to study the level of collagen (COL1) collagenase activity (MMP1), and content of proline, ornithine in the maternal blood serum, amniotic fluid, placenta and cord blood of patients with placental insufficiency, and to identify their role in the formation of fetal growth restriction (FGR) during early pregnancy. Methods. 150 women were examined, which made up 2 groups control (with uncomplicated pregnancy, n = 105) and main (with IUGR, n = 45). All measurements were performed in maternal blood serum, amniotic fluid, placenta and cord blood of women of both groups. Collagen content and collagenase activity are determined by ELISA kits, USA. Determination of amino acids (proline, ornithine) was carried out by capillary electrophoresis on the device Capel-105 (St. Petersburg). Results. As a result of the correlation analysis in the study of all biofluids by the Spearman method with the calculation of the rank correlation coefficient (r) in the group of women with FGR, significant correlations between collagen production and collagenase activity were revealed. The most pronounced interdependence (r = 0.85; p 0.05) was found in the maternal blood serum. Conclusions. A relationship was found between the studied parameters (collagen, collagenase, proline, ornithine) in blood serum, amniotic fluid, cord blood and placenta of women with placental insufficiency and their role in the formation of fetal growth retardation was established.

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Pregnancy management complicated by intrauterine growth restriction

Cited by 5 publications

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Molecular Predictors of Fetus Growth Delay

Molecular Predictors of Fetus Growth Delay

Prediction of perinatal outcomes in pregnant women with fetal growth retardation

Influence of Collagen Production, Collagenase Activity and Amino Acids Level on Formation of Fetal Growth Restriction in Women with Placental Insufficiency

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